Problem Formulations for the Risk Evaluations To Be Conducted Under the Toxic Substances Control Act, and General Guiding Principles To Apply Systematic Review in TSCA Risk Evaluations; Notice of Availability

EPA is publishing and taking comments on the problem formulation documents for the first 10 chemical substances undergoing risk evaluation under the Toxic Substances Control Act (TSCA). Comments received will inform the development of draft risk evaluation documents for these 10 chemical substances. The 10 problem formulation documents announced in this document refine the scope documents published in June 2017 and are an additional interim step, prior to publication of the draft risk evaluations. EPA is also publishing and taking comments on a document entitled: ``Application of Systematic Review in TSCA Risk Evaluations,'' which sets out general principles to guide EPA's application of systematic review for TSCA risk evaluations. The Office of Pollution Prevention and Toxics (OPPT) generally intends to apply systematic review principles in the development of risk evaluations under TSCA. The systematic review document includes a structured process of identifying, evaluating and integrating evidence for both the hazard and exposure assessments developed during the TSCA risk evaluation process. This document may be revised periodically. EPA welcomes public input on the document.