80 FR 18638 - Findings of Research Misconduct
DEPARTMENT OF HEALTH AND HUMAN SERVICES
Office of the Secretary Federal Register Volume 80, Issue 66 (April 7, 2015)
Office of the Secretary
Federal Register Volume 80, Issue 66 (April 7, 2015)
| Page Range | 18638-18639 | |
| FR Document | 2015-07897 |
[Federal Register Volume 80, Number 66 (Tuesday, April 7, 2015)] [Notices] [Pages 18638-18639] From the Federal Register Online [www.thefederalregister.org] [FR Doc No: 2015-07897] ----------------------------------------------------------------------- DEPARTMENT OF HEALTH AND HUMAN SERVICES Office of the Secretary Findings of Research Misconduct AGENCY: Office of the Secretary, HHS. ACTION: Notice. ----------------------------------------------------------------------- SUMMARY: Notice is hereby given that the Office of Research Integrity (ORI) has taken final action in the following case: Ryousuke Fujita, Ph.D., Columbia University: Based on the report of an investigation conducted by Columbia University (CU) and additional analysis conducted by ORI in its oversight review, ORI found that Dr. Ryousuke Fujita, former Postdoctoral Scientist, Taub Institute for the Aging Brain, Departments of Pathology and Cell Biology and Neurology, CU Medical Center, engaged in research misconduct in research supported by National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH), grant R01 NS064433 and National Institute of Aging (NIA), NIH, grant R01 AG042317. ORI found that Respondent engaged in research misconduct by falsifying and fabricating data for specific protein expressions in human-induced neuronal (hiN) cells derived skin fibroblasts of Alzheimer's disease patients and unaffected individuals in seventy-four (74) panels included in figures in the following two (2) publications and one (1) unpublished manuscript:Cell 146:359-371, 2011 (hereafter referred to as ``Cell 2011''). Nature 500:45-53, 2013 (hereafter referred to as ``Nature 2013''). ``Human induced neuron models of APOE4-associated Alzheimer's disease display altered APP endocytosis and processing.'' Unpublished manuscript. ORI found that Respondent engaged in research misconduct by knowingly and intentionally fabricating and falsifying research in seventy-four (74) [[Page 18639]] panels included in figures in Cell 2011, Nature 2013, and the unpublished manuscript. Respondent inflated sample numbers and data, fabricated numbers for data sets, manipulated enzyme-linked immunosorbent assay (ELISA) analysis, mislabelled immunoflourescent confocal images, and manipulated and reused Western blot images. Specifically, the Respondent Fabricated numbers for the data presented as a bar graph in nine (9) panels in Figures S6#, S6H, and S6J in Cell 2011, Figures 3B and S12 in Nature 2013, and Figures 2F, 4B, 4D, and 4F in the unpublished manuscript Falsely inflated the sample size of quantitative data presented as bar graphs in fifty-three (53) panels in Figures 6B, 7I, and S6J in Cell 2011, Figures 3G, 3H, 4C, S10, S11b-h, S12d-f, S13a, S13c, S14b-c, S15b-i, and S16a-f in Nature 2013, and Figures 4b, 4d, 4f, 4i, 6c-d, S1n, S1o, S2a-b, and S4c-k in the unpublished manuscript Falsely manipulated ELISA analysis to achieve desired results presented as bar graphs in nine (9) figure-panels in Figure 6B in Cell 2011 and Figures 2D, 2E, 3G, 3H, and S10a-d in Nature 2013 Falsely inflated the numerical values of the data in Figure 7I in Cell 2011 by a factor of 10 to improve results and appear consistent with data presented in supplementary information published with the paper Falsely reversed the labeling of immunoflourescent confocal images in Figures 7M and 7N in Cell 2011 and Figure S13A in Nature 2013 to obtain the desired results Flipped and resized the Western blot image for APP panel from Figure 12b and falsely reused it to represent APP results under completely different experimental conditions in Figure 12c in Nature 2013 Dr. Fujita has entered into a Voluntary Exclusion Agreement (Agreement) and has voluntarily agreed for a period of three (3) years, beginning on March 18, 2015: (1) to exclude himself from any contracting or subcontracting with any agency of the United States Government and from eligibility for or involvement in nonprocurement programs of the United States Government referred to as ``covered transactions'' pursuant to HHS' Implementation (2 CFR part 376 et seq) of OMB Guidelines to Agencies on Governmentwide Debarment and Suspension, 2 CFR part 180 (collectively the ``Debarment Regulations''); and (2) to exclude himself voluntarily from serving in any advisory capacity to the U.S. Public Health Service (PHS) including, but not limited to, service on any PHS advisory committee, board, and/or peer review committee, or as a consultant. FOR FURTHER INFORMATION CONTACT: Acting Director, Office of Research Integrity, 1101 Wootton Parkway, Suite 750, Rockville, MD 20852, (240) 453-8200. Donald Wright, Acting Director, Office of Research Integrity. [FR Doc. 2015-07897 Filed 4-6-15; 8:45 am] BILLING CODE CODE 4150-31-P
![18638 Federal Register / Vol. 80, No. 66 / Tuesday, April 7, 2015 / Notices
RECORD SOURCE CATEGORIES: were included in five (5) publications and/or peer review committee, or as a
Records are obtained directly from the and three (3) grant applications consultant; and
subject individuals, or from the submitted to NINR, NIH: (3) to request that the following
following sources: educational Behavioural Brain Research 279:112–22, publications be retracted: BBR 2015, JNI
institutions; internship and/or residency 2015 Feb 15 (hereafter referred to as 2014, JNT 2009, JNT 2011, and NS 2014.
training programs; employers; NHSC- ‘‘BBR 2015’’) FOR FURTHER INFORMATION CONTACT:
approved service sites; critical shortage • Journal of Neuroinflammation 11:13, Acting Director, Office of Research
facilities; schools of nursing; lending 2014 Jan 22 (hereafter referred to as Integrity, 1101 Wootton Parkway, Suite
institutions and loan servicing agencies; ‘‘JNI 2014’’) 750, Rockville, MD 20852, (240) 453–
health professional associations; • Journal of Neurotrauma 26(4):613–25, 8200.
National Practitioner Data Bank; System 2009 Apr (hereafter referred to as
for Awards Management (formerly Donald Wright,
‘‘JNT 2009’’)
Acting Director, Office of Research Integrity.
Excluded Parties List System); HHS • Journal of Neurotrauma 28(12):2485–
Office of Inspector General Web site 92, 2011 Dec (hereafter referred to as [FR Doc. 2015–07896 Filed 4–6–15; 8:45 am]
listing of individuals excluded from ‘‘JNT 2011’’) BILLING CODE CODE 4150–31–P
Medicare, Medicaid, and all other • Neuroscience 262:143–55, 2014 Mar
federal health care programs; HHS 14 (hereafter referred to as ‘‘NS 2014’’)
database of Health Professional Shortage • R01 NR011167–01 DEPARTMENT OF HEALTH AND
Areas; HHS grantees and contractors/ • R01 NR011167–01A1 HUMAN SERVICES
subcontractors; consumer reporting • R01 NR 011167–01A2
agencies/credit bureaus; other federal Office of the Secretary
ORI found that Respondent falsified
agencies, including but not limited to and/or fabricated data by falsely Findings of Research Misconduct
the Department of the Treasury, IRS, reporting the results of Western blot
and the U.S. Postal Service; state health experiments that examined AGENCY: Office of the Secretary, HHS.
professions licensing boards and/or the neuroinflammation, amyloidogenesis, ACTION: Notice.
Federation of State Medical Boards or a and/or cognitive impairment in a rat
similar non-government entity; and SUMMARY: Notice is hereby given that
model of cerebral ischemia. Specifically,
third parties who provide references or the Office of Research Integrity (ORI)
Respondent duplicated, reused, and
other information concerning the has taken final action in the following
falsely relabeled Western blot gel images
subject individual. case:
and claimed they represented different Ryousuke Fujita, Ph.D., Columbia
SYSTEM EXEMPTED FROM CERTAIN PROVISIONS experiments in: University: Based on the report of an
OF THE ACT: • BBR 2015, Figures 2E and 5D investigation conducted by Columbia
None. • JNI 2014, Figures 2A and 2C University (CU) and additional analysis
[FR Doc. 2015–07899 Filed 4–6–15; 8:45 am]
• JNT 2009, Figures 2B and 5 conducted by ORI in its oversight
• JNT 2011, Figure 2 review, ORI found that Dr. Ryousuke
• NS 2014, Figure 4
BILLING CODE CODE 4160–15–P
Fujita, former Postdoctoral Scientist,
• R01 NR011167–01, Figures 5 and 6 Taub Institute for the Aging Brain,
DEPARTMENT OF HEALTH AND • R01 NR011167–01A1, Figures 4A and Departments of Pathology and Cell
HUMAN SERVICES 4B Biology and Neurology, CU Medical
• R01 NR011167–01A2, Figures 4A and
Center, engaged in research misconduct
Office of the Secretary 4B
in research supported by National
As a result of this Agreement, Institute of Neurological Disorders and
Findings of Research Misconduct Respondent will request that the Stroke (NINDS), National Institutes of
AGENCY: Office of the Secretary, HHS. following publications be retracted: BBR Health (NIH), grant R01 NS064433 and
2015, JNI 2014, JNT 2009, JNT 2011, and National Institute of Aging (NIA), NIH,
ACTION: Notice.
NS 2014. grant R01 AG042317.
SUMMARY: Notice is hereby given that Dr. Briones has entered into a ORI found that Respondent engaged
the Office of Research Integrity (ORI) Voluntary Exclusion Agreement in research misconduct by falsifying and
has taken final action in the following (Agreement) and has voluntarily agreed fabricating data for specific protein
case: for a period of three (3) years, beginning expressions in human-induced neuronal
Teresita L. Briones, Ph.D., Wayne on March 12, 2015: (hiN) cells derived skin fibroblasts of
State University: Based on the report of (1) to exclude herself from any Alzheimer’s disease patients and
an inquiry conducted by Wayne State contracting or subcontracting with any unaffected individuals in seventy-four
University (WSU) and additional agency of the United States Government (74) panels included in figures in the
analysis conducted by ORI in its and from eligibility for or involvement following two (2) publications and one
oversight review, ORI found that Dr. in nonprocurement programs of the (1) unpublished manuscript:
Teresita L. Briones, former Associate United States Government referred to as • Cell 146:359–371, 2011 (hereafter
Professor, College of Nursing, WSU, ‘‘covered transactions’’ pursuant to referred to as ‘‘Cell 2011’’).
engaged in research misconduct in HHS’ Implementation (2 CFR part 376 et • Nature 500:45–53, 2013 (hereafter
research supported by National Institute seq) of OMB Guidelines to Agencies on referred to as ‘‘Nature 2013’’).
• ‘‘Human induced neuron models of
mstockstill on DSK4VPTVN1PROD with NOTICES
of Nursing Research (NINR), National Governmentwide Debarment and
Institutes of Health (NIH), grants P30 Suspension, 2 CFR part 180 (collectively APOE4-associated Alzheimer’s disease
NR009014, R01 NR005260, and R01 the ‘‘Debarment Regulations’’); display altered APP endocytosis and
NR007666. (2) to exclude herself voluntarily from processing.’’ Unpublished manuscript.
ORI found that Respondent serving in any advisory capacity to the ORI found that Respondent engaged
intentionally, knowingly, and recklessly U.S. Public Health Service (PHS) in research misconduct by knowingly
engaged in research misconduct by including, but not limited to, service on and intentionally fabricating and
falsifying and/or fabricating data that any PHS advisory committee, board, falsifying research in seventy-four (74)
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![Federal Register / Vol. 80, No. 66 / Tuesday, April 7, 2015 / Notices 18639
panels included in figures in Cell 2011, (2) to exclude himself voluntarily Preparedness Reauthorization Act of
Nature 2013, and the unpublished from serving in any advisory capacity to 2013 (Pub. L. 113–5), the HHS
manuscript. Respondent inflated sample the U.S. Public Health Service (PHS) Secretary, in consultation with the
numbers and data, fabricated numbers including, but not limited to, service on Secretary of the U.S. Department of
for data sets, manipulated enzyme- any PHS advisory committee, board, Homeland Security, established the
linked immunosorbent assay (ELISA) and/or peer review committee, or as a National Advisory Committee on
analysis, mislabelled consultant. Children and Disasters (NACCD). The
immunoflourescent confocal images, FOR FURTHER INFORMATION CONTACT:
purpose of the NACCD is to provide
and manipulated and reused Western advice and consultation to the HHS
Acting Director, Office of Research
blot images. Secretary with respect to the medical
Integrity, 1101 Wootton Parkway, Suite
Specifically, the Respondent 750, Rockville, MD 20852, (240) 453– and public health needs of children in
8200. relation to disasters. The Office of the
• Fabricated numbers for the data Assistant Secretary for Preparedness
presented as a bar graph in nine (9) Donald Wright, and Response (ASPR) provides
panels in Figures S6#, S6H, and S6J Acting Director, Office of Research Integrity. management and administrative
in Cell 2011, Figures 3B and S12 in [FR Doc. 2015–07897 Filed 4–6–15; 8:45 am] oversight to support the activities of the
Nature 2013, and Figures 2F, 4B, 4D, NACCD.
BILLING CODE CODE 4150–31–P
and 4F in the unpublished Background: This public meeting will
manuscript be dedicated to the members voting to
Falsely inflated the sample size of DEPARTMENT OF HEALTH AND approve the report of findings of the
quantitative data presented as bar NACCD Surge Capacity Work Group.
HUMAN SERVICES
graphs in fifty-three (53) panels in Availability of Materials: The meeting
Figures 6B, 7I, and S6J in Cell 2011, Meeting of the National Advisory agenda and materials will be posted on
Figures 3G, 3H, 4C, S10, S11b–h, Committee on Children and Disasters the NACCD Web site at: www.phe.gov/
S12d–f, S13a, S13c, S14b–c, S15b–i, naccd prior to the meeting.
and S16a–f in Nature 2013, and AGENCY: Office of the Secretary, Procedures for Providing Public Input:
Figures 4b, 4d, 4f, 4i, 6c–d, S1n, S1o, Department of Health and Human All written comments must be received
S2a–b, and S4c–k in the unpublished Services. prior to April 29, 2015. Please submit
manuscript ACTION: Notice. comments via the NACCD Contact Form
Falsely manipulated ELISA analysis to located at www.phe.gov/
achieve desired results presented as SUMMARY: As stipulated by the Federal
NACCDComments. Individuals who
bar graphs in nine (9) figure-panels in Advisory Committee Act, the
plan to participate by phone and need
Figure 6B in Cell 2011 and Figures Department of Health and Human
special assistance should submit a
2D, 2E, 3G, 3H, and S10a–d in Nature Services (HHS) is hereby giving notice
request via the NACCD Contact Form
2013 that the National Advisory Committee
located at www.phe.gov/
Falsely inflated the numerical values of on Children and Disasters (NACCD) will
NACCDComments.
the data in Figure 7I in Cell 2011 by be holding a meeting via teleconference.
a factor of 10 to improve results and The meeting is open to the public. Dated: March 18, 2015.
appear consistent with data presented DATES: The April 30, 2015, NACCD Nicole Lurie,
in supplementary information meeting is scheduled from 1:00 p.m. to Assistant Secretary for Preparedness and
published with the paper 2:00 p.m. EST. The agenda is subject to Response.
Falsely reversed the labeling of change as priorities dictate. Please [FR Doc. 2015–07874 Filed 4–6–15; 8:45 am]
immunoflourescent confocal images check the NACCD Web site, located at BILLING CODE CODE P
in Figures 7M and 7N in Cell 2011 WWW.PHE.GOV/NACCD for the most
and Figure S13A in Nature 2013 to up-to-date information on the meeting.
obtain the desired results ADDRESSES: To attend the meeting via
DEPARTMENT OF HEALTH AND
Flipped and resized the Western blot HUMAN SERVICES
teleconference, call toll-free: 1–888–
image for APP panel from Figure 12b
324–4311, international dial-in: 1–517– Indian Health Service
and falsely reused it to represent APP
308–9181. The pass-code is: 4818002.
results under completely different
Please call 15 minutes prior to the Reimbursement Rates for Calendar
experimental conditions in Figure 12c
beginning of the conference call to Year 2015
in Nature 2013
facilitate attendance. Pre-registration is
Dr. Fujita has entered into a Voluntary required for public attendance. AGENCY: Indian Health Service, HHS.
Exclusion Agreement (Agreement) and Individuals who wish to attend the ACTION: Notice.
has voluntarily agreed for a period of meeting should submit an inquiry via
three (3) years, beginning on March 18, the NACCD Contact Form located at SUMMARY: Notice is given that the
2015: www.phe.gov/NACCDComments. Director of the Indian Health Service
(1) to exclude himself from any (IHS), under the authority of sections
FOR FURTHER INFORMATION CONTACT:
contracting or subcontracting with any 321(a) and 322(b) of the Public Health
agency of the United States Government Please submit an inquiry via the NACCD Service Act (42 U.S.C. 248 and 249(b)),
and from eligibility for or involvement Contact Form located at www.phe.gov/ Public Law 83–568 (42 U.S.C. 2001(a)),
NACCDComments.
mstockstill on DSK4VPTVN1PROD with NOTICES
in nonprocurement programs of the and the Indian Health Care
United States Government referred to as SUPPLEMENTARY INFORMATION: Pursuant Improvement Act (25 U.S.C. 1601 et
‘‘covered transactions’’ pursuant to to the Federal Advisory Committee Act seq.), has approved the following rates
HHS’ Implementation (2 CFR part 376 et (FACA) of 1972 (5 U.S.C., Appendix, as for inpatient and outpatient medical
seq) of OMB Guidelines to Agencies on amended), and section 2811A of the care provided by IHS facilities for
Governmentwide Debarment and Public Health Service (PHS) Act (42 Calendar Year 2015 for Medicare and
Suspension, 2 CFR part 180 (collectively U.S.C. 300hh–10a), as added by section Medicaid beneficiaries, and
the ‘‘Debarment Regulations’’); and 103 of the Pandemic and All Hazards beneficiaries of other Federal programs,
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Document Created: 2018-02-21 10:05:22
Document Modified: 2018-02-21 10:05:22
| Category | Regulatory Information | |
| Collection | Federal Register | |
| sudoc Class | AE 2.7: GS 4.107: AE 2.106: | |
| Publisher | Office of the Federal Register, National Archives and Records Administration | |
| Section | Notices | |
| Action | Notice. | |
| Contact | Acting Director, Office of Research Integrity, 1101 Wootton Parkway, Suite 750, Rockville, MD 20852, (240) 453-8200. | |
| FR Citation | 80 FR 18638 |
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