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Government-Owned Inventions; Availability for Licensing
The invention listed below is owned by an agency of the U.S. Government and is available for licensing to achieve expeditious commercialization of results of federally-funded re...
SUPPLEMENTARY INFORMATION:
Technology description follows:
Base-Covered HIV-1 Envelope Ectodomains and Their Use
Description of Technology:
Researchers at the Vaccine Research Center (“VRC”) of the National Institute of Allergy and Infectious Diseases (“NAID”) continue to pursue a safe and effective HIV-1 vaccine to combat the HIV-1/AIDS pandemic.
To this end, researchers have engineered the soluble HIV-1 ectodomain trimer so that it is stabilized in its prefusion conformation by artificial disulfides, helix-disrupting prolines, and other structure-based alterations. However, mice and non-human primates immunized with these engineered soluble HIV-1 trimers produced a significant (>90% in some cases) immune response to the exposed trimer base.
VRC researchers further modified the engineered prefusion soluble HIV-1 trimers by adding N-linked glycans to specific sites on the protein's base to block this immunodominant surface. They found that these N-linked glycans did reduce production of non-neutralizing antibodies directed to the trimer base. These soluble, glycan-masked prefusion HIV-1 trimers are envisioned as being a part of a heterologous prime-boost vaccine regimen.
This technology is available for licensing for commercial development in accordance with 35 U.S.C. 209 and 37 CFR part 404, as well as further development and evaluation under a research collaboration.
Potential Commercial Applications:
- Vaccine for prevention of HIV-1 infection
- Therapeutic vaccine for treatment of HIV-1 infection
Competitive Advantages:
- Currently, no licensed HIV vaccine exists
Development Stage:
Inventors:
Peter Kwong, John Mascola, Tongqing Zhou, Adam Olia, Reda Rawi, Yongping Yang, Cheng Cheng (all of NIAID).
Publications:
Olia, et al. (2023) Soluble prefusion-closed HIV-envelope trimers with glycan-covered bases. iScience
26,
107403, August 18, 2023. DOI:
https://doi.org/10.1016/j.sci.2023.107403.
Intellectual Property:
HHS Reference Number E-079-2022 includes PCT Patent Application No. PCT/US2023/065009 filed on March 27, 2023.
Licensing Contact:
To license this technology, please contact Amy F. Petrik, Ph.D., 240-627-3721;
amy.petrik@nih.gov,
and reference E-079-2022.
Surekha Vathyam,
Deputy Director, Technology Transfer and Intellectual Property Office, National Institute of Allergy and Infectious Diseases.