Department of Health and Human Services
National Institutes of Health
An opportunity is available for a Cooperative Research and Development Agreement (CRADA) for the purpose of collaborating with the Screening Technology Branch, National Cancer Institute (STB, NCI) on further research and development of U.S. government-owned technology encompassed within U.S. Provisional Patent Application Serial No. 60/161,533, entitled “B-Homoestra-1,3,5(10)-trienes as Modulators of Tubulin Polymerization.”
AGENCY:
National Cancer Institute, National Institutes of Health, PHS, DHHS.
ACTION:
Notice of opportunity for cooperative research and development (CRADA).
SUMMARY:
Pursuant to the Federal Technology Transfer Act of 1986 (FTTA, 15 U.S.C. 3710; and Executive Order 12591 of April 10, 1987, as amended by the National Technology Transfer and Advancement Act of 1995), the National Cancer Institute (NCI) of the National Institutes of Health (NIH) of the Public Health Service (PHS) of the Department of Health and Human Services (DHHS) seeks a Cooperative Research and Development Agreement (CRADA) with a pharmaceutical or biotechnology company to develop new drugs and therapeutic methods based on screening pre-existing steroid libraries from the collaborator for paclitaxel-like activities and/or screening steroid derivatives from a directed synthetic effort by the collaborator to produce more active paclitaxel-like compounds. The CRADA would have an expected duration of one (1) to five (5) years. The goals of the CRADA include the rapid publication of research results and timely commercialization of products or methods of treatment that may result from the research. The CRADA Collaborator will have an option to negotiate the terms of an exclusive or non-exclusive commercialization license to subject inventions arising under the CRADA and which are subject of the CRADA Research Plan, and can apply for background licenses to the existing patent described above, subject to any pre-existing licenses already issued for other fields of use. Dr. Mark Cushman of Purdue University is a co-inventor on the U.S. Provisional Patent Application Serial No. 60/161,533, entitled “B-Homoestra-1,3,5(10)-trienes as Modulators of Tubulin Polymerization.” Therefore, it is anticipated that negotiations with Purdue University regarding their interest in the original patent application would be required if the potential CRADA collaborator required exclusive rights to the technology encompassed by this patent.
ADDRESSES:
Proposals and questions about this CRADA opportunity may be addressed to Dr. Bjarne Gabrielsen, Technology Development & Commercialization Branch, National Cancer Institute-Frederick Cancer Research & Development Center, Fairview Center, Room 502, Frederick, MD 21701 (phone: 301-846-5465, fax: 301-846-6820).
Scientific inquiries should be directed to Dr. Ernest Hamel, Senior Investigator, Screening Technology Branch, National Cancer Institute-Frederick Cancer Research & Development Center, Bldg. 469, Rm. 237, Frederick, MD 21702-1201 [phone: (301)-846-1678; fax: (301)-846-6014]; e-mail: hamele@dc37a.nci.nih.gov
EFFECTIVE DATE:
Inquiries regarding CRADA proposals and scientific matters may be forwarded at any time. Confidential preliminary CRADA proposals, preferably two pages or less, must be submitted to the NCI on or before June 20, 2000. Guidelines for preparing final CRADA proposals will be communicated shortly thereafter to all respondents with whom initial confidential discussions will have established sufficient mutual interest.