80 FR 15791 - Agency Forms Undergoing Paperwork Reduction Act Review
DEPARTMENT OF HEALTH AND HUMAN SERVICES
Centers for Disease Control and Prevention Federal Register Volume 80, Issue 57 (March 25, 2015)
Centers for Disease Control and Prevention
Federal Register Volume 80, Issue 57 (March 25, 2015)
| Page Range | 15791-15792 | |
| FR Document | 2015-06801 |
[Federal Register Volume 80, Number 57 (Wednesday, March 25, 2015)] [Notices] [Pages 15791-15792] From the Federal Register Online [www.thefederalregister.org] [FR Doc No: 2015-06801] ----------------------------------------------------------------------- DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention [30Day-15-15IG] Agency Forms Undergoing Paperwork Reduction Act Review The Centers for Disease Control and Prevention (CDC) publishes a list of information collection requests under review by the Office of Management and Budget (OMB) in compliance with the Paperwork Reduction Act (44 U.S.C. Chapter 35). To request a copy of these requests, call (404) 639-7570 or send an email to omb@cdc.gov. Send written comments to CDC Desk Officer, Office of Management and Budget, Washington, DC or by fax to (202) 395-5806. Written comments should be received within 30 days of this notice. Proposed Project Public Health Associate Program (PHAP) Alumni Assessment--New -- Office for State, Tribal, Local, and Territorial Support (OSTLTS), Centers for Disease Control and Prevention (CDC). Background and Brief Description The Centers for Disease Control and Prevention (CDC) works to protect America from health, safety and security threats, both foreign and in the U.S. CDC strives to fulfill this mission, in part, through a competent and capable public health workforce. One mechanism to developing the public health workforce is through training programs like the Public Health Associate Program (PHAP). The mission of the Public Health Associate Program (PHAP) is to train and provide experiential learning to early career professionals who contribute to the public health workforce. PHAP targets recent graduates with bachelors or masters degrees who are beginning a career in public health. Each year, a new cohort of up to 200 associates is enrolled in the program. Associates are CDC employees who complete two-year assignments in a host site (i.e., a state, tribal, local, or [[Page 15792]] territorial health department or non-profit organization). Host sites design their associates' assignments to meet their agency's unique needs while also providing on-the-job experience that prepare associates for future careers in public health. Associates also receive CDC-based training in core public health concepts and topics to provide the knowledge, skills, and abilities necessary to succeed in their assignments and provide a foundation for a career in public health. PHAP hosts an initial in-person orientation and annual public health training at CDC and offers long-distance learning opportunities throughout the program. It is the goal of PHAP to have alumni seek employment within the public health system (i.e., federal, state, tribal, local, or territorial health agencies, or non-governmental organizations), focusing on public health or health/healthcare. When PHAP originated in 2007, the program focused on increasing recruitment and enrollment; to date, there has been limited systematic assessment of the program. As a result, one current program priority is focused on documenting program outcomes to inform refinements to program processes and activities, demonstrate program impact, and inform decision making about future program direction. The purpose of this information collection request is to gain approval to follow alumni career movement and progression following participation in PHAP. The information collection will enable the program to demonstrate evidence of program outcomes, specifically to document how many alumni are retained as members of the public health workforce, where alumni are employed, what topical and functional public health areas alumni support (e.g., chronic disease, infectious disease, assessment, communications, etc.), to what extent alumni support the capabilities of public health agencies at the federal, state, territorial, local, tribal, and non-governmental organizational levels, and to what extent PHAP has influenced alumni career paths (if at all). Information will be used to answer key program assessment questions, specifically: ``Is PHAP a quality program?'', ``Is PHAP an effective program?'', and ``What is the impact of PHAP?'' CDC will administer the PHAP Alumni Assessment at two different time points (1 year post-graduation, and 3 years post-graduation) to PHAP alumni. Assessment questions will remain consistent at each administration (i.e., 1 year, or 3 years post-PHAP graduation). The language, however, will be updated for each assessment administration to reflect the appropriate time period. It is estimated that there will be no more than 480 respondents (160 respondents annually) over the course of the three year approval period. The estimated time for data collection is 8 minutes per assessment administration. Assessments will be administered electronically; a link to the assessment Web site will be provided in the email invitation. The total annualized estimated burden is 21 hours. There are no costs to respondents except their time. Estimated Annualized Burden Hours ---------------------------------------------------------------------------------------------------------------- Number of Average burden Type of respondent Form name Number of responses per per response respondents respondent (in hours) ---------------------------------------------------------------------------------------------------------------- PHAP Alumni......................... PHAP Alumni Assessment. 160 1 8/60 ---------------------------------------------------------------------------------------------------------------- Leroy A. Richardson, Chief, Information Collection Review Office, Office of Scientific Integrity, Office of the Associate Director for Science, Office of the Director, Centers for Disease Control and Prevention. [FR Doc. 2015-06801 Filed 3-24-15; 8:45 am] BILLING CODE 4163-18-P
![Federal Register / Vol. 80, No. 57 / Wednesday, March 25, 2015 / Notices 15791
CXCR4 in HSCs is described. HSC are Siwicki, Harry L. Malech, and Joy Liu contact John D. Hewes, Ph.D. at hewesj@
the only cells in the bone marrow that (all of NIAID). mail.nih.gov.
are both pluripotent and long lived. Publication: McDermott DH, et al. Dated: March 20, 2015.
Bone marrow transplantation (BMT) Chromothriptic cure of WHIM Richard U. Rodriguez,
using HSC is an increasingly common syndrome. Cell. 2015 Feb
Acting Director, Office of Technology
medical therapy for severe hematologic 12;160(4):686–99. [PMID 25662009]. Transfer, National Institutes of Health.
cancers and primary hematologic Intellectual Property: HHS Reference
[FR Doc. 2015–06845 Filed 3–24–15; 8:45 am]
immunodeficiencies. However, for No. E–173–2014/0—US Patent
BILLING CODE 4140–01–P
significant HSC engraftment to occur Application No. 62/026,138 filed July
there must usually be pre-transplant 18, 2014.
conditioning with either irradiation or Licensing Contact: Sury Vepa, Ph.D.,
DEPARTMENT OF HEALTH AND
chemotherapy or both. The technology J.D.; 301–435–5020; vepas@
HUMAN SERVICES
described herein shows that it is mail.nih.gov.
possible to replace HSC without the Development of GPR124 Wildtype and Centers for Disease Control and
need for pre-transplant conditioning Knockout Brain Endothelial Reporter Prevention
regimen. It is known that the chemokine Cells [30Day–15–15IG]
receptor CXCR4 plays a critical role in
HSC homing to the bone marrow and in Description of Technology: There is
currently no effective way to block beta- Agency Forms Undergoing Paperwork
HSC quiescence. The inventors have Reduction Act Review
identified a patient in which one copy catenin signaling specifically in brain
of CXCR4 had been deleted in a somatic endothelial cells. There is neither an The Centers for Disease Control and
mutation of an HSC and this cell had effective way to block beta-catenin Prevention (CDC) publishes a list of
clonally repopulated the bone marrow. signaling stimulated by a particular Wnt information collection requests under
This led to experiments in mice where family member such as WNT7. The review by the Office of Management and
the inventors clearly demonstrated in a reporter cells created by the NIH Budget (OMB) in compliance with the
bone marrow transplantation model, investigator from GPR124 knockout Paperwork Reduction Act (44 U.S.C.
that donor cells with a single copy of mice provide a unique and effective tool Chapter 35). To request a copy of these
the Cxcr4 gene repopulate recipient to screen for drugs that can specifically requests, call (404) 639–7570 or send an
mice much faster and last much longer interfere with the Wnt7/GPR124 email to omb@cdc.gov. Send written
than donor cells having two copies of signaling pathway. Such drugs have comments to CDC Desk Officer, Office of
the Cxcr4 gene. This technology which potential for widespread therapeutic Management and Budget, Washington,
shows that HSCs with one copy of the application in the treatment of DC or by fax to (202) 395–5806. Written
CXCR4 gene have a durable selective cerebrovascular diseases, the third comments should be received within 30
advantage in bone marrow repopulation leading cause of death in the United days of this notice.
can solve the problem frequently States, and a variety of
neurodegenerative disorders such as Proposed Project
encountered in gene therapy, i.e., the
short-lived nature of gene-corrected Alzheimer’s disease, Parkinson disease, Public Health Associate Program
cells, by utilizing recently discovered amyotrophic lateral sclerosis, multiple (PHAP) Alumni Assessment—New –-
gene editing methods that can be used sclerosis, and others. Office for State, Tribal, Local, and
to delete one copy of CXCR4 gene in Potential Commercial Applications: Territorial Support (OSTLTS), Centers
gene-corrected cells. Research tools for drug screening. for Disease Control and Prevention
Competitive Advantages: The reporter (CDC).
Potential Commercial Applications cells are ideal for screening for drugs
Background and Brief Description
• Improvement of engraftment in that specifically interfere with the
Wnt7/GPR124 signaling pathway as the The Centers for Disease Control and
gene therapy protocols and in HSC Prevention (CDC) works to protect
transplantation. cells have no inherent low level Gpr124
expression. America from health, safety and security
• Improved bone marrow threats, both foreign and in the U.S.
Development Stage: Prototype.
transplantation, enhancing the Inventor: Brad St. Croix (NCI). CDC strives to fulfill this mission, in
efficiency and durability of donor cell Publication: Posokhova E, et al. part, through a competent and capable
repopulation. GPR124 functions as a WNT7-specific public health workforce. One
Competitive Advantages coactivator of canonical beta-catenin mechanism to developing the public
signaling. Cell Rep. 2015 Jan 13;10 health workforce is through training
• This technology potentially (2):123–30. [PMID 25558062]. programs like the Public Health
facilitates HSC transplantation without Intellectual Property: HHS Reference Associate Program (PHAP).
the need of radiation or chemotherapy No. E–079–2015/0—Research Tool. The mission of the Public Health
conditioning. Patent protection is not being pursued Associate Program (PHAP) is to train
• This technology may uniquely for this technology. and provide experiential learning to
overcome a major hurdle limiting all Licensing Contact: Betty B. Tong, early career professionals who
gene therapy applications, namely the Ph.D.; 301–594–6565; tongb@ contribute to the public health
failure to correct the gene defect over a mail.nih.gov. workforce. PHAP targets recent
long time. Collaborative Research Opportunity: graduates with bachelors or masters
rljohnson on DSK3VPTVN1PROD with NOTICES
Development Stage The National Cancer Institute is seeking degrees who are beginning a career in
statements of capability or interest from public health. Each year, a new cohort
• Early-stage parties interested in collaborative of up to 200 associates is enrolled in the
• In vitro data available research to further develop, evaluate, or program.
• In vivo data available (animal) commercialize agents that antagonize or Associates are CDC employees who
Inventors: Jiliang Gao, Philip M. promote Gpr124 function. For complete two-year assignments in a host
Murphy, David H. McDermott, Marie collaboration opportunities, please site (i.e., a state, tribal, local, or
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![15792 Federal Register / Vol. 80, No. 57 / Wednesday, March 25, 2015 / Notices
territorial health department or non- one current program priority is focused specifically: ‘‘Is PHAP a quality
profit organization). Host sites design on documenting program outcomes to program?’’, ‘‘Is PHAP an effective
their associates’ assignments to meet inform refinements to program program?’’, and ‘‘What is the impact of
their agency’s unique needs while also processes and activities, demonstrate PHAP?’’
providing on-the-job experience that program impact, and inform decision
CDC will administer the PHAP
prepare associates for future careers in making about future program direction.
Alumni Assessment at two different
public health. Associates also receive The purpose of this information
CDC-based training in core public collection request is to gain approval to time points (1 year post-graduation, and
health concepts and topics to provide follow alumni career movement and 3 years post-graduation) to PHAP
the knowledge, skills, and abilities progression following participation in alumni. Assessment questions will
necessary to succeed in their PHAP. The information collection will remain consistent at each
assignments and provide a foundation enable the program to demonstrate administration (i.e., 1 year, or 3 years
for a career in public health. evidence of program outcomes, post-PHAP graduation). The language,
PHAP hosts an initial in-person specifically to document how many however, will be updated for each
orientation and annual public health alumni are retained as members of the assessment administration to reflect the
training at CDC and offers long-distance public health workforce, where alumni appropriate time period. It is estimated
learning opportunities throughout the are employed, what topical and that there will be no more than 480
program. It is the goal of PHAP to have functional public health areas alumni respondents (160 respondents annually)
alumni seek employment within the support (e.g., chronic disease, infectious over the course of the three year
public health system (i.e., federal, state, disease, assessment, communications, approval period. The estimated time for
tribal, local, or territorial health etc.), to what extent alumni support the data collection is 8 minutes per
agencies, or non-governmental capabilities of public health agencies at assessment administration. Assessments
organizations), focusing on public the federal, state, territorial, local, tribal, will be administered electronically; a
health or health/healthcare. and non-governmental organizational link to the assessment Web site will be
When PHAP originated in 2007, the levels, and to what extent PHAP has provided in the email invitation. The
program focused on increasing influenced alumni career paths (if at
recruitment and enrollment; to date, total annualized estimated burden is 21
all).
there has been limited systematic Information will be used to answer hours. There are no costs to respondents
assessment of the program. As a result, key program assessment questions, except their time.
ESTIMATED ANNUALIZED BURDEN HOURS
Average
Number of
Number of burden per
Type of respondent Form name responses per
respondents response
respondent (in hours)
PHAP Alumni .................................................. PHAP Alumni Assessment ............................. 160 1 8/60
Leroy A. Richardson, individuals associated with the grant Scientific Review, National Institutes of
Chief, Information Collection Review Office, applications, the disclosure of which Health, 6701 Rockledge Drive, Room 4170,
Office of Scientific Integrity, Office of the would constitute a clearly unwarranted MSC 7806, Bethesda, MD 20892, (301) 435–
Associate Director for Science, Office of the invasion of personal privacy. 1725, bowersj@csr.nih.gov.
Director, Centers for Disease Control and Name of Committee: Center for Scientific
Prevention. Name of Committee: Center for Scientific
Review Special Emphasis Panel; RFA RM13–
Review Special Emphasis Panel; RFA RM14–
[FR Doc. 2015–06801 Filed 3–24–15; 8:45 am]
003: Transformative Research Award. 007: New Innovator Award.
BILLING CODE 4163–18–P Date: April 21, 2015. Date: April 23–24, 2015.
Time: 8:00 a.m. to 5:00 p.m. Time: 8:00 a.m. to 12:00 p.m.
Agenda: To review and evaluate grant Agenda: To review and evaluate grant
DEPARTMENT OF HEALTH AND applications. applications.
HUMAN SERVICES Place: Hyatt Regency Bethesda, One Place: Residence Inn Bethesda, 7335
Bethesda Metro Center, 7400 Wisconsin Wisconsin Avenue, Bethesda, MD 20814.
National Institutes of Health Avenue, Bethesda, MD 20814. Contact Person: Rajiv Kumar, Ph.D., Chief,
Contact Person: John L Bowers, Ph.D., MOSS IRG, Center for Scientific Review,
Center For Scientific Review; Notice of Scientific Review Officer, Center for National Institutes of Health, 6701 Rockledge
Closed Meetings Scientific Review, National Institutes of Drive, Room 4216, MSC 7802, Bethesda, MD
Health, 6701 Rockledge Drive, Room 4170, 20892, 301–435–1212, kumarra@csr.nih.gov.
Pursuant to section 10(d) of the MSC 7806, Bethesda, MD 20892, (301) 435–
(Catalogue of Federal Domestic Assistance
Federal Advisory Committee Act, as 1725, bowersj@csr.nih.gov.
Program Nos. 93.306, Comparative Medicine;
amended (5 U.S.C. App.), notice is Name of Committee: Center for Scientific 93.333, Clinical Research, 93.306, 93.333,
hereby given of the following meetings. Review Special Emphasis Panel; RFA RM14– 93.337, 93.393–93.396, 93.837–93.844,
The meetings will be closed to the 003: Transformative Research Award. 93.846–93.878, 93.892, 93.893, National
public in accordance with the Date: April 21, 2015.
rljohnson on DSK3VPTVN1PROD with NOTICES
Institutes of Health, HHS)
provisions set forth in sections Time: 8:00 a.m. to 5:00 p.m.
Agenda: To review and evaluate grant Dated: March 20, 2015.
552b(c)(4) and 552b(c)(6), Title 5 U.S.C.,
applications. Anna Snouffer,
as amended. The grant applications and Place: Hyatt Regency Bethesda, One
the discussions could disclose Deputy Director, Office of Federal Advisory
Bethesda Metro Center, 7400 Wisconsin
confidential trade secrets or commercial Committee Policy.
Avenue, Bethesda, MD 20814.
property such as patentable material, Contact Person: John L Bowers, Ph.D., [FR Doc. 2015–06844 Filed 3–24–15; 8:45 am]
and personal information concerning Scientific Review Officer, Center for BILLING CODE 4140–01–P
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Document Created: 2018-02-21 09:49:09
Document Modified: 2018-02-21 09:49:09
| Category | Regulatory Information | |
| Collection | Federal Register | |
| sudoc Class | AE 2.7: GS 4.107: AE 2.106: | |
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| Section | Notices | |
| FR Citation | 80 FR 15791 |
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