81 FR 14864 - Alternative Approaches for Acute Inhalation Toxicity To Address Global Regulatory and Non-Regulatory Data Requirements; Notice of Webinars; Registration Information

DEPARTMENT OF HEALTH AND HUMAN SERVICES
National Institutes of Health

Federal Register Volume 81, Issue 53 (March 18, 2016)

The National Toxicology Program (NTP) Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM) announces the webinar series, ``Alternative Approaches for Acute Inhalation Toxicity to Address Global Regulatory and Non-Regulatory Data Requirements.'' Webinar speakers will discuss the state of the science of alternative approaches for identifying acute systemic toxicants due to inhalation exposure, and identify knowledge and data gaps that need to be addressed prior to implementation of those approaches.

[Federal Register Volume 81, Number 53 (Friday, March 18, 2016)]
[Notices]
[Pages 14864-14865]
From the Federal Register Online  [www.thefederalregister.org]
[FR Doc No: 2016-06201]


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DEPARTMENT OF HEALTH AND HUMAN SERVICES

National Institutes of Health


Alternative Approaches for Acute Inhalation Toxicity To Address 
Global Regulatory and Non-Regulatory Data Requirements; Notice of 
Webinars; Registration Information

SUMMARY: The National Toxicology Program (NTP) Interagency Center for 
the Evaluation of Alternative Toxicological Methods (NICEATM) announces 
the webinar series, ``Alternative Approaches for Acute Inhalation 
Toxicity to Address Global Regulatory and Non-Regulatory Data 
Requirements.'' Webinar speakers will discuss the state of the science 
of alternative approaches for identifying acute systemic toxicants due 
to inhalation exposure, and identify knowledge and data gaps that need 
to be addressed prior to implementation of those approaches.

DATES: 
    First Webinar: March 29, 2016, from 11 a.m. to 12 p.m. Eastern 
Daylight Time (EDT).
    Subsequent Webinars: Five subsequent webinars will be presented 
monthly through August 2016; dates of the webinars will posted on the 
Web page.
    Registration for Webinars: Registration for each webinar will be 
open during the webinar.

ADDRESSES: Web page: The preliminary agenda, registration, and other 
meeting materials are at http://ntp.niehs.nih.gov/go/inhalation-2016.

FOR FURTHER INFORMATION CONTACT: Dr. Warren Casey, Director, NICEATM; 
email: [email protected]; telephone: (919) 316-4729.

SUPPLEMENTARY INFORMATION:
    Background: Acute systemic toxicity tests are designed to identify 
chemicals that could cause illness or death immediately or shortly 
after a single exposure. This webinar series will explore and discuss 
alternative approaches that could replace, reduce, or refine the use of 
animals for identifying chemicals that may cause acute systemic 
toxicity when inhaled.
    During the webinar series, participants will (1) define when and 
how acute systemic toxicity data are used for assessing inhalation 
toxicity hazard potential for both regulatory and non-regulatory 
testing; (2) review existing alternative approaches for identifying 
chemicals likely to cause acute systemic toxicity via inhalation, which 
could include mechanism-based models (i.e., in vitro and in silico 
approaches); and (3) identify mechanisms of acute toxicity that may 
constitute key events in adverse outcome pathways for acute inhalation 
toxicity.
    The webinar series steering committee is comprised of members from 
government and nongovernment stakeholder organizations including 
NICEATM, People for the Ethical Treatment of Animals, International 
Science Consortium Ltd., The Dow Chemical Company, European Union 
Reference Laboratory for Alternatives to Animal Testing, Simulations 
Plus, Inc., Netherlands Organisation for Applied Scientific Research, 
and U.S. Environmental Protection Agency.
    List of Webinar Topics and Other Information: A link to 
registration and additional information about the webinar series are 
available at http://ntp.niehs.nih.gov/go/inhalation-2016. Dates and 
topics for each webinar will be posted on this page as they are 
finalized.
    Meeting and Registration: The webinars are open to the public, free 
of charge, with attendance limited only by available webcast capacity. 
Individuals who plan to attend the first webinar should register at 
http://ntp.niehs.nih.gov/go/inhalation-2016 by March 29, 2016. 
Subsequent webinars will be convened monthly; registration for any 
webinar will automatically register the viewer for all subsequent 
webinars. Interested individuals are encouraged to visit http://ntp.niehs.nih.gov/go/inhalation-2016 for future webinar dates and 
topics and to stay abreast of the most current information about the 
webinar series.

[[Page 14865]]

    Individuals with disabilities who need accommodation to participate 
in this event should contact Dr. Elizabeth Maull at telephone: (919) 
316-4668 or email: [email protected]. TTY users should contact the 
Federal TTY Relay Service at (800) 877-8339. Requests should be made at 
least five business days in advance of the event.
    Background Information on NICEATM: NICEATM conducts data analyses, 
workshops, independent validation studies, and other activities to 
assess new, revised, and alternative test methods and strategies. 
NICEATM also provides support for the Interagency Coordinating 
Committee on the Validation of Alternative Methods (ICCVAM). The ICCVAM 
Authorization Act of 2000 (42 U.S.C. 285l-3) provides authority for 
ICCVAM and NICEATM in the development of alternative test methods. 
Information about NICEATM and ICCVAM is found at http://ntp.niehs.nih.gov/go/niceatm and http://ntp.niehs.nih.gov/go/iccvam, 
respectively.

    Dated: March 15, 2016.
John R. Bucher,
Associate Director, National Toxicology Program.
[FR Doc. 2016-06201 Filed 3-17-16; 8:45 am]
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