82 FR 42823 - Government-Owned Inventions; Availability for Licensing
DEPARTMENT OF HEALTH AND HUMAN SERVICES
National Institutes of Health Federal Register Volume 82, Issue 175 (September 12, 2017)
National Institutes of Health
Federal Register Volume 82, Issue 175 (September 12, 2017)
| Page Range | 42823-42824 | |
| FR Document | 2017-19313 |
[Federal Register Volume 82, Number 175 (Tuesday, September 12, 2017)] [Notices] [Pages 42823-42824] From the Federal Register Online [www.thefederalregister.org] [FR Doc No: 2017-19313] ----------------------------------------------------------------------- DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Government-Owned Inventions; Availability for Licensing AGENCY: National Institutes of Health, HHS. ACTION: Notice. ----------------------------------------------------------------------- SUMMARY: Government owned intellectual property covering imaging agents with improved renal clearance available for licensing and commercialization. FOR FURTHER INFORMATION CONTACT: Licensing information and copies of the patent applications listed below may be obtained by emailing the indicated licensing contact at the National Heart, Lung, and Blood, Office of Technology Transfer and Development Office of Technology Transfer, 31 Center Drive, Room 4A29, MSC2479, Bethesda, MD 20892-2479; telephone: 301-402-5579. A signed Confidential Disclosure Agreement may be required to receive copies of the patent applications. SUPPLEMENTARY INFORMATION: The inventions listed below are owned by an agency of the U.S. Government and are available for licensing in the U.S. in accordance with 35 U.S.C. 209 and 37 CFR part 404 to achieve expeditious commercialization of results of federally-funded research and development. Foreign patent applications are filed on selected inventions to extend market coverage for companies and may also be available for licensing. A description of the technology available for licensing follows. Evans Blue Dye Derivatives for Serum Albumin Labeling Description of Technology: The invention is an imaging agent and method of its use for imaging blood pools and the lymphatic system. The imaging agent binds with high affinity to serum albumin, the most abundant serum protein, and can be tagged with several isotopes making it suitable for magnetic resonance imaging or positron emission tomographic imaging. To date, only very few blood-pool tracers have been introduced for positron emission tomography. The existing ones have short half-lives (20.4 min for \11\C and 2.05 min for \15\O) and thus can only be used in centers with an in-house cyclotron. Compared with these radiometals, \18\F has the advantages of being a pure position emitter with ideal half-life. It is the dominant radioisotope used for PET imaging for both clinical applications and preclinical investigations. Evans blue dye has been an important tool in many physiological and clinical investigations because of its [[Page 42824]] high affinity for plasma albumin and has been used for a long time in clinical practice for determination of patient plasma volume. The current imaging agent is a truncated form of EB [NEB]) and has the ability to bind albumin with high affinity. The agent is also conjugated to NOTA to enable in vivo labeling with \18\F labeling by the formation of \18\F-aluminum fluoride complex. The NOTA also facilitates radiometal labeling of NEB with either \68\Ga or \64\Cu. The resulting imaging agent does not affect the in vivo behavior of serum albumin such as circulation, extra-vascularization, and turn- over; thus the imaging results will reflect the distribution and metabolism of serum albumin accurately. Potential Commercial Applications:Blood pool imaging. Lymphatic system imaging. Development Stage: In vivo data available. Inventors: Xiaoyuan Chen, Lixin Lang, Gang Niu (all of NIBIB). Intellectual Property: HHS Reference No. E-099-2015/0-US-01 and/0- US-02. U.S. Patent Applications 14/675,364 filed March 31, 2015 and 15/587,948 filed May 5, 2017. Licensing Contact: Michael Shmilovich, Esq, CLP; 301-435-5019; [email protected]. Collaborative Research Opportunity: The National Institute of Environmental Health Sciences seeks statements of capability or interest from parties interested in collaborative research to further develop and evaluate, please contact Cecilia Pazman, Office of Technology Transfer, National Heart, Lung and Blood Institute, [email protected], 301-594-4273. Dated: September 7, 2017. Michael Shmilovich, Senior Licensing and Patenting Manager, National Heart, Lung, and Blood Institute, Office of Technology Transfer and Development. [FR Doc. 2017-19313 Filed 9-11-17; 8:45 am] BILLING CODE 4140-01-P
![Federal Register / Vol. 82, No. 175 / Tuesday, September 12, 2017 / Notices 42823
TOTAL ESTIMATED ANNUALIZED BURDEN HOURS—Continued
Number of Average burden Total burden
Number of Total
Form name responses per per response hours
respondents responses
respondent (in hours) (rounded up)
Missing Report Form ......................................................... 29 1 29 .08 3
Subject Statement and Dispute ......................................... 3,547 1 3,547 .75 2,661
Request for Dispute Resolution ......................................... 99 1 99 8 792
Electronic Transfer of Funds (EFT) Authorization ............. 654 1 654 .08 53
Authorized Agent Designation ........................................... 213 1 213 .25 54
Account Discrepancy ......................................................... 10 1 10 .25 3
New Administrator Request ............................................... 3,016 1 3,016 .08 242
Query Credit Purchase ...................................................... 789 1 789 .08 64
Educational Request .......................................................... 10 1 10 .08 1
Account Balance Transfer ................................................. 10 1 10 .08 1
Total ............................................................................ 6,059,761 ........................ 6,059,761 .......................... 326,120
HRSA specifically requests comments Date: October 2, 2017. Transfer and Development Office of
on (1) the necessity and utility of the Time: 8:00 a.m. to 6:00 p.m. Technology Transfer, 31 Center Drive,
proposed information collection for the Agenda: To review and evaluate grant Room 4A29, MSC2479, Bethesda, MD
proper performance of the agency’s applications. 20892–2479; telephone: 301–402–5579.
Place: Residence Inn Bethesda Downtown,
functions, (2) the accuracy of the 7335 Wisconsin Ave., Bethesda, MD 20814.
A signed Confidential Disclosure
estimated burden, (3) ways to enhance Contact Person: Cathy J. Wedeen, Ph.D., Agreement may be required to receive
the quality, utility, and clarity of the Scientific Review Officer, Division of copies of the patent applications.
information to be collected, and (4) the Scientific Review, OD, Eunice Kennedy SUPPLEMENTARY INFORMATION: The
use of automated collection techniques Shriver National Institute of Child Health inventions listed below are owned by an
or other forms of information and Human Development, NIH, DHHS, 6710 agency of the U.S. Government and are
technology to minimize the information B Rockledge Drive, Bethesda, Maryland available for licensing in the U.S. in
collection burden. 20892, 301–435–6878, wedeenc@ accordance with 35 U.S.C. 209 and 37
mail.nih.gov.
CFR part 404 to achieve expeditious
Amy McNulty, (Catalogue of Federal Domestic Assistance commercialization of results of
Acting Director, Division of the Executive Program Nos. 93.864, Population Research; federally-funded research and
Secretariat. 93.865, Research for Mothers and Children;
93.929, Center for Medical Rehabilitation
development. Foreign patent
[FR Doc. 2017–19252 Filed 9–11–17; 8:45 am]
Research; 93.209, Contraception and applications are filed on selected
BILLING CODE 4165–15–P inventions to extend market coverage
Infertility Loan Repayment Program, National
Institutes of Health, HHS) for companies and may also be available
for licensing. A description of the
DEPARTMENT OF HEALTH AND Dated: September 6, 2017.
technology available for licensing
HUMAN SERVICES Michelle Trout,
follows.
Program Analyst, Office of Federal Advisory
National Institutes of Health Committee Policy. Evans Blue Dye Derivatives for Serum
[FR Doc. 2017–19232 Filed 9–11–17; 8:45 am] Albumin Labeling
Eunice Kennedy Shriver National
Institute of Child Health and Human BILLING CODE 4140–01–P Description of Technology: The
Development; Notice of Closed invention is an imaging agent and
Meeting method of its use for imaging blood
DEPARTMENT OF HEALTH AND pools and the lymphatic system. The
Pursuant to section 10(d) of the HUMAN SERVICES imaging agent binds with high affinity
Federal Advisory Committee Act, as to serum albumin, the most abundant
amended, notice is hereby given of the National Institutes of Health serum protein, and can be tagged with
following meeting. Government-Owned Inventions; several isotopes making it suitable for
The meeting will be closed to the Availability for Licensing magnetic resonance imaging or positron
public in accordance with the emission tomographic imaging. To date,
provisions set forth in sections AGENCY: National Institutes of Health, only very few blood-pool tracers have
552b(c)(4) and 552b(c)(6), Title 5 U.S.C., HHS. been introduced for positron emission
as amended. The grant applications and ACTION: Notice. tomography. The existing ones have
the discussions could disclose short half-lives (20.4 min for 11C and
confidential trade secrets or commercial SUMMARY: Government owned 2.05 min for 15O) and thus can only be
property such as patentable material, intellectual property covering imaging used in centers with an in-house
and personal information concerning agents with improved renal clearance cyclotron. Compared with these
pmangrum on DSK3GDR082PROD with NOTICES1
individuals associated with the grant available for licensing and radiometals, 18F has the advantages of
applications, the disclosure of which commercialization. being a pure position emitter with ideal
would constitute a clearly unwarranted FOR FURTHER INFORMATION CONTACT: half-life. It is the dominant radioisotope
invasion of personal privacy. Licensing information and copies of the used for PET imaging for both clinical
Name of Committee: National Institute of patent applications listed below may be applications and preclinical
Child Health and Human Development Initial obtained by emailing the indicated investigations. Evans blue dye has been
Review Group; Developmental Biology licensing contact at the National Heart, an important tool in many physiological
Subcommittee. Lung, and Blood, Office of Technology and clinical investigations because of its
VerDate Sep<11>2014 15:19 Sep 11, 2017 Jkt 241001 PO 00000 Frm 00043 Fmt 4703 Sfmt 4703 E:\FR\FM\12SEN1.SGM 12SEN1](https://thefederalregister.org/doc/82_FR_42998/page/1.svg)
![42824 Federal Register / Vol. 82, No. 175 / Tuesday, September 12, 2017 / Notices
high affinity for plasma albumin and provisions set forth in sections MSC 7818, Bethesda, MD 20892, 301–435–
has been used for a long time in clinical 552b(c)(4) and 552b(c)(6), Title 5 U.S.C., 1198, sahaia@csr.nih.gov.
practice for determination of patient as amended. The grant applications and (Catalogue of Federal Domestic Assistance
plasma volume. The current imaging the discussions could disclose Program Nos. 93.306, Comparative Medicine;
agent is a truncated form of EB [NEB]) confidential trade secrets or commercial 93.333, Clinical Research, 93.306, 93.333,
93.337, 93.393–93.396, 93.837–93.844,
and has the ability to bind albumin with property such as patentable material, 93.846–93.878, 93.892, 93.893, National
high affinity. The agent is also and personal information concerning Institutes of Health, HHS)
conjugated to NOTA to enable in vivo individuals associated with the grant
Dated: September 6, 2017.
labeling with 18F labeling by the applications, the disclosure of which
formation of 18F-aluminum fluoride would constitute a clearly unwarranted Natasha M. Copeland,
complex. The NOTA also facilitates invasion of personal privacy. Program Analyst, Office of Federal Advisory
Committee Policy.
radiometal labeling of NEB with either Name of Committee: Center for Scientific
68Ga or 64Cu. The resulting imaging [FR Doc. 2017–19230 Filed 9–11–17; 8:45 am]
Review Special Emphasis Panel; Shared
agent does not affect the in vivo Instrumentation Grants for Flow Cytometers. BILLING CODE 4140–01–P
behavior of serum albumin such as Date: September 26, 2017.
circulation, extra-vascularization, and Time: 11:00 a.m. to 5:00 p.m.
turn-over; thus the imaging results will Agenda: To review and evaluate grant DEPARTMENT OF HEALTH AND
reflect the distribution and metabolism applications. HUMAN SERVICES
Place: National Institutes of Health, 6701
of serum albumin accurately. Rockledge Drive, Bethesda, MD 20892 National Institutes of Health
Potential Commercial Applications: (Virtual Meeting).
• Blood pool imaging. Contact Person: Jonathan Arias, Ph.D., National Institute on Aging; Notice of
• Lymphatic system imaging. Scientific Review Officer, Center for Closed Meetings
Development Stage: Scientific Review, National Institutes of
• In vivo data available. Health, 6701 Rockledge Drive, Room 5170, Pursuant to section 10(d) of the
Inventors: Xiaoyuan Chen, Lixin Lang, MSC 7840, Bethesda, MD 20892, 301–435– Federal Advisory Committee Act, as
Gang Niu (all of NIBIB). 2406, ariasj@csr.nih.gov. amended, notice is hereby given of the
Intellectual Property: HHS Reference Name of Committee: Center for Scientific following meetings.
No. E–099–2015/0–US–01 and/0–US– Review Special Emphasis Panel; Shared and The meetings will be closed to the
02. High-End Mass Spectrometers. public in accordance with the
Date: September 28–29, 2017. provisions set forth in sections
• U.S. Patent Applications Time: 8:00 a.m. to 6:00 p.m.
14/675,364 filed March 31, 2015 and 552b(c)(4) and 552b(c)(6), Title 5 U.S.C.,
Agenda: To review and evaluate grant as amended. The grant applications and
15/587,948 filed May 5, 2017. applications.
Licensing Contact: Michael the discussions could disclose
Place: National Institutes of Health, 6701
Shmilovich, Esq, CLP; 301–435–5019; Rockledge Drive, Bethesda, MD 20892 confidential trade secrets or commercial
shmilovm@nih.gov. (Virtual Meeting). property such as patentable material,
Collaborative Research Opportunity: Contact Person: Sudha Veeraraghavan, and personal information concerning
The National Institute of Environmental Ph.D., Scientific Review Officer, Center for individuals associated with the grant
Health Sciences seeks statements of Scientific Review, National Institutes of applications, the disclosure of which
Health, 6701 Rockledge Drive, Bethesda, MD would constitute a clearly unwarranted
capability or interest from parties 20892, 301–435–1504,
interested in collaborative research to invasion of personal privacy.
sudha.veeraraghavan@nih.gov.
further develop and evaluate, please Name of Committee: National Institute on
Name of Committee: Healthcare Delivery
contact Cecilia Pazman, Office of Aging Special Emphasis Panel; Resource
and Methodologies Integrated Review Group;
Technology Transfer, National Heart, Centers for Minority Aging Research
Nursing and Related Clinical Sciences Study
(RCMAR) ZAG1 ZIJ–9 J1.
Lung and Blood Institute, pazmance@ Section.
Date: October 31–November 1, 2017.
nhlbi.nih.gov, 301–594–4273. Date: October 2–3, 2017.
Time: 5:00 p.m. to 4:00 p.m.
Time: 8:00 a.m. to 5:00 p.m. Agenda: To review and evaluate grant
Dated: September 7, 2017. Agenda: To review and evaluate grant
Michael Shmilovich, applications.
applications. Place: Hyatt Regency Bethesda, One
Senior Licensing and Patenting Manager, Place: Embassy Suites at the Chevy Chase Bethesda Metro Center, Bethesda, MD 20814.
National Heart, Lung, and Blood Institute, Pavilion, 4300 Military Road NW., Contact Person: Carmen Moten, Ph.D.,
Office of Technology Transfer and Washington, DC 20015. MPH, Scientific Review Officer, National
Development. Contact Person: Rafael Semansky, Ph.D., Institute on Aging, Gateway Building, 7201
[FR Doc. 2017–19313 Filed 9–11–17; 8:45 am] Scientific Review Officer, Center for Wisconsin Avenue, Suite 2C212, Bethesda,
Scientific Review, National Institutes of MD 20892, 301–402–7703, cmoten@
BILLING CODE 4140–01–P
Health, 6701 Rockledge Drive, Room 2040M, mail.nih.gov.
Bethesda, MD 20892, 301–496–5749,
semanskyrm@csr.nih.gov. Name of Committee: National Institute on
DEPARTMENT OF HEALTH AND Aging Special Emphasis Panel; Resource
Name of Committee: Center for Scientific Centers for Minority Aging Research
HUMAN SERVICES Review Special Emphasis Panel; Clinical (RCMAR) ZAG1 ZIJ–9 J3.
Studies in Kidney Diseases (PAR–15–161). Date: October 31–November 1, 2017.
National Institutes of Health Date: October 2, 2017. Time: 5:00 p.m. to 4:00 p.m.
Time: 2:00 p.m. to 5:00 p.m. Agenda: To review and evaluate grant
Center for Scientific Review; Notice of
pmangrum on DSK3GDR082PROD with NOTICES1
Agenda: To review and evaluate grant applications.
Closed Meetings applications. Place: Hyatt Regency Bethesda, One
Place: National Institutes of Health, 6701 Bethesda Metro Center, Bethesda, MD 20814.
Pursuant to section 10(d) of the
Rockledge Drive, Bethesda, MD 20892 Contact Person: Carmen Moten, Ph.D.,
Federal Advisory Committee Act, as (Telephone Conference Call). MPH, Scientific Review Officer, National
amended, notice is hereby given of the Contact Person: Atul Sahai, Ph.D., Institute on Aging, Gateway Building, 7201
following meetings. Scientific Review Officer, Center for Wisconsin Avenue, Suite 2C212, Bethesda,
The meetings will be closed to the Scientific Review, National Institutes of MD 20892, 301–402–7703, cmoten@
public in accordance with the Health, 6701 Rockledge Drive, Room 2188, mail.nih.gov.
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Document Created: 2018-10-24 14:13:14
Document Modified: 2018-10-24 14:13:14
| Category | Regulatory Information | |
| Collection | Federal Register | |
| sudoc Class | AE 2.7: GS 4.107: AE 2.106: | |
| Publisher | Office of the Federal Register, National Archives and Records Administration | |
| Section | Notices | |
| Action | Notice. | |
| Contact | Licensing information and copies of the patent applications listed below may be obtained by emailing the indicated licensing contact at the National Heart, Lung, and Blood, Office of Technology Transfer and Development Office of Technology Transfer, 31 Center Drive, Room 4A29, MSC2479, Bethesda, MD 20892-2479; telephone: 301-402-5579. A signed Confidential Disclosure Agreement may be required to receive copies of the patent applications. | |
| FR Citation | 82 FR 42823 |
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