83 FR 13495 - Eunice Kennedy Shriver National Institute of Child Health and Human Development; Notice of Meeting

DEPARTMENT OF HEALTH AND HUMAN SERVICES
National Institutes of Health

Federal Register Volume 83, Issue 61 (March 29, 2018)

Page Range		13495-13495
FR Document		2018-06259

Federal Register, Volume 83 Issue 61 (Thursday, March 29, 2018)

[Federal Register Volume 83, Number 61 (Thursday, March 29, 2018)]
[Notices]
[Page 13495]
From the Federal Register Online  [www.thefederalregister.org]
[FR Doc No: 2018-06259]


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DEPARTMENT OF HEALTH AND HUMAN SERVICES

National Institutes of Health


Eunice Kennedy Shriver National Institute of Child Health and 
Human Development; Notice of Meeting

    Pursuant to section 10(d) of the Federal Advisory Committee Act, as 
amended, notice is hereby given of a meeting of the Board of Scientific 
Counselors, NICHD.
    The meeting will be open to the public as indicated below, with the 
attendance limited to space available. Individuals who plan to attend 
and need special assistance, such as sign language interpretation or 
other reasonable accommodations, should notify the Contact Person 
listed below in advance of the meeting.
    The meeting will be closed to the public as indicated below in 
accordance with the provisions set forth in section 552b(c)(6), Title 5 
U.S.C., as amended for the review, discussion, and evaluation of 
individual intramural programs and projects conducted by the Eunice 
Kennedy Shriver National Institute Of Child Health And Human 
Development, including consideration of personnel qualifications and 
performance, and the competence of individual investigators, the 
disclosure of which would constitute a clearly unwarranted invasion of 
personal privacy.

    Name of Committee: Board of Scientific Counselors, NICHD.
    Date: June 1, 2018.
    Open: 8:00 a.m. to 11:45 a.m.
    Agenda: A report by the Scientific Director, NICHD, on the 
status of the NICHD Division of Intramural Research; talks by 
various intramural scientists, and current organizational structure.
    Place: National Institutes of Health, Building 31A, Conference 
Room 2A48, 31 Center Drive, Bethesda, MD 20892.
    Closed: 11:45 a.m. to 4:00 p.m.
    Agenda: To review and evaluate personal qualifications and 
performance, and competence of individual investigators.
    Place: National Institutes of Health, Building 31A, Conference 
Room 2A48, 31 Center Drive, Bethesda, MD 20892.
    Contact Person: Constantine A. Stratakis, MD, D(med)Sci, 
Scientific Director, Eunice Kennedy Shriver National Institute of 
Child Health and Human Development, NIH, Building 31A, Room 2A46, 31 
Center Drive, Bethesda, MD 20892, 301-594-5984, 
[email protected].

    Information is also available on the Institute's/Center's home 
page: https://www.nichd.nih.gov/about/meetings/Pages/index.aspx, 
where an agenda and any additional information for the meeting will 
be posted when available.

(Catalogue of Federal Domestic Assistance Program Nos.93.864, 
Population Research; 93.865, Research for Mothers and Children; 
93.929, Center for Medical Rehabilitation Research; 93.209, 
Contraception and Infertility Loan Repayment Program, National 
Institutes of Health, HHS)

    Dated: March 23, 2018.
Michelle Trout,
Program Analyst, Office of Federal Advisory Committee Policy.
[FR Doc. 2018-06259 Filed 3-28-18; 8:45 am]
 BILLING CODE 4140-01-P

Federal Register / Vol. 83, No. 61 / Thursday, March 29, 2018 / Notices 13495

licensing in accordance with 35 U.S.C. September 30, 2016, (NIH Reference No. Name of Committee: Board of Scientific
209 and 37 CFR part 404 to achieve E–165–2015/0,1). Counselors, NICHD.
expeditious commercialization of Date: June 1, 2018.
Publications: Lentiviral protein Open: 8:00 a.m. to 11:45 a.m.
results of federally-funded research and delivery system for RNA-guided genome Agenda: A report by the Scientific Director,
development. Technology description editing, PCT Publication No. WO/2017/ NICHD, on the status of the NICHD Division
follows. 059241, published April 6, 2017. of Intramural Research; talks by various
Lentiviral Protein Delivery System for Licensing Contact: Cristina intramural scientists, and current
Thalhammer-Reyero, Ph.D., M.B.A.; organizational structure.
RNA-Guided Genome Editing Place: National Institutes of Health,
301–435–4507; thalhamc@mail.nih.gov.
Description of Technology: This Building 31A, Conference Room 2A48, 31
Collaborative Research Opportunity: Center Drive, Bethesda, MD 20892.
invention provides an HIV–1-based The National Heart, Lung and Blood
lentiviral vector system for gene Closed: 11:45 a.m. to 4:00 p.m.
Institute is seeking statements of Agenda: To review and evaluate personal
correction strategies involving a capability or interest from parties qualifications and performance, and
homologous recombination with a interested in collaborative research to competence of individual investigators.
variation of the CRISPR/Cas9 system. further develop, evaluate or Place: National Institutes of Health,
Such systems are being explored as commercialize this technology. For Building 31A, Conference Room 2A48, 31
potential therapies for certain hereditary collaboration opportunities, please Center Drive, Bethesda, MD 20892.
diseases. This system comprises (a) a contact Denise Crooks at crooksd@ Contact Person: Constantine A. Stratakis,
lentivirus vector particle comprising a MD, D(med)Sci, Scientific Director, Eunice
mail.nih.gov. Kennedy Shriver National Institute of Child
lentiviral genome which encodes at
least one guide RNA sequence that is Dated: March 22, 2018. Health and Human Development, NIH,
Cristina Thalhammer-Reyero, Building 31A, Room 2A46, 31 Center Drive,
complementary to a first DNA sequence
Bethesda, MD 20892, 301–594–5984,
in a host cell genome, (b) a Cas9 protein, Senior Licensing and Patenting Manager,
stratakc@mail.nih.gov.
and optionally (c) a donor nucleic acid Office of Technology Transfer and
Development, National Heart, Lung, and Information is also available on the
molecule comprising a second DNA Institute’s/Center’s home page: https://
sequence. In addition, the invention Blood Institute.
www.nichd.nih.gov/about/meetings/Pages/
provides a host cell comprising the [FR Doc. 2018–06364 Filed 3–28–18; 8:45 am]
index.aspx, where an agenda and any
foregoing system, as well as a method of BILLING CODE 4140–01–P additional information for the meeting will
altering a DNA sequence in a host cell be posted when available.
comprising contacting a host cell with (Catalogue of Federal Domestic Assistance
the foregoing system. Alternatively, the DEPARTMENT OF HEALTH AND Program Nos.93.864, Population Research;
invention also provides a fusion protein HUMAN SERVICES 93.865, Research for Mothers and Children;
comprising a Cas9 protein and a 93.929, Center for Medical Rehabilitation
National Institutes of Health Research; 93.209, Contraception and
cyclophilin A (CypA) protein, wherein
Infertility Loan Repayment Program, National
the fusion protein binds to the lentivirus Eunice Kennedy Shriver National Institutes of Health, HHS)
vector particle, as well as a lentiviral Institute of Child Health and Human
vector particle comprising such a fusion Dated: March 23, 2018.
Development; Notice of Meeting
protein. Other such lentivirus-based Michelle Trout,
vectors encode a guide RNA, which Pursuant to section 10(d) of the Program Analyst, Office of Federal Advisory
contains a specific sequence that Federal Advisory Committee Act, as Committee Policy.
recognizes a target gene, and a Cas9 amended, notice is hereby given of a [FR Doc. 2018–06259 Filed 3–28–18; 8:45 am]
endonuclease, which cuts at the specific meeting of the Board of Scientific BILLING CODE 4140–01–P
site. However, such systems present Counselors, NICHD.
some problems due to constitutive The meeting will be open to the
expression of Cas9 endonuclease in public as indicated below, with the DEPARTMENT OF HEALTH AND
lentiviral vector-transduced cells and attendance limited to space available. HUMAN SERVICES
the large size of the Cas9 gene. The Individuals who plan to attend and
variation of this invention delivers the need special assistance, such as sign National Institutes of Health
Cas9 endonuclease directly, instead of language interpretation or other Eunice Kennedy Shriver National
the gene encoding the protein. reasonable accommodations, should Institute of Child Health and Human
Potential Commercial Applications: notify the Contact Person listed below Development; Notice of Meeting
Clinical trials for hereditary diseases in advance of the meeting.
such as sickle-cell disease and beta- The meeting will be closed to the Pursuant to section 10(a) of the
thalassemia are good market public as indicated below in accordance Federal Advisory Committee Act, as
opportunities. Gene correction using the with the provisions set forth in section amended (5 U.S.C. App.), notice is
disclosed lentiviral vector system are 552b(c)(6), Title 5 U.S.C., as amended hereby given of a meeting of the
being tested with respect to the beta- for the review, discussion, and National Advisory Board on Medical
globin gene and the BCL11A gene to evaluation of individual intramural Rehabilitation Research. The meeting
treat sickle-cell disease and will be used programs and projects conducted by the will be open to the public, with
for induced pluripotent stem cell (iPS) Eunice Kennedy Shriver National attendance limited to space available.
generation. Institute Of Child Health And Human Individuals who plan to attend and
sradovich on DSK3GMQ082PROD with NOTICES

Development Stage: Early-stage. In Development, including consideration need special assistance, such as sign
vitro data in cell-line models available. of personnel qualifications and language interpretation or other
Inventors: Naoya Uchida, Juan J. Haro performance, and the competence of reasonable accommodations, should
Mora and John F. Tisdale (NHLBI). individual investigators, the disclosure notify the Contact Person listed below
Intellectual Property: US Application of which would constitute a clearly in advance of the meeting.
No. 62/236,223, filed October 2, 2015 unwarranted invasion of personal Name of Committee: National Advisory
and PCT/US2016/054759, filed privacy. Board on Medical Rehabilitation Research.

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Document Created: 2018-03-29 00:25:51
Document Modified: 2018-03-29 00:25:51

Category		Regulatory Information
Collection		Federal Register
sudoc Class		AE 2.7: GS 4.107: AE 2.106:
Publisher		Office of the Federal Register, National Archives and Records Administration
Section		Notices
Dates		June 1, 2018.
FR Citation		83 FR 13495

83 FR 13495 - Eunice Kennedy Shriver National Institute of Child Health and Human Development; Notice of Meeting

DEPARTMENT OF HEALTH AND HUMAN SERVICESNational Institutes of Health

Federal Register Volume 83, Issue 61 (March 29, 2018)

DEPARTMENT OF HEALTH AND HUMAN SERVICES
National Institutes of Health