Significant New Use Rules on Certain Chemical Substances (25-2.5e)
EPA is issuing significant new use rules (SNURs) under the Toxic Substances Control Act (TSCA) for certain chemical substances that were the subject of premanufacture notices (P...
EPA is issuing significant new use rules (SNURs) under the Toxic Substances Control Act (TSCA) for certain chemical substances that were the subject of premanufacture notices (PMNs) and are also subject to an Order issued by EPA pursuant to TSCA. The SNURs require persons to notify EPA at least 90 days before commencing the manufacture (defined by statute to include import) or processing of any of these chemical substances for an activity that is designated as a significant new use in the SNUR. The required notification initiates EPA's evaluation of the conditions of that use for that chemical substance. In addition, the manufacture or processing for the significant new use may not commence until EPA has conducted a review of the required notification; made an appropriate determination regarding that notification; and taken such actions as required by that determination.
DATES:
This rule is effective on July 28, 2026. For purposes of judicial review, this rule shall be promulgated at 1 p.m. (EST) on June 12, 2026.
ADDRESSES:
The docket for this action, identified under docket identification (ID) number EPA-HQ-OPPT-2025-0314, is available online at
https://www.regulations.gov
or in person at the Office of Pollution Prevention and Toxics Docket (OPPT Docket) in the Environmental Protection Agency Docket Center (EPA/DC). Please review the visitor instructions and additional information about the docket available at
https://www.epa.gov/dockets.
FOR FURTHER INFORMATION CONTACT:
For technical information:
Punam Tyagi, New Chemicals Division (7405M), Office of Pollution Prevention and Toxics, Environmental Protection Agency, 1200 Pennsylvania Ave. NW, Washington, DC 20460-0001; telephone number: (202) 566-1176; email address:
tyagi.punam@epa.gov.
For general information on SNURs:
William Wysong, New Chemicals Division (7405M), Office of Pollution Prevention and Toxics, Environmental
( printed page 31963)
Protection Agency, 1200 Pennsylvania Ave. NW, Washington, DC 20460-0001; telephone number: (202) 564-4163; email address:
wysong.william@epa.gov.
For general information on TSCA:
The TSCA Assistance Information Service Hotline, Goodwill of the Finger Lakes, 422 South Clinton Ave., Rochester, NY 14620; telephone number: (202) 554-1404; email address:
TSCA-Hotline@epa.gov.
SUPPLEMENTARY INFORMATION:
I. Executive Summary
A. What is the Agency's authority for taking this action?
TSCA section 5(a)(2) (15 U.S.C. 2604(a)(2)) authorizes EPA to determine that a use of a chemical substance is a “significant new use.” EPA must make this determination by rule after considering all relevant factors, including the factors in TSCA section 5(a)(2).
B. What action is the Agency taking?
EPA is finalizing SNURs under TSCA section 5(a)(2) for the chemical substances identified in this document. These chemical substances were the subject of PMNs and are also subject to an Order issued by EPA pursuant to TSCA section 5(e)(1)(A), as required by the determinations made under TSCA section 5(a)(3)(B). The SNURs identify as significant new uses any manufacturing, processing, use, distribution in commerce, or disposal that does not conform to the restrictions imposed by the underlying TSCA Orders, consistent with TSCA section 5(f)(4). The SNURs require persons who intend to manufacture or process any of these chemical substances for an activity that is designated as a significant new use in the SNURs to notify EPA at least 90 days before commencing that activity.
Previously, EPA proposed SNURs for these chemical substances in the
Federal Register
of November 3, 2025 (90 FR 49180 (FRL-12931-01-OCSPP)). The docket includes information considered by the Agency in developing the proposed and final rules, including public comments and EPA's responses to the comments received as discussed in Unit II.D.
C. Does this action apply to me?
1. General Applicability
This action applies to you if you manufacture, process, or use the chemical substances identified in this document. The following list of North American Industrial Classification System (NAICS) codes is not intended to be exhaustive, but rather provides a guide to help readers determine whether this document applies to them. Potentially affected entities may include:
Manufacturers or processors of one or more subject chemical substances (NAICS codes 325 and 324110),e.g.,
chemical manufacturing and petroleum refineries.
Chemical importers are subject to TSCA section 13 (15 U.S.C. 2612), the requirements in 19 CFR 12.118 through 12.127, 19 CFR 127.28, and 40 CFR part 707, subpart B. Importers of chemical substances in bulk form, as part of a mixture, or as part of an article (if required by rule) must certify that the shipment of the chemical substance complies with all applicable rules and orders under TSCA, including regulations issued under TSCA sections 5, 6, 7 and Title IV.
Pursuant to 40 CFR 721.20, any persons who export or intend to export a chemical substance identified in this document are subject to the export notification provisions of TSCA section 12(b) (15 U.S.C. 2611(b)) and must comply with the export notification requirements in 40 CFR part 707, subpart D.
D. What are the incremental economic impacts of this action?
EPA has evaluated the potential costs of establishing SNUN reporting requirements for potential manufacturers and processors of the chemical substances identified in this document. This analysis, which is available in the docket, is briefly summarized here.
1. Estimated Costs for SNUN Submissions
A SNUR requires that any person who intends to engage in such activity in the future must first notify EPA by submitting a SNUN. If a SNUN is submitted, costs are an estimated $45,000 per SNUN submission for large business submitters and $14,500 for small business submitters. These estimates include the cost to prepare and submit the SNUN (including registration for EPA's Central Data Exchange (CDX)), and the payment of a user fee. Businesses that submit a SNUN would be subject to either a $37,000 user fee required by 40 CFR 700.45(c)(2)(ii) and (d), or, if they are a small business as defined at 13 CFR 121.201, a reduced user fee of $6,480 (40 CFR 700.45(c)(1)(ii) and (d)). These estimates reflect the costs and fees as they are known at the time of this rulemaking.
2. Estimated Costs for Export Notifications
EPA has also evaluated the potential costs associated with the pre-existing export notification requirements under TSCA section 12(b) and the implementing regulations at 40 CFR part 707, subpart D. For persons exporting a substance that is the subject of a SNUR, a one-time notice to EPA must be provided for the first export or intended export to a particular country. The total costs of export notification will vary by chemical, depending on the number of required notifications (
i.e.,
the number of countries to which the chemical is exported). While EPA is unable to make any estimate of the likely number of export notifications for the chemical substances covered by these SNURs, as stated in the accompanying economic analysis, the estimated cost of the export notification requirement on a per unit basis is approximately $106.
B. Applicability of the Significant New Use Designation
To establish a significant new use, EPA must determine that the use is not ongoing. As discussed in Unit II.E. of the proposed rule, EPA concluded that the proposed significant new uses were not ongoing. If EPA subsequently determines that such a use was ongoing as of the date of publication of the proposed rule and did not cease prior to issuance of the final rule, EPA will not designate that use as a significant new use in the final rule. EPA has no information to suggest that any of the significant new uses identified in this rule meet this criterion.
As discussed in the
Federal Register
of April 24, 1990 (55 FR 17376 (FRL-3658-5)), EPA believes that the intent of TSCA section 5(a)(1)(B) is best served by designating a use as a significant new use as of the date of publication of the proposed rule rather than as of the effective date of the final rule. The objective of EPA's approach is to ensure
( printed page 31964)
that a person cannot impede finalization of a SNUR by initiating a significant new use after publication of the proposed rule but before the effective date of the final rule. Uses arising after the publication of the proposed rule are distinguished from uses that are identified in the final rule as having been ongoing on the date of publication of the proposed rule. The former would be new uses, the latter ongoing uses, except that uses that are identified as ongoing as of the publication of the proposed rule would not be considered ongoing uses if they have ceased by the date of issuance of a final rule.
In the unlikely event that before a final rule becomes effective a person begins commercial manufacturing (including importing) or processing of the chemical substances for a use that is designated as a significant new use in that final rule, such a person would have to cease any such activity upon the effective date of the final rule. To resume their activities, these persons would have to first comply with all applicable SNUR notification requirements and wait until all TSCA prerequisites for the commencement of manufacture or processing have been satisfied.
Issuance of a SNUR for a chemical substance does not signify that the chemical substance is listed on the TSCA Chemical Substance Inventory (TSCA Inventory). Guidance on how to determine if a chemical substance is on the TSCA Inventory is available on the internet at
https://www.epa.gov/tsca-inventory.
EPA recognizes that TSCA section 5 does not require development of any particular new information (
e.g.,
generating test data) before submission of a SNUN. There is an exception: If a person is required to submit information for a chemical substance pursuant to a rule, order or consent agreement under TSCA section 4, then TSCA section 5(b)(1)(A) requires such information to be submitted to EPA at the time of submission of the SNUN.
In the absence of a rule, TSCA order, or consent agreement under TSCA section 4 covering the chemical substance, persons are required only to submit information in their possession or control and to describe any other information known to or reasonably ascertainable by them (see 40 CFR 720.50). However, upon review of PMNs and SNUNs, the Agency has the authority to require appropriate testing. To assist with EPA's analysis of the SNUN, submitters are encouraged, but not required, to provide the potentially useful information as identified for the chemical substance in Unit III.C. of the proposed rule.
EPA strongly encourages persons, before performing any testing, to consult with the Agency pertaining to protocol selection. Furthermore, pursuant to TSCA section 4(h), which pertains to reduction of testing in vertebrate animals, EPA encourages consultation with the Agency on the use of alternative test methods and strategies (also called New Approach Methodologies, or NAMs), if available, to generate the recommended test data. EPA encourages dialog with Agency representatives to help determine how best the submitter can meet both the data needs and the objective of TSCA section 4(h). For more information on alternative test methods and strategies to reduce vertebrate animal testing, visit
https://www.epa.gov/assessing-and-managing-chemicals-under-tsca/alternative-test-methods-and-strategies-reduce.
The potentially useful information described in Unit III. of the proposed rule may not be the only means of providing information to evaluate the chemical substance associated with the significant new uses. However, submitting a SNUN without any test data may increase the likelihood that EPA will take action under TSCA sections 5(e) or 5(f). EPA recommends that potential SNUN submitters contact EPA early enough so that they will be able to conduct the appropriate tests.
SNUN submitters should be aware that EPA will be better able to evaluate SNUNs which provide detailed information about human exposure and environmental release that may result from the significant new use of the chemical substances.
D. Public Comments on Proposed Rule and EPA Responses
EPA received public comments on the proposed SNURs and prepared a Response to Comment document that provides the Agency responses. The comments and the Response to Comment document are available in the docket. As described in the Response to Comment document, EPA is finalizing these SNURs with the following change (listed by PMN Number and proposed 40 CFR citation):
For PMN P-18-413 (40 CFR 721.12185), EPA removed “unless or until the article has been shredded or processed such that exposure to the chemical substance occurs” from paragraph (a)(1) of the SNUR because that language does not appear in the underlying Order and was included in the proposed rule inadvertently. The last sentence of paragraph (a)(1) of the SNUR now reads: “The requirements of this section do not apply to quantities of the chemical substance after they have been completely entrained in a sealed battery or sealed supercapacitor.”
In addition to the change to respond to comments, EPA identified the need to revise the following proposed SNURs (listed by PMN Number and proposed 40 CFR citation):
For P-18-104 (40 CFR 721.12184), to improve clarity, EPA revised the wording of paragraph (a)(2)(iii) by separating the first sentence into two sentences, which now read: “It is a significant new use to manufacture the substance other than by import into the United States (
i.e.,
no domestic manufacture). It is a significant new use to manufacture the substance above the confidential percentage in formulation specified in the Order.”
For P-24-4 (40 CFR 721.12202), EPA replaced the generic chemical name with the specific chemical name and CASRN because the CBI claim for this information has been relinquished by the PMN submitter.
For P-24-102 (40 CFR 721.12206) and P-24-103 (40 CFR 721.12207), EPA updated the generic chemical names to reflect changes negotiated with the notice submitter(s) at the time EPA received Notices of Commencement of Manufacture or Import (NOCs) for the substances.
III. Chemical Substances Subject to These SNURs
A. What is the designated cutoff date for ongoing uses?
EPA designates the date of publication of the proposed rule as the cutoff date for determining whether the new use is ongoing,
i.e.,
November 3, 2025 (90 FR 49180 (FRL-12931-01-OCSPP)). This designation is explained in more detail in Unit II.B.
( printed page 31965)
B. What information was provided for each chemical substance?
In Unit III.C. of the proposed rule, EPA provided the following information for each chemical substance subject to these SNURs:
PMN number (the CFR citation assigned in the regulatory text section of this document).
Chemical name (generic name, if the specific name is claimed as CBI).
Chemical Abstracts Service Registry Number (CASRN) or Accession Number (if assigned, for confidential chemical identities).
Basis for the SNUR (e.g.,
effective date of and basis for the TSCA Order).
Potentially useful information.
The regulatory text section of this document specifies the chemical substances and activities designated as significant new uses. Certain new uses, including production volume limits and other uses designated, may be claimed as CBI, as discussed in more detail in Unit II.C. of the proposed rule.
In addition, as discussed in Unit III.B. of the proposed rule, these SNURs include PMN substances that are subject to orders issued under TSCA section 5(e)(1)(A), as required by the determinations made under TSCA section 5(a)(3)(B). Those TSCA Orders require protective measures to limit exposures or otherwise mitigate the potential unreasonable risk. As such, the SNURs identify as significant new uses any manufacturing, processing, use, distribution in commerce, or disposal that does not conform to the restrictions imposed by the underlying TSCA Orders, consistent with TSCA section 5(f)(4).
This action establishes SNURs for new chemical substances that were the subject of PMNs. The Office of Management and Budget (OMB) has exempted these types of actions from review under Executive Order 12866 (58 FR 51735, October 4, 1993).
According to the PRA (44 U.S.C. 3501et seq.), an agency may not conduct or sponsor, and a person is not required to respond to a collection of information that requires OMB approval under PRA, unless it has been approved by OMB and displays a currently valid OMB control number. The OMB control numbers for EPA's regulations in title 40 of the CFR, after appearing in the
Federal Register
, are listed in 40 CFR part 9, and included on the related collection instrument or form, if applicable.
The information collection requirements related to SNURs have already been approved by OMB pursuant to PRA under OMB control number 2070-0038 (EPA ICR No. 1188). This action does not impose any burden requiring additional OMB approval. If an entity were to submit a SNUN to the Agency, the annual burden is estimated to average between 30 and 170 hours per submission. This burden estimate includes the time needed to review instructions, search existing data sources, gather and maintain the data needed, and complete, review, and submit the required SNUN.
D. Regulatory Flexibility Act (RFA)
I certify that this action will not have a significant economic impact on a substantial number of small entities under the RFA (5 U.S.C. 601et seq.). The requirement to submit a SNUN applies to any person (including small or large entities) who intends to engage in any activity described in the final rule as a “significant new use.” Because these uses are “new,” based on all information currently available to EPA, EPA has concluded that no small or large entities presently engage in such activities.
A SNUR requires that any person who intends to engage in such activity in the future must first notify EPA by submitting a SNUN. Although some small entities may decide to pursue a significant new use in the future, EPA cannot presently determine how many, if any, there may be. However, EPA's experience to date is that, in response to the promulgation of SNURs covering over 1,000 chemicals, the Agency receives only a small number of notices per year. For example, the number of SNUNs received was 7 in Federal fiscal year (FY) 2020, 9 in FY2021, 9 in FY2022, 23 in FY2023, and 7 in FY2024, and only a fraction of these submissions were from small businesses.
In addition, the Agency currently offers relief to qualifying small businesses by reducing the SNUN submission fee from $37,000 to $6,480. This lower fee reduces the total reporting and recordkeeping cost of submitting a SNUN to about $14,500 per SNUN submission for qualifying small firms. Therefore, the potential economic impacts of complying with these proposed SNURs are not expected to be significant or adversely impact a substantial number of small entities. In a SNUR that published in the
Federal Register
of June 2, 1997 (62 FR 29684 (FRL-5597-1)), the Agency presented its general determination that SNURs are not expected to have a significant economic impact on a substantial number of small entities, which was provided to the Chief Counsel for Advocacy of the Small Business Administration.
E. Unfunded Mandates Reform Act (UMRA)
This action does not contain an unfunded mandate of $100 million or more (in 1995 dollars) in any one year as described in UMRA, 2 U.S.C. 1531-1538, and does not significantly or uniquely affect small governments. Based on EPA's experience with proposing and finalizing SNURs, State, local, and Tribal governments have not been impacted by SNURs, and EPA does not have any reasons to believe that any State, local, or Tribal government will be impacted by these SNURs. In addition, the estimated costs of this action to the private sector do not exceed $183 million or more in any one year (the 1995 dollars are adjusted to 2023 dollars for inflation using the GDP implicit price deflator). The estimated costs for this action are discussed in Unit I.D.
This action will not have federalism implications as specified in Executive Order 13132 (64 FR 43255, August 10, 1999), because it is not expected to have a substantial direct effect on States, on the relationship between the national government and the States, or on the distribution of power and responsibilities among the various levels of government. Accordingly, the requirements of Executive Order 13132 do not apply to this action.
G. Executive Order 13175: Consultation and Coordination With Indian Tribal Governments
This action will not have Tribal implications as specified in Executive Order 13175 (65 FR 67249, November 9, 2000), because it is not expected to have substantial direct effects on Indian Tribes, significantly or uniquely affect
( printed page 31966)
the communities of Indian Tribal governments and does not involve or impose any requirements that affect Indian Tribes. Accordingly, the requirements of Executive Order 13175 do not apply to this action.
H. Executive Order 13045: Protection of Children From Environmental Health Risks and Safety Risks
This action is not subject to Executive Order 13045 (62 FR 19885, April 23, 1997), because it does not concern an environmental health or safety risk. Since this action does not concern a human health risk, EPA's 2021 Policy on Children's Health also does not apply. Although the establishment of these SNURs do not address an existing children's environmental health concern because the chemical uses involved are not ongoing uses, SNURs require that persons notify EPA at least 90 days before commencing manufacture (defined by statute to include import) or processing of the identified chemical substances for an activity that is designated as a significant new use by the SNUR. This notification allows EPA to assess the intended uses to identify potential risks and take appropriate actions before the activities commence.
I. Executive Order 13211: Actions Concerning Regulations That Significantly Affect Energy Supply, Distribution, or Use
This action is not a “significant energy action” as defined in Executive Order 13211 (66 FR 28355, May 22, 2001), because it is not likely to have a significant adverse effect on the supply, distribution, or use of energy.
J. National Technology Transfer and Advancement Act (NTTAA)
This action does not involve any technical standards subject to NTTAA section 12(d) (15 U.S.C. 272 note).
K. Congressional Review Act (CRA)
This action is subject to the CRA (5 U.S.C. 801et seq.), and EPA will submit a rule report to each House of the Congress and to the Comptroller General of the United States. This action is not a “major rule” as defined by 5 U.S.C. 804(2).
(a)
Chemical substance and significant new uses subject to reporting.
(1) The chemical substance identified generically as heteroaromatic substituted alkanoic acid, [2,2-bis[[(1-oxo-2-propen-1-yl)oxy]methyl]-1,3-propanediyl] ester, dioxide homopolymer (PMN P-18-104) is
( printed page 31967)
subject to reporting under this section for the significant new uses described in paragraph (a)(2) of this section. The requirements of this section do not apply to quantities of the substance after they have been entrained in the plastic article.
(2) The significant new uses are:
(i)
Protection in the workplace.
Requirements as specified in § 721.63(a)(1), (a)(3) through (6), and (c). When determining which persons are reasonably likely to be exposed as required for § 721.63(a)(1) and (4), engineering control measures (
e.g.,
enclosure or confinement of the operation, general and local ventilation) or administrative control measures (
e.g.,
workplace policies and procedures) shall be considered and implemented to prevent exposure, where feasible. For purposes of § 721.63(a)(5), respirators must provide a National Institute for Occupational Safety and Health (NIOSH) assigned protection factor (APF) of at least 1000.
(ii)
Hazard communication.
Requirements as specified in § 721.72(a) through (d), (f), (g)(1), and (5). For purposes of § 721.72(g)(1), this substance may cause: specific target organ toxicity. Alternative hazard and warning statements that meet the criteria of the Globally Harmonized System and OSHA Hazard Communication Standard may be used.
(iii)
Industrial, commercial, and consumer activities.
It is a significant new use to manufacture the substance other than by import into the United States (
i.e.,
no domestic manufacture). It is a significant new use to manufacture the substance above the confidential percentage in formulation specified in the Order. It is a significant new use to use the substance other than as a halogen-free flame retardant for use in thermoplastic polymers.
(b)
Specific requirements.
The provisions of subpart A of this part apply to this section except as modified by this paragraph (b).
(1)
Recordkeeping.
Recordkeeping requirements as specified in § 721.125(a) through (i) are applicable to manufacturers, importers, and processors of this substance.
(2)
Limitation or revocation of certain notification requirements.
The provisions of § 721.185 apply to this section.
(a)
Chemical substance and significant new uses subject to reporting.
(1) The chemical substance identified as ethanol, 2,2-difluoro-, 1-acetate (PMN P-18-413; CASRN: 1550-44-3) is subject to reporting under this section for the significant new uses described in paragraph (a)(2) of this section. The requirements of this section do not apply to quantities of the chemical substance after they have been completely entrained in a sealed battery or sealed supercapacitor.
(2) The significant new uses are:
(i)
Protection in the workplace.
Requirements as specified in § 721.63(a)(1) and(3) and (c). When determining which persons are reasonably likely to be exposed as required for § 721.63(a)(1), engineering control measures (
e.g.,
enclosure or confinement of the operation, general and local ventilation) or administrative control measures (
e.g.,
workplace policies and procedures) shall be considered and implemented to prevent exposure, where feasible.
(ii)
Hazard communication.
Requirements as specified in § 721.72(a) through (d), (f), (g)(1), (g)(3)(iii), and (g)(5). For purposes of § 721.72(g)(1), this substance may cause: reproductive toxicity, specific target organ toxicity, skin corrosion, and serious eye damage. Alternative hazard and warning statements that meet the criteria of the Globally Harmonized System and OSHA Hazard Communication Standard may be used.
(iii)
Industrial, commercial, and consumer activities.
Requirements as specified in § 721.80(a) through (c).
(iv)
Release to water.
Requirements as specified in § 721.90(a)(4), (b)(4), and (c)(4) where N=554.
(b)
Specific requirements.
The provisions of subpart A of this part apply to this section except as modified by this paragraph (b).
(1)
Recordkeeping.
Recordkeeping requirements as specified in § 721.125(a) through (i), and (k) are applicable to manufacturers, importers, and processors of this substance.
(2)
Limitation or revocation of certain notification requirements.
The provisions of § 721.185 apply to this section.
Heterocyclic epoxide polymer with mixed substituted glycols and acid anhydride (generic).
(a)
Chemical substance and significant new uses subject to reporting.
(1) The chemical substance identified generically as heterocyclic epoxide polymer with mixed substituted glycols and acid anhydride (PMN P-21-88; Accession No. 303458) is subject to reporting under this section for the significant new uses described in paragraph (a)(2) of this section. The requirements of this section do not apply to quantities of the substance after they have been completely reacted or cured (
i.e.,
the substance has been reacted or cured to the extent that no release of the substance can be detected).
(2) The significant new uses are:
(i)
Protection in the workplace.
Requirements as specified in § 721.63(a)(1), (a)(3) through (6), and (c). When determining which persons are reasonably likely to be exposed as required for § 721.63(a)(1) and (4), engineering control measures (
e.g.,
enclosure or confinement of the operation, general and local ventilation) or administrative control measures (
e.g.,
workplace policies and procedures) shall be considered and implemented to prevent exposure, where feasible. For purposes of § 721.63(a)(5), respirators must provide a National Institute for Occupational Safety and Health (NIOSH) assigned protection factor (APF) of at least 1000.
(ii)
Hazard communication.
Requirements as specified in § 721.72(a) through (d), (f), (g)(1), (g)(3)(iii), and (g)(5). For purposes of § 721.72(g)(1), this substance may cause: acute toxicity, skin irritation, serious eye damage, eye irritation, respiratory sensitization, skin sensitization, genetic toxicity, reproductive toxicity, and specific target organ toxicity. Alternative hazard and warning statements that meet the criteria of the Globally Harmonized System and OSHA Hazard Communication Standard may be used.
(iii)
Industrial, commercial, and consumer activities.
It is a significant new use to manufacture the substance as a solid without the use of a fume hood, dust collector, or other engineering controls with at least 25% combined capture and removal efficiency of aggregate releases of the total process, unless in an enclosed process. It is a significant new use to process or use the substance as a solid without the use of a fume hood, dust collector, or other engineering controls with at least 25% combined capture and removal efficiency, unless in an enclosed process.
(iv)
Disposal.
It is a significant new use to dispose of the substance or waste streams containing the substance other than by incineration or hazardous waste landfill in compliance with RCRA subtitle C.
(v)
Release to water.
Requirements as specified in § 721.90(a)(1), (b)(1), and (c)(1).
(b)
Specific requirements.
The provisions of subpart A of this part apply to this section except as modified by this paragraph (b).
(1)
Recordkeeping.
Recordkeeping requirements as specified in
( printed page 31968)
§ 721.125(a) through (k) are applicable to manufacturers, importers, and processors of this substance.
(2)
Limitation or revocation of certain notification requirements.
The provisions of § 721.185 apply to this section.
(a)
Chemical substance and significant new uses subject to reporting.
(1) The chemical substance identified as pyridinium, 3-carboxy-1-methyl-, inner salt (PMN P-21-215; CASRN 535-83-1) is subject to reporting under this section for the significant new uses described in paragraph (a)(2) of this section. The requirements of this section do not apply to quantities of the substance after they have been completely destroyed.
(2) The significant new uses are:
(i)
Protection in the workplace.
Requirements as specified in § 721.63(a)(1) and (3) and (c). When determining which persons are reasonably likely to be exposed as required for § 721.63(a)(1), engineering control measures (
e.g.,
enclosure or confinement of the operation, general and local ventilation) or administrative control measures (
e.g.,
workplace policies and procedures) shall be considered and implemented to prevent exposure, where feasible.
(ii)
Hazard communication.
Requirements as specified in § 721.72(a) through (d), (f), (g)(1), (g)(3)(iii), and (g)(5). For purposes of § 721.72(g)(1), this substance may cause: eye irritation, reproductive toxicity, and specific target organ toxicity. Alternative hazard and warning statements that meet the criteria of the Globally Harmonized System and OSHA Hazard Communication Standard may be used.
(iii)
Industrial, commercial, and consumer activities.
Requirements as specified in § 721.80(o). It is a significant new use to manufacture, process, or use the substance in any manner that results in inhalation exposure.
(iv)
Release to water.
Requirements as specified in § 721.90(a)(4), (b)(4), and (c)(4) where N=770.
(b)
Specific requirements.
The provisions of subpart A of this part apply to this section except as modified by this paragraph (b).
(1)
Recordkeeping.
Recordkeeping requirements as specified in § 721.125(a) through (i), and (k) are applicable to manufacturers, importers, and processors of this substance.
(2)
Limitation or revocation of certain notification requirements.
The provisions of § 721.185 apply to this section.
(a)
Chemical substance and significant new uses subject to reporting.
(1) The chemical substance identified generically as polyol allyl ether, homopolymer terpene ether and polyol allyl ether, homopolymer, alkyl ethers (PMN P-22-60) is subject to reporting under this section for the significant new uses described in paragraph (a)(2) of this section. The requirements of this section do not apply to quantities of the substance when completely reacted, cured, or incorporated into a polymer matrix.
(2) The significant new uses are:
(i)
Protection in the workplac
e. Requirements as specified in § 721.63(a)(1) and (3) and (c). When determining which persons are reasonably likely to be exposed as required for § 721.63(a)(1), engineering control measures (
e.g.,
enclosure or confinement of the operation, general and local ventilation) or administrative control measures (
e.g.,
workplace policies and procedures) shall be considered and implemented to prevent exposure, where feasible.
(ii)
Hazard communication.
Requirements as specified in § 721.72(a) through (d), (f), (g)(1), (g)(3)(iii), and (g)(5). For purposes of § 721.72(g)(1), this substance may cause: acute toxicity, skin corrosion, skin irritation, serious eye damage, eye irritation, respiratory sensitization, skin sensitization, genetic toxicity, carcinogenicity, and specific target organ toxicity. Alternative hazard and warning statements that meet the criteria of the Globally Harmonized System and OSHA Hazard Communication Standard may be used.
(iii)
Industrial, commercial, and consumer activities.
Requirements as specified in § 721.80(o). It is a significant new use to manufacture, process, or use the substance in any manner that results in inhalation exposure to the substance.
(iv)
Disposal.
Requirements as specified in § 721.85(a)(1), (b)(1), and (c)(1).
(v)
Release to water.
Requirements as specified in § 721.90(a)(1), (b)(1), and (c)(1).
(b)
Specific requirements.
The provisions of subpart A of this part apply to this section except as modified by this paragraph (b).
(1)
Recordkeeping.
Recordkeeping requirements as specified in § 721.125(a) through (k) are applicable to manufacturers, importers, and processors of this substance.
(2)
Limitation or revocation of certain notification requirements.
The provisions of § 721.185 apply to this section.
(a)
Chemical substance and significant new uses subject to reporting.
(1) The chemical substance identified generically as polyol allyl ether, homopolymer terpene ether and polyol allyl ether, homopolymer, alkyl ethers (PMN P-22-61) is subject to reporting under this section for the significant new uses described in paragraph (a)(2) of this section. The requirements of this section do not apply to quantities of the substance when completely reacted, cured, or incorporated into a polymer matrix.
(2) The significant new uses are:
(i)
Protection in the workplace.
Requirements as specified in § 721.63(a)(1) and (3) and (c). When determining which persons are reasonably likely to be exposed as required for § 721.63(a)(1), engineering control measures (
e.g.,
enclosure or confinement of the operation, general and local ventilation) or administrative control measures (
e.g.,
workplace policies and procedures) shall be considered and implemented to prevent exposure, where feasible.
(ii)
Hazard communication.
Requirements as specified in § 721.72(a) through (d), (f), (g)(1), (g)(3)(iii), and (g)(5). For purposes of § 721.72(g)(1), this substance may cause: acute toxicity, skin corrosion, skin irritation, serious eye damage, eye irritation, respiratory sensitization, skin sensitization, genetic toxicity, carcinogenicity, and specific target organ toxicity. Alternative hazard and warning statements that meet the criteria of the Globally Harmonized System and OSHA Hazard Communication Standard may be used.
(iii)
Industrial, commercial, and consumer activitie
s. Requirements as specified in § 721.80(o). It is a significant new use to manufacture, process, or use the substance in any manner that results in inhalation exposure to the substance.
(iv)
Disposal.
Requirements as specified in § 721.85(a)(1), (b)(1), and (c)(1).
(v)
Release to water.
Requirements as specified in § 721.90(a)(1), (b)(1), and (c)(1).
(b)
Specific requirements.
The provisions of subpart A of this part apply to this section except as modified by this paragraph (b).
(1)
Recordkeeping.
Recordkeeping requirements as specified in § 721.125(a) through (k) are applicable
( printed page 31969)
to manufacturers, importers, and processors of this substance.
(2)
Limitation or revocation of certain notification requirements.
The provisions of § 721.185 apply to this section.
Polyol allyl ether, polymer with alkylene oxides, terpene ether and polyol allyl ether, polymer with alkylene oxides, alkyl ethers (generic).
(a)
Chemical substance and significant new uses subject to reporting.
(1) The chemical substance identified generically as polyol allyl ether, polymer with alkylene oxides, terpene ether and polyol allyl ether, polymer with alkylene oxides, alkyl ethers (PMN P-22-64) is subject to reporting under this section for the significant new uses described in paragraph (a)(2) of this section. The requirements of this section do not apply to quantities of the substance when completely reacted, cured, or incorporated into a polymer matrix.
(2) The significant new uses are:
(i)
Protection in the workplace.
Requirements as specified in § 721.63(a)(1) and(3) and (c). When determining which persons are reasonably likely to be exposed as required for § 721.63(a)(1), engineering control measures (
e.g.,
enclosure or confinement of the operation, general and local ventilation) or administrative control measures (
e.g.,
workplace policies and procedures) shall be considered and implemented to prevent exposure, where feasible.
(ii)
Hazard communication.
Requirements as specified in § 721.72(a) through (d), (f), (g)(1), (g)(3)(iii), and (g)(5). For purposes of § 721.72(g)(1), this substance may cause: acute toxicity, skin corrosion, skin irritation, serious eye damage, eye irritation, respiratory sensitization, skin sensitization, genetic toxicity, carcinogenicity, and specific target organ toxicity. Alternative hazard and warning statements that meet the criteria of the Globally Harmonized System and OSHA Hazard Communication Standard may be used.
(iii)
Industrial, commercial, and consumer activities.
Requirements as specified in § 721.80(o). It is a significant new use to manufacture, process, or use the substance in any manner that results in inhalation exposure to the substance.
(iv)
Disposal.
Requirements as specified in § 721.85 (a)(1), (b)(1), and (c)(1).
(v)
Release to water.
Requirements as specified in § 721.90(a)(1), (b)(1), and (c)(1).
(b)
Specific requirements.
The provisions of subpart A of this part apply to this section except as modified by this paragraph (b).
(1)
Recordkeeping.
Recordkeeping requirements as specified in § 721.125(a) through (k) are applicable to manufacturers, importers, and processors of this substance.
(2)
Limitation or revocation of certain notification requirements.
The provisions of § 721.185 apply to this section.
Polyol allyl ether, polymer with alkylene oxides, terpene ether and polyol allyl ether, polymer with alkylene oxides, alkyl ethers (generic).
(a)
Chemical substance and significant new uses subject to reporting.
(1) The chemical substance identified generically as polyol allyl ether, polymer with alkylene oxides, terpene ether and polyol allyl ether, polymer with alkylene oxides, alkyl ethers (PMN P-22-65) is subject to reporting under this section for the significant new uses described in paragraph (a)(2) of this section. The requirements of this section do not apply to quantities of the substance when completely reacted, cured, or incorporated into a polymer matrix.
(2) The significant new uses are:
(i)
Protection in the workplace.
Requirements as specified in § 721.63(a)(1) and (3), and (c). When determining which persons are reasonably likely to be exposed as required for § 721.63(a)(1), engineering control measures (
e.g.,
enclosure or confinement of the operation, general and local ventilation) or administrative control measures (
e.g.,
workplace policies and procedures) shall be considered and implemented to prevent exposure, where feasible.
(ii)
Hazard communication.
Requirements as specified in § 721.72(a) through (d), (f), (g)(1), (g)(3)(iii), and (g)(5). For purposes of § 721.72(g)(1), this substance may cause: acute toxicity, skin corrosion, skin irritation, serious eye damage, eye irritation, respiratory sensitization, skin sensitization, genetic toxicity, carcinogenicity, and specific target organ toxicity. Alternative hazard and warning statements that meet the criteria of the Globally Harmonized System and OSHA Hazard Communication Standard may be used.
(iii)
Industrial, commercial, and consumer activities.
Requirements as specified in § 721.80(o). It is a significant new use to manufacture, process, or use the substance in any manner that results in inhalation exposure to the substance.
(iv)
Disposal.
Requirements as specified in § 721.85 (a)(1), (b)(1), and (c)(1).
(v)
Release to water.
Requirements as specified in § 721.90(a)(1), (b)(1), and (c)(1).
(b)
Specific requirements.
The provisions of subpart A of this part apply to this section except as modified by this paragraph (b).
(1)
Recordkeeping.
Recordkeeping requirements as specified in § 721.125(a) through (k) are applicable to manufacturers, importers, and processors of this substance.
(2)
Limitation or revocation of certain notification requirements.
The provisions of § 721.185 apply to this section.
Polyol allyl ether, polymer with alkylene oxides, terpene ether sulfate, ammonium salt and Polyol allyl ether, polymer with alkylene oxides, alkyl ether sulfate, ammonium salts (generic).
(a)
Chemical substance and significant new uses subject to reporting.
(1) The chemical substance identified generically as polyol allyl ether, polymer with alkylene oxides, terpene ether sulfate, ammonium salt and polyol allyl ether, polymer with alkylene oxides, alkyl ether sulfate, ammonium salts (PMN P-22-66) is subject to reporting under this section for the significant new uses described in paragraph (a)(2) of this section. The requirements of this section do not apply to quantities of the substance when completely reacted, cured, or incorporated into a polymer matrix.
(2) The significant new uses are:
(i)
Protection in the workplace.
Requirements as specified in § 721.63(a)(1) and (3), and (c). When determining which persons are reasonably likely to be exposed as required for § 721.63(a)(1), engineering control measures (
e.g.,
enclosure or confinement of the operation, general and local ventilation) or administrative control measures (
e.g.,
workplace policies and procedures) shall be considered and implemented to prevent exposure, where feasible.
(ii)
Hazard communication.
Requirements as specified in § 721.72(a) through (d), (f), (g)(1), (g)(3)(iii), and (g)(5). For purposes of § 721.72(g)(1), this substance may cause: acute toxicity, skin corrosion, serious eye damage, respiratory sensitization, skin sensitization, genetic toxicity, carcinogenicity, and specific target organ toxicity. Alternative hazard and warning statements that meet the criteria of the Globally Harmonized System and OSHA Hazard Communication Standard may be used.
(iii)
Industrial, commercial, and consumer activities.
Requirements as specified in § 721.80(o). It is a
( printed page 31970)
significant new use to manufacture, process, or use the substance in any manner that results in inhalation exposure to the substance.
(iv)
Disposal.
Requirements as specified in § 721.85 (a)(1), (b)(1), and (c)(1).
(v)
Release to water.
Requirements as specified in § 721.90(a)(1), (b)(1), and (c)(1).
(b)
Specific requirements.
The provisions of subpart A of this part apply to this section except as modified by this paragraph (b).
(1)
Recordkeeping.
Recordkeeping requirements as specified in § 721.125(a) through (k) are applicable to manufacturers, importers, and processors of this substance.
(2)
Limitation or revocation of certain notification requirements.
The provisions of § 721.185 apply to this section.
Polyol allyl ether, polymer with alkylene oxides, terpene ether sulfate, ammonium salt and Polyol allyl ether, polymer with alkylene oxides, alkyl ether sulfate, ammonium salts (generic).
(a)
Chemical substance and significant new uses subject to reporting.
(1) The chemical substance identified generically as polyol allyl ether, polymer with alkylene oxides, terpene ether sulfate, ammonium salt and polyol allyl ether, polymer with alkylene oxides, alkyl ether sulfate, ammonium salts (PMN P-22-67) is subject to reporting under this section for the significant new uses described in paragraph (a)(2) of this section. The requirements of this section do not apply to quantities of the substance when completely reacted, cured, or incorporated into a polymer matrix.
(2) The significant new uses are:
(i)
Protection in the workplace.
Requirements as specified in § 721.63(a)(1), and (3), and (c). When determining which persons are reasonably likely to be exposed as required for § 721.63(a)(1), engineering control measures (
e.g.,
enclosure or confinement of the operation, general and local ventilation) or administrative control measures (
e.g.,
workplace policies and procedures) shall be considered and implemented to prevent exposure, where feasible.
(ii)
Hazard communication.
Requirements as specified in § 721.72(a) through (d), (f), (g)(1), (g)(3)(iii), and (g)(5). For purposes of § 721.72(g)(1), this substance may cause: acute toxicity, skin corrosion, serious eye damage, respiratory sensitization, skin sensitization, genetic toxicity, carcinogenicity, and specific target organ toxicity. Alternative hazard and warning statements that meet the criteria of the Globally Harmonized System and OSHA Hazard Communication Standard may be used.
(iii)
Industrial, commercial, and consumer activities.
Requirements as specified in § 721.80(o). It is a significant new use to manufacture, process, or use the substance in any manner that results in inhalation exposure to the substance.
(iv)
Disposal.
Requirements as specified in § 721.85 (a)(1), (b)(1), and (c)(1).
(v)
Release to water.
Requirements as specified in § 721.90(a)(1), (b)(1), and (c)(1).
(b)
Specific requirements.
The provisions of subpart A of this part apply to this section except as modified by this paragraph (b).
(1)
Recordkeeping.
Recordkeeping requirements as specified in § 721.125(a) through (k) are applicable to manufacturers, importers, and processors of this substance.
(2)
Limitation or revocation of certain notification requirements.
The provisions of § 721.185 apply to this section.
2-Propenoic acid, 2-methyl-, 2-hydroxyethyl ester, reaction products with 2-oxepanone homopolymer 2-[(2-methyl-1-oxo-2-propen-1-yl)oxy]ethyl] ester and phosphorous oxide (P2O5).
(a)
Chemical substance and significant new uses subject to reporting.
(1) The chemical substance identified as 2-propenoic acid, 2-methyl-, 2-hydroxyethyl ester, reaction products with 2-oxepanone homopolymer 2-[(2-methyl-1-oxo-2-propen-1-yl)oxy]ethyl] ester and phosphorous oxide (P2O5) (PMN P-22-153; CASRN 2548699-72-3) is subject to reporting under this section for the significant new uses described in paragraph (a)(2) of this section.
(2) The significant new uses are:
(i)
Protection in the workplace.
Requirements as specified in § 721.63(a)(1), and (3), and (c). When determining which persons are reasonably likely to be exposed as required for § 721.63(a)(1), engineering control measures (
e.g.,
enclosure or confinement of the operation, general and local ventilation) or administrative control measures (
e.g.,
workplace policies and procedures) shall be considered and implemented to prevent exposure, where feasible.
(ii)
Hazard communication.
Requirements as specified in § 721.72(a) through (d), (f), (g)(1), (g)(3)(iii), and (g)(5). For purposes of § 721.72(g)(1), this substance may cause: skin irritation, serious eye damage, respiratory sensitization, skin sensitization, carcinogenicity, genetic toxicity, and specific target organ toxicity. Alternative hazard and warning statements that meet the criteria of the Globally Harmonized System and OSHA Hazard Communication Standard may be used.
(iii)
Industrial, commercial, and consumer activities.
Requirements as specified in § 721.80(o). It is a significant new use to manufacture, process, or use the substance in any manner that results in inhalation exposure to the substance.
(iv)
Release to water.
Requirements as specified in § 721.90(a)(4), (b)(4), and (c)(4) where N=3.
(b)
Specific requirements.
The provisions of subpart A of this part apply to this section except as modified by this paragraph (b).
(1)
Recordkeeping.
Recordkeeping requirements as specified in § 721.125(a) through (i), and (k) are applicable to manufacturers, importers, and processors of this substance.
(2)
Limitation or revocation of certain notification requirements.
The provisions of § 721.185 apply to this section.
(a)
Chemical substance and significant new uses subject to reporting.
(1) The chemical substance identified generically as alkyl acid, 2-hydroxy-, methyl substituted alkyl ester (PMN P-22-165) is subject to reporting under this section for the significant new uses described in paragraph (a)(2) of this section.
(2) The significant new uses are:
(i)
Protection in the workplace.
Requirements as specified in § 721.63(a)(1), (a)(3) through (6), and (c). When determining which persons are reasonably likely to be exposed as required for § 721.63(a)(1) and (4), engineering control measures (
e.g.,
enclosure or confinement of the operation, general and local ventilation) or administrative control measures (
e.g.,
workplace policies and procedures) shall be considered and implemented to prevent exposure, where feasible. For purposes of § 721.63(a)(5), respirators must provide a National Institute for Occupational Safety and Health (NIOSH) assigned protection factor (APF) of at least 1000.
(ii)
Hazard communication.
Requirements as specified in § 721.72(a) through (d), (f), (g)(1), (g)(3)(iii), and (g)(5). For purposes of § 721.72(g)(1), this substance may cause: serious eye damage, carcinogenicity, reproductive toxicity, and specific target organ
( printed page 31971)
toxicity. Alternative hazard and warning statements that meet the criteria of the Globally Harmonized System and OSHA Hazard Communication Standard may be used.
(iii)
Industrial, commercial, and consumer activities.
Requirements as specified in § 721.80(k).
(iv)
Release to water.
Requirements as specified in § 721.90(a)(4), (b)(4), and (c)(4) where N=231.
(b)
Specific requirements.
The provisions of subpart A of this part apply to this section except as modified by this paragraph (b).
(1)
Recordkeeping.
Recordkeeping requirements as specified in § 721.125(a) through (i), and (k) are applicable to manufacturers, importers, and processors of this substance.
(2)
Limitation or revocation of certain notification requirements.
The provisions of § 721.185 apply to this section.
(a)
Chemical substance and significant new uses subject to reporting.
(1) The chemical substance identified generically as cysteine, cyclic alkyl, ethyl ester; alkylthio ketone (PMN P-23-9) is subject to reporting under this section for the significant new uses described in paragraph (a)(2) of this section.
(2) The significant new uses are:
(i)
Protection in the workplace.
Requirements as specified in § 721.63(a)(1), and (3), and (c). When determining which persons are reasonably likely to be exposed as required for § 721.63(a)(1), engineering control measures (
e.g.,
enclosure or confinement of the operation, general and local ventilation) or administrative control measures (
e.g.,
workplace policies and procedures) shall be considered and implemented to prevent exposure, where feasible.
(ii)
Hazard communication.
Requirements as specified in § 721.72(a) through (d), (f), (g)(1), (g)(3)(iii), and (g)(5). For purposes of § 721.72(g)(1), this substance may cause: skin irritation (degradation product), skin sensitization, and specific target organ toxicity. Alternative hazard and warning statements that meet the criteria of the Globally Harmonized System and OSHA Hazard Communication Standard may be used.
(iii)
Industrial, commercial, and consumer activities.
It is a significant new use to manufacture or process the substance in any manner that results in inhalation exposure to the substance. It is a significant new use to process for use or use the substance in a consumer product unless the concentration does not exceed 0.1% by weight in the consumer product.
(iv)
Disposal.
It is a significant new use to land apply the substance, or waste streams containing the substance, to agricultural lands.
(v)
Release to water.
Requirements as specified in § 721.90(a)(1), (b)(1), and (c)(1).
(b)
Specific requirements.
The provisions of subpart A of this part apply to this section except as modified by this paragraph (b).
(1)
Recordkeeping.
Recordkeeping requirements as specified in § 721.125(a) through (k) are applicable to manufacturers, importers, and processors of this substance.
(2)
Limitation or revocation of certain notification requirements.
The provisions of § 721.185 apply to this section.
(a)
Chemical substance and significant new uses subject to reporting.
(1) The chemical substance identified generically as cysteine, cyclic alkyl, ethyl ester; alkylthio ketone (PMN P-23-10) is subject to reporting under this section for the significant new uses described in paragraph (a)(2) of this section.
(2) The significant new uses are:
(i)
Protection in the workplace.
Requirements as specified in § 721.63(a)(1), and (3), and (c). When determining which persons are reasonably likely to be exposed as required for § 721.63(a)(1), engineering control measures (
e.g.,
enclosure or confinement of the operation, general and local ventilation) or administrative control measures (
e.g.,
workplace policies and procedures) shall be considered and implemented to prevent exposure, where feasible.
(ii)
Hazard communication.
Requirements as specified in § 721.72(a) through (d), (f), (g)(1), (g)(3)(iii), and (g)(5). For purposes of § 721.72(g)(1), this substance may cause: acute toxicity (degradation product), skin irritation (degradation product), eye irritation (degradation product), skin sensitization, reproductive toxicity (degradation product), and specific target organ toxicity. Alternative hazard and warning statements that meet the criteria of the Globally Harmonized System and OSHA Hazard Communication Standard may be used.
(iii)
Industrial, commercial, and consumer activities.
It is a significant new use to manufacture or process the substance in any manner that results in inhalation exposure to the substance. It is a significant new use to process for use or use the substance in a consumer product unless the concentration does not exceed 1% by weight in the consumer product.
(iv)
Disposal.
It is a significant new use to land apply the substance, or waste streams containing the substance, to agricultural lands.
(v)
Release to water.
Requirements as specified in § 721.90(a)(1), (b)(1), and (c)(1).
(b)
Specific requirements.
The provisions of subpart A of this part apply to this section except as modified by this paragraph (b).
(1)
Recordkeeping.
Recordkeeping requirements as specified in § 721.125(a) through (k) are applicable to manufacturers, importers, and processors of this substance.
(2)
Limitation or revocation of certain notification requirements.
The provisions of § 721.185 apply to this section.
1,3-Propanediol, polymer with 1,3-diisocyanatomethylbenzene.
(a)
Chemical substance and significant new uses subject to reporting.
(1) The chemical substance identified as 1,3-propanediol, polymer with 1,3-diisocyanatomethylbenzene (PMN P-23-32; CASRN 67517-96-8) is subject to reporting under this section for the significant new uses described in paragraph (a)(2) of this section. The requirements of this section do not apply to quantities of the substance after they have been completely reacted or cured.
(2) The significant new uses are:
(i)
Protection in the workplace.
Requirements as specified in § 721.63(a)(1), and (3), and (c). When determining which persons are reasonably likely to be exposed as required for § 721.63(a)(1), engineering control measures (
e.g.,
enclosure or confinement of the operation, general and local ventilation) or administrative control measures (
e.g.,
workplace policies and procedures) shall be considered and implemented to prevent exposure, where feasible.
(ii)
Hazard communication.
Requirements as specified in § 721.72(a) through (d), (f), (g)(1), and (5). For purposes of § 721.72(g)(1), this substance may cause: acute toxicity, respiratory sensitization, skin sensitization, genetic toxicity, carcinogenicity, reproductive toxicity, and specific target organ toxicity. Alternative hazard and warning statements that meet the criteria of the Globally Harmonized System and OSHA Hazard Communication Standard may be used.
( printed page 31972)
(iii)
Industrial, commercial, and consumer activities.
Requirements as specified in § 721.80(o). It is a significant new use to manufacture, process, or use the substance in any manner that results in inhalation exposure to the substance.
(b)
Specific requirements.
The provisions of subpart A of this part apply to this section except as modified by this paragraph (b).
(1)
Recordkeeping.
Recordkeeping requirements as specified in § 721.125(a) through (i) are applicable to manufacturers, importers, and processors of this substance.
(2)
Limitation or revocation of certain notification requirements.
The provisions of § 721.185 apply to this section.
Glycerides from fermentation of genetically modified microorganism, ethoxylated, reaction products with ethanol, polycyclic isocyanate (generic).
(a)
Chemical substance and significant new uses subject to reporting.
(1) The chemical substance identified generically as glycerides from fermentation of genetically modified microorganism, ethoxylated, reaction products with ethanol, polycyclic isocyanate (PMN P-23-118) is subject to reporting under this section for the significant new uses described in paragraph (a)(2) of this section. The requirements of this section do not apply to quantities of the substance after they have been completely reacted or cured (
i.e.,
the substance has been reacted or cured to the extent that no release of the substance can be detected).
(2) The significant new uses are:
(i)
Protection in the workplace.
Requirements as specified in § 721.63(a)(1), and (3), and (c). When determining which persons are reasonably likely to be exposed as required for § 721.63(a)(1), engineering control measures (
e.g.,
enclosure or confinement of the operation, general and local ventilation) or administrative control measures (
e.g.,
workplace policies and procedures) shall be considered and implemented to prevent exposure, where feasible.
(ii)
Hazard communication.
Requirements as specified in § 721.72(a) through (d), (f), (g)(1), and (5). For purposes of § 721.72(g)(1), this substance may cause: eye irritation, respiratory sensitization, skin irritation, skin sensitization, and specific target organ toxicity. Alternative hazard and warning statements that meet the criteria of the Globally Harmonized System and OSHA Hazard Communication Standard may be used.
(iii)
Industrial, commercial, and consumer activities.
Requirements as specified in § 721.80(o). It is a significant new use to manufacture, process, or use the substance in any manner that results in inhalation exposure to the substance. It is a significant new use to manufacture the substance in a formulation unless the percentage of the confidential unreacted substance listed in the Order does not exceed the confidential percentage by weight listed in the Order.
(iv)
Disposal.
It is a significant new use to dispose of the substance in any manner that results in inhalation exposure to the substance. It is a significant new use to dispose of the substance other than by hazardous waste incineration and the disposal must be at a facility that is in compliance with RCRA subtitle C.
(b)
Specific requirements.
The provisions of subpart A of this part apply to this section except as modified by this paragraph (b).
(1)
Recordkeeping.
Recordkeeping requirements as specified in § 721.125(a) through (j) are applicable to manufacturers, importers, and processors of this substance.
(2)
Limitation or revocation of certain notification requirements.
The provisions of § 721.185 apply to this section.
(a)
Chemical substance and significant new uses subject to reporting.
(1) The chemical substance identified generically as alkenal, 9-(acetyloxy)-, (E)- (PMN P-23-142; Accession No. 302751) is subject to reporting under this section for the significant new uses described in paragraph (a)(2) of this section.
(2) The significant new uses are:
(i)
Protection in the workplace.
Requirements as specified in § 721.63(a)(1), (a)(3) through (6), and (c). When determining which persons are reasonably likely to be exposed as required for § 721.63(a)(1) and (4), engineering control measures (
e.g.,
enclosure or confinement of the operation, general and local ventilation) or administrative control measures (
e.g.,
workplace policies and procedures) shall be considered and implemented to prevent exposure, where feasible. For purposes of § 721.63(a)(5), respirators must provide a National Institute for Occupational Safety and Health (NIOSH) assigned protection factor (APF) of at least 50.
(ii)
Hazard communication.
Requirements as specified in § 721.72(a) through (d), (f), (g)(1), (g)(3)(iii), and (g)(5). For purposes of § 721.72(g)(1), this substance may cause: skin irritation, respiratory sensitization, skin sensitization, reproductive toxicity, and specific target organ toxicity. Alternative hazard and warning statements that meet the criteria of the Globally Harmonized System and OSHA Hazard Communication Standard may be used.
(iii)
Industrial, commercial, and consumer activities.
Requirements as specified in § 721.80(o).
(iv)
Disposal.
Requirements as specified in § 721.85(a)(1), (b)(1), and (c)(1).
(v)
Release to water.
Requirements as specified in § 721.90(a)(1), (b)(1), and (c)(1).
(b)
Specific requirements.
The provisions of subpart A of this part apply to this section except as modified by this paragraph (b).
(1)
Recordkeeping.
Recordkeeping requirements as specified in § 721.125(a) through (k) are applicable to manufacturers, importers, and processors of this substance.
(2)
Limitation or revocation of certain notification requirements.
The provisions of § 721.185 apply to this section.
Cellulose, alkoxyalkyl ether, alkali metal salt (generic).
(a)
Chemical substance and significant new uses subject to reporting.
(1) The chemical substance identified generically as cellulose, alkoxyalkyl ether, alkali metal salt (PMN P-23-173; Accession No. 303061) is subject to reporting under this section for the significant new uses described in paragraph (a)(2) of this section. The requirements of this section do not apply to quantities of the substance after they have been incorporated into an article as defined at 40 CFR 720.3 or when the substance is embedded in or cured in a matrix.
(2) The significant new uses are:
(i)
Protection in the workplace.
Requirements as specified in § 721.63(a)(1), (a)(3) through (6), and (c). When determining which persons are reasonably likely to be exposed as required for § 721.63(a)(1) and (a)(4), engineering control measures (
e.g.,
enclosure or confinement of the operation, general and local ventilation) or administrative control measures (
e.g.,
workplace policies and procedures) shall be considered and implemented to prevent exposure, where feasible. For purposes of § 721.63(a)(5), respirators must provide a National Institute for Occupational Safety and Health (NIOSH) assigned protection factor (APF) of at least 10.
( printed page 31973)
(ii)
Hazard communication.
Requirements as specified in § 721.72(a) through (d), (f), (g)(1), (g)(3)(iii), and (g)(5). For purposes of § 721.72(g)(1), this substance may cause: specific target organ toxicity and reproductive toxicity. Alternative hazard and warning statements that meet the criteria of the Globally Harmonized System and OSHA Hazard Communication Standard may be used.
(iii)
Industrial, commercial, and consumer activities.
Requirements as specified in § 721.80(k).
(iv)
Release to water.
Requirements as specified in § 721.90(a)(4), (b)(4), and (c)(4) where N=120.
(b)
Specific requirements.
The provisions of subpart A of this part apply to this section except as modified by this paragraph (b).
(1)
Recordkeeping.
Recordkeeping requirements as specified in § 721.125(a) through (i), and (k) are applicable to manufacturers, importers, and processors of this substance.
(2)
Limitation or revocation of certain notification requirements.
The provisions of § 721.185 apply to this section.
(a)
Chemical substance and significant new uses subject to reporting.
(1) The chemical substance identified as L-Aspartic acid, N-benzoyl-, sodium salt (1:2) (PMN P-24-4; CASRN 2092399-70-5) is subject to reporting under this section for the significant new uses described in paragraph (a)(2) of this section. The requirements of this section do not apply to quantities of the substance after they have been completely reacted or cured (
i.e.,
the substance has been reacted or cured to the extent that no release of the substance can be detected).
(2) The significant new uses are:
(i)
Protection in the workplace.
Requirements as specified in § 721.63(a)(1), (a)(3) through (6), and (c). When determining which persons are reasonably likely to be exposed as required for § 721.63(a)(1) and (4), engineering control measures (
e.g.,
enclosure or confinement of the operation, general and local ventilation) or administrative control measures (
e.g.,
workplace policies and procedures) shall be considered and implemented to prevent exposure, where feasible. For purposes of § 721.63(a)(5), respirators must provide a National Institute for Occupational Safety and Health (NIOSH) assigned protection factor (APF) of at least 10.
(ii)
Hazard communication.
Requirements as specified in § 721.72(a) through (d), (f), (g)(1), and (5). For purposes of § 721.72(g)(1), this substance may cause: eye irritation and specific target organ toxicity. Alternative hazard and warning statements that meet the criteria of the Globally Harmonized System and OSHA Hazard Communication Standard may be used.
(iii)
Industrial, commercial, and consumer activities.
Requirements as specified in § 721.80(k) and (t).
(b)
Specific requirements.
The provisions of subpart A of this part apply to this section except as modified by this paragraph (b).
(1)
Recordkeeping.
Recordkeeping requirements as specified in § 721.125(a) through (i) are applicable to manufacturers, importers, and processors of this substance.
(2)
Limitation or revocation of certain notification requirements.
The provisions of § 721.185 apply to this section.
(a)
Chemical substance and significant new uses subject to reporting.
(1) The chemical substance identified generically as alkylated succinimide (PMN P-24-79; Accession No. 303301) is subject to reporting under this section for the significant new uses described in paragraph (a)(2) of this section.
(2) The significant new uses are:
(i)
Protection in the workplace.
Requirements as specified in § 721.63(a)(1) and (3), and (c). When determining which persons are reasonably likely to be exposed as required for § 721.63(a)(1), engineering control measures (
e.g.,
enclosure or confinement of the operation, general and local ventilation) or administrative control measures (
e.g.,
workplace policies and procedures) shall be considered and implemented to prevent exposure, where feasible.
(ii)
Hazard communication.
Requirements as specified in § 721.72(a) through (d), (f), (g)(1), (g)(3)(iii), and (g)(5). For purposes of § 721.72(g)(1), this substance may cause: specific target organ toxicity. Alternative hazard and warning statements that meet the criteria of the Globally Harmonized System and OSHA Hazard Communication Standard may be used.
(iii) Industrial, commercial, and consumer activities. Requirements as specified in § 721.80(k). It is a significant new use to manufacture or process the substance in any manner that results in inhalation exposure to the substance.
(iv)
Disposal.
It is a significant new use to dispose of the substance in any manner that results in inhalation exposure to the substance. It is a significant new use to dispose of the substance, or waste streams containing the substance, other than by hazardous waste incineration in compliance with RCRA, including RCRA subtitle C.
(v)
Release to water.
Requirements as specified in § 721.90(a)(1), (b)(1), and (c)(1).
(b)
Specific requirements.
The provisions of subpart A of this part apply to this section except as modified by this paragraph (b).
(1)
Recordkeeping.
Recordkeeping requirements as specified in § 721.125(a) through (k) are applicable to manufacturers, importers, and processors of this substance.
(2)
Limitation or revocation of certain notification requirements.
The provisions of § 721.185 apply to this section.
(a)
Chemical substance and significant new uses subject to reporting.
(1) The chemical substance identified as 2-propenoic acid, 3-bromo-2,2-bis(bromomethyl)propyl ester (PMN P-24-82; CASRN 3217-37-6) is subject to reporting under this section for the significant new uses described in paragraph (a)(2) of this section. The requirements of this section do not apply to quantities of the substances when completely reacted or cured (
i.e.,
the substance has been reacted or cured to the extent that no release of the substance can be detected).
(2) The significant new uses are:
(i)
Protection in the workplace.
Requirements as specified in § 721.63(a)(1) and (3), and (c). When determining which persons are reasonably likely to be exposed as required for § 721.63(a)(1), engineering control measures (
e.g.,
enclosure or confinement of the operation, general and local ventilation) or administrative control measures (
e.g.,
workplace policies and procedures) shall be considered and implemented to prevent exposure, where feasible.
(ii)
Hazard communication.
Requirements as specified in § 721.72(a) through (d), (f), (g)(1), (g)(3)(iii), and (g)(5). For purposes of § 721.72(g)(1), this substance may cause: acute toxicity, respiratory sensitization, skin corrosion, skin sensitization, serious eye damage, genetic toxicity, carcinogenicity, reproductive toxicity, and specific target organ toxicity. Alternative hazard and warning statements that meet the criteria of the Globally Harmonized System and OSHA Hazard Communication Standard may be used.
( printed page 31974)
(iii)
Industrial, commercial, and consumer activities.
Requirements as specified in § 721.80(o). It is a significant new use to manufacture the substance other than by import into the United States in ink cartridges (
i.e.,
no domestic manufacture). It is a significant new use to process or use the substance in any manner that results in inhalation exposure to the substance.
(iv)
Disposal.
It is a significant new use to dispose of the substance, or cartridges or waste steams containing the substance, other than by hazardous waste incineration in compliance with RCRA. It is a significant new use to dispose of the substance in any manner that results in inhalation exposure to the substance.
(v)
Release to water.
Requirements as specified in § 721.90(a)(1), (b)(1), and (c)(1).
(b)
Specific requirements.
The provisions of subpart A of this part apply to this section except as modified by this paragraph (b).
(1)
Recordkeeping.
Recordkeeping requirements as specified in § 721.125(a) through (k) are applicable to manufacturers, importers, and processors of this substance.
(2)
Limitation or revocation of certain notification requirements.
The provisions of § 721.185 apply to this section.
(a)
Chemical substance and significant new uses subject to reporting.
(1) The chemical substance identified as siloxanes and silicones, di-Me, 3-[[[[4-[(4-isocyanantocyclohexyl)methyl cyclohexyl]amino]carbonyl]oxy] propyl group-terminated (PMN P-24-85; CASRN 1411848-76-4) is subject to reporting under this section for the significant new uses described in paragraph (a)(2) of this section. The requirements of this section do not apply to quantities of the substance after they have been completely reacted or cured (
i.e.,
the substance has been reacted or cured to the extent that no release of the substance can be detected).
(2) The significant new uses are:
(i)
Protection in the workplace.
Requirements as specified in § 721.63(a)(1) and (3), and (c). When determining which persons are reasonably likely to be exposed as required for § 721.63(a)(1), engineering control measures (
e.g.,
enclosure or confinement of the operation, general and local ventilation) or administrative control measures (
e.g.,
workplace policies and procedures) shall be considered and implemented to prevent exposure, where feasible.
(ii)
Hazard communication.
Requirements as specified in § 721.72(a) through (d), (f), (g)(1), and (5). For purposes of § 721.72(g)(1), this substance may cause: acute toxicity, eye irritation, respiratory sensitization, skin irritation, skin sensitization, and specific target organ toxicity. Alternative hazard and warning statements that meet the criteria of the Globally Harmonized System and OSHA Hazard Communication Standard may be used.
(iii)
Industrial, commercial, and consumer activities.
Requirements as specified in § 721.80(o). It is a significant new use to manufacture, process, or use the substance in any manner that results in inhalation exposure to the substance.
(b)
Specific requirements.
The provisions of subpart A of this part apply to this section except as modified by this paragraph (b).
(1)
Recordkeeping.
Recordkeeping requirements as specified in § 721.125(a) through (i) are applicable to manufacturers, importers, and processors of this substance.
(2)
Limitation or revocation of certain notification requirements.
The provisions of § 721.185 apply to this section.
Alkanediacid polymer with alkanediol, polybutylene glycol and 1,1′-methylenebis[4-isocyanatobenzene] (generic).
(a)
Chemical substance and significant new uses subject to reporting.
(1) The chemical substance identified generically as alkanediacid polymer with alkanediol, polybutylene glycol and 1,1′-methylenebis[4-isocyanatobenzene] (PMN P-24-102; Accession No. 303641) is subject to reporting under this section for the significant new uses described in paragraph (a)(2) of this section. The requirements of this section do not apply to quantities of the substance after they have been completely reacted or cured (
i.e.,
the substance has been reacted or cured to the extent that no release of the substance can be detected).
(2) The significant new uses are:
(i)
Protection in the workplace.
Requirements as specified in § 721.63(a)(1) and (3), and (c). When determining which persons are reasonably likely to be exposed as required for § 721.63(a)(1), engineering control measures (
e.g.,
enclosure or confinement of the operation, general and local ventilation) or administrative control measures (
e.g.,
workplace policies and procedures) shall be considered and implemented to prevent exposure, where feasible.
(ii)
Hazard communication.
Requirements as specified in § 721.72(a) through (d), (f), (g)(1), and (5). For purposes of § 721.72(g)(1), this substance may cause: skin irritation, eye irritation, respiratory sensitization, skin sensitization, and specific target organ toxicity. Alternative hazard and warning statements that meet the criteria of the Globally Harmonized System and OSHA Hazard Communication Standard may be used.
(iii)
Industrial, commercial, and consumer activities.
Requirements as specified in § 721.80(o). It is a significant new use to manufacture, process, or use the substance in any manner that results in inhalation exposure to the substance.
(b)
Specific requirements.
The provisions of subpart A of this part apply to this section except as modified by this paragraph (b).
(1)
Recordkeeping.
Recordkeeping requirements as specified in § 721.125(a) through (i) are applicable to manufacturers, importers, and processors of this substance.
(2)
Limitation or revocation of certain notification requirements.
The provisions of § 721.185 apply to this section.
Alkanediacid polymer with alkanediol, polybutylene glycol and 1,1′-methylenebis[isocyanatobenzene] (generic).
(a)
Chemical substance and significant new uses subject to reporting.
(1) The chemical substance identified generically as alkanediacid polymer with alkanediol, polybutylene glycol and 1,1′-methylenebis [isocyanatobenzene] (PMN P-24-103; Accession No. 303652) is subject to reporting under this section for the significant new uses described in paragraph (a)(2) of this section. The requirements of this section do not apply to quantities of the substance after they have been completely reacted or cured (
i.e.,
the substance has been reacted or cured to the extent that no release of the substance can be detected).
(2) The significant new uses are:
(i)
Protection in the workplace.
Requirements as specified in § 721.63(a)(1) and (3), and (c). When determining which persons are reasonably likely to be exposed as required for § 721.63(a)(1), engineering control measures (
e.g.,
enclosure or confinement of the operation, general and local ventilation) or administrative
( printed page 31975)
control measures (
e.g.,
workplace policies and procedures) shall be considered and implemented to prevent exposure, where feasible.
(ii)
Hazard communication.
Requirements as specified in § 721.72(a) through (d), (f), (g)(1), and (5). For purposes of § 721.72(g)(1), this substance may cause: skin irritation, eye irritation, respiratory sensitization, skin sensitization, and specific target organ toxicity. Alternative hazard and warning statements that meet the criteria of the Globally Harmonized System and OSHA Hazard Communication Standard may be used.
(iii)
Industrial, commercial, and consumer activities.
Requirements as specified in § 721.80(o). It is a significant new use to manufacture, process, or use the substance in any manner that results in inhalation exposure to the substance.
(b)
Specific requirements.
The provisions of subpart A of this part apply to this section except as modified by this paragraph (b).
(1)
Recordkeeping.
Recordkeeping requirements as specified in § 721.125(a) through (i) are applicable to manufacturers, importers, and processors of this substance.
(2)
Limitation or revocation of certain notification requirements.
The provisions of § 721.185 apply to this section.
(a)
Chemical substance and significant new uses subject to reporting.
(1) The chemical substance identified generically as alkanoic acid, mercapto-, ((((mercapto-oxoalkoxy)-(mercapto-oxoalkoxy)alkyl)(alkoxy)alkyl)-((mercapto-oxoalkoxy)(alkyl)-(alkanediyl ester (PMN P-24-129) is subject to reporting under this section for the significant new uses described in paragraph (a)(2) of this section. The requirements of this section do not apply to quantities of the substance after they have been completely reacted or cured (
i.e.,
the substance has been reacted or cured to the extent that no release of the substance can be detected).
(2) The significant new uses are:
(i)
Protection in the workplace.
Requirements as specified in § 721.63(a)(1) and (3), and (c). When determining which persons are reasonably likely to be exposed as required for § 721.63(a)(1), engineering control measures (
e.g.,
enclosure or confinement of the operation, general and local ventilation) or administrative control measures (
e.g.,
workplace policies and procedures) shall be considered and implemented to prevent exposure, where feasible.
(ii)
Hazard communication.
Requirements as specified in § 721.72(a) through (d), (f), (g)(1), (g)(3)(iii), and (g)(5). For purposes of § 721.72(g)(1), this substance may cause: skin sensitization, acute toxicity, respiratory sensitization, reproductive toxicity, and specific target organ toxicity. Alternative hazard and warning statements that meet the criteria of the Globally Harmonized System and OSHA Hazard Communication Standard may be used.
(iii)
Industrial, commercial, and consumer activities.
Requirements as specified in § 721.80(o). It is a significant new use to manufacture, process, or use the substance in any manner that results in inhalation exposure to the substance.
(iv) Release to water. Requirements as specified in § 721.90(a)(4), (b)(4), and (c)(4) where N=1.6.
(b)
Specific requirements.
The provisions of subpart A of this part apply to this section except as modified by this paragraph (b).
(1)
Recordkeeping.
Recordkeeping requirements as specified in § 721.125(a) through (i), and (k) are applicable to manufacturers, importers, and processors of this substance.
(2)
Limitation or revocation of certain notification requirements.
The provisions of § 721.185 apply to this section.
Sulfonium, triphenyl-, salt with fluorosulfoalkyl-fluoroalkyl substituted-heterotricycloalkane-carboxylate (1:1) (generic).
(a)
Chemical substance and significant new uses subject to reporting.
(1) The chemical substance identified generically as sulfonium, triphenyl-, salt with fluorosulfoalkyl-fluoroalkyl substituted-heterotricycloalkane-carboxylate (1:1) (PMN P-24-185) is subject to reporting under this section for the significant new uses described in paragraph (a)(2) of this section. The requirements of this section do not apply to quantities of the substance after they have been completely reacted or adhered (during photolithographic processes) onto a semiconductor wafer surface or similar manufactured article used in the production of semiconductor technologies.
(2) The significant new uses are:
(i)
Protection in the workplace.
Requirements as specified in § 721.63(a)(1), (a)(2)(i) and (a)(2)(iii), (a)(3), and (c). When determining which persons are reasonably likely to be exposed as required for § 721.63(a)(1), engineering control measures (
e.g.,
enclosure or confinement of the operation, general and local ventilation) or administrative control measures (
e.g.,
workplace policies and procedures) shall be considered and implemented to prevent exposure, where feasible.
(ii)
Hazard communication.
Requirements as specified in § 721.72(a) through (f), (g)(1), (g)(2)(i) through (iii) and (g)(2)(v), (g)(3)(i) and (ii), and (g)(5). For purposes of § 721.72(e), the concentration is set at 1.0%. For purposes of § 721.72(g)(1), this substance may cause: acute toxicity, genetic toxicity, skin irritation, skin sensitization, serious eye damage, and specific target organ toxicity. Alternative hazard and warning statements that meet the criteria of the Globally Harmonized System and OSHA Hazard Communication Standard may be used.
(iii)
Industrial, commercial, and consumer activities.
Requirements as specified in § 721.80(f), (k), and (t). It is a significant new use to import the substance other than in solution, unless in sealed containers weighing 5 kilograms or less. It is a significant new use to process the substance in any way that generates dust, mist, or aerosol in a non-enclosed process. It is a significant new use to manufacture the substance longer than 18 months.
(b)
Specific requirements.
The provisions of subpart A of this part apply to this section except as modified by this paragraph (b).
(1)
Recordkeeping.
Recordkeeping requirements as specified in § 721.125(a) through (i) are applicable to manufacturers, importers, and processors of this substance.
(2)
Limitation or revocation of certain notification requirements.
The provisions of § 721.185 apply to this section.
(a)
Chemical substance and significant new uses subject to reporting.
(1) The chemical substance identified generically as heteroonium, tri(substitutedaromatichydrocarbon)-, nitrate (1:1) (PMN P-25-28) is subject to reporting under this section for the significant new uses described in paragraph (a)(2) of this section. The requirements of this section do not apply to quantities of the substance after they have been completely reacted or adhered (during photolithographic processes) onto a semiconductor wafer surface or similar manufactured article
( printed page 31976)
used in the production of semiconductor technologies.
(2) The significant new uses are:
(i)
Protection in the workplace.
Requirements as specified in § 721.63(a)(1), (a)(2)(i) and (a)(2)(iii), (a)(3), and (c). When determining which persons are reasonably likely to be exposed as required for § 721.63(a)(1), engineering control measures (
e.g.,
enclosure or confinement of the operation, general and local ventilation) or administrative control measures (
e.g.,
workplace policies and procedures) shall be considered and implemented to prevent exposure, where feasible.
(ii)
Hazard communication.
Requirements as specified in § 721.72(a) through (f), (g)(1), (g)(2)(i) through (iii) and(g)(2) (v), (g)(3)(i) and (ii), and (g)(5). For purposes of § 721.72(e), the concentration is set at 0.1%. For purposes of § 721.72(g)(1), this substance may cause: acute toxicity, carcinogenicity, reproductive toxicity, genetic toxicity, skin irritation, skin sensitization, serious eye damage, and specific target organ toxicity. Alternative hazard and warning statements that meet the criteria of the Globally Harmonized System and OSHA Hazard Communication Standard may be used.
(iii)
Industrial, commercial, and consumer activities.
Requirements as specified in § 721.80(f), (k), and (t). It is a significant new use to import the substance other than in solution, unless in sealed containers weighing 5 kilograms or less. It is a significant new use to process the substance in any way that generates dust, mist, or aerosol in a non-enclosed process. It is a significant new use to manufacture the substance longer than 18 months.
(b)
Specific requirements.
The provisions of subpart A of this part apply to this section except as modified by this paragraph (b).
(1)
Recordkeeping.
Recordkeeping requirements as specified in § 721.125(a) through (i) are applicable to manufacturers, importers, and processors of this substance.
(2)
Limitation or revocation of certain notification requirements.
The provisions of § 721.185 apply to this section.
(a)
Chemical substance and significant new uses subject to reporting.
(1) The chemical substance identified generically as alkyl transition metal alkoxide (PMN P-24-187) is subject to reporting under this section for the significant new uses described in paragraph (a)(2) of this section. The requirements of this section do not apply to quantities of the substance after they have been destroyed.
(2) The significant new uses are:
(i)
Protection in the workplace.
Requirements as specified in § 721.63(a)(1) and (3), and (c). When determining which persons are reasonably likely to be exposed as required for § 721.63(a)(1), engineering control measures (
e.g.,
enclosure or confinement of the operation, general and local ventilation) or administrative control measures (
e.g.,
workplace policies and procedures) shall be considered and implemented to prevent exposure, where feasible.
(ii)
Hazard communication.
Requirements as specified in § 721.72(a) through (d), (f), (g)(1), (g)(3)(iii), and (g)(5). For purposes of § 721.72(g)(1), this substance may cause: skin corrosion, serious eye damage, reproductive toxicity, and specific target organ toxicity. Alternative hazard and warning statements that meet the criteria of the Globally Harmonized System and OSHA Hazard Communication Standard may be used.
(iii)
Industrial, commercial, and consumer activities.
Requirements as specified in § 721.80(k). It is a significant new use to manufacture, process, or use the substance in any manner that generates a vapor, mist, dust, or aerosol outside of a fully enclosed system containing the substance.
(iv)
Release to water.
Requirements as specified in § 721.90(a)(1), (b)(1), and (c)(1).
(b)
Specific requirements.
The provisions of subpart A of this part apply to this section except as modified by this paragraph (b).
(1)
Recordkeeping.
Recordkeeping requirements as specified in § 721.125(a) through (i), and (k) are applicable to manufacturers, importers, and processors of this substance.
(2)
Limitation or revocation of certain notification requirements.
The provisions of § 721.185 apply to this section.
(a)
Chemical substance and significant new uses subject to reporting.
(1) The chemical substance identified generically as silsesquioxanes, alkyl Ph alkoxy(halosubstitutedphenyl), polymers with silicic acid (H4SiO4) tetra-Me ester, hydroxy-terminated (PMN P-24-189) is subject to reporting under this section for the significant new uses described in paragraph (a)(2) of this section.
(2) The significant new uses are:
(i)
Hazard communication.
Requirements as specified in § 721.72(a) through (d), (f), (g)(1), and (5). For purposes of § 721.72(g)(1), this substance may cause: acute toxicity and specific target organ toxicity. Alternative hazard and warning statements that meet the criteria of the Globally Harmonized System and OSHA Hazard Communication Standard may be used.
(ii)
Industrial, commercial, and consumer activities.
Requirements as specified in § 721.80(k). It is a significant new use to manufacture, process, or use the substance in any manner that results in inhalation exposure to the substance.
(b)
Specific requirements.
The provisions of subpart A of this part apply to this section except as modified by this paragraph (b).
(1)
Recordkeeping.
Recordkeeping requirements as specified in § 721.125(a) through (c) and (f) through (i) are applicable to manufacturers, importers, and processors of this substance.
(2)
Limitation or revocation of certain notification requirements.
The provisions of § 721.185 apply to this section.
(a)
Chemical substance and significant new uses subject to reporting.
(1) The chemical substance identified generically as phenoxathiinium, 10-phenyl-, tricycloalkylcarbomonocyclesulfonate (1:1) (PMN P-25-3) is subject to reporting under this section for the significant new uses described in paragraph (a)(2) of this section. The requirements of this section do not apply to quantities of the substance after they have been completely reacted or adhered (during photolithographic processes) onto a semiconductor wafer surface or similar manufactured article used in the production of semiconductor technologies.
(2) The significant new uses are:
(i)
Protection in the workplace.
Requirements as specified in § 721.63(a)(1), (a)(2)(i) and (a)(2)(iii), (a)(3), and (c). When determining which persons are reasonably likely to be exposed as required for § 721.63(a)(1), engineering control measures (
e.g.,
enclosure or confinement of the operation, general and local ventilation) or administrative control measures (
e.g.,
workplace policies and procedures) shall be considered and implemented to prevent exposure, where feasible.
( printed page 31977)
(ii)
Hazard communication.
Requirements as specified in § 721.72(a) through (f), (g)(1), (g)(2)(i) through (iii) and (g)(2)(v), (g)(3)(i) and (ii), and (g)(5). For purposes of § 721.72(e), the concentration is set at 1.0%. For purposes of § 721.72(g)(1), this substance may cause: acute toxicity, skin irritation, serious eye damage, skin sensitization, genetic toxicity, and specific target organ toxicity. Alternative hazard and warning statements that meet the criteria of the Globally Harmonized System and OSHA Hazard Communication Standard may be used.
(iii)
Industrial, commercial, and consumer activities.
Requirements as specified in § 721.80(f), (k), and (t). It is a significant new use to import the substance other than in solution, unless in sealed containers weighing 5 kilograms or less. It is a significant new use to process the substance in any way that generates dust, mist, or aerosol in a non-enclosed process. It is a significant new use to manufacture the substance longer than 9 months.
(b)
Specific requirements.
The provisions of subpart A of this part apply to this section except as modified by this paragraph (b).
(1)
Recordkeeping.
Recordkeeping requirements as specified in § 721.125(a) through (i) are applicable to manufacturers, importers, and processors of this substance.
(2)
Limitation or revocation of certain notification requirements.
The provisions of § 721.185 apply to this section.
(a)
Chemical substance and significant new uses subject to reporting.
(1) The chemical substance identified generically as sulfonium, triphenyl-, heteropolyclyclecarboxylate (1:1) (PMN P-25-4) is subject to reporting under this section for the significant new uses described in paragraph (a)(2) of this section. The requirements of this section do not apply to quantities of the substance after they have been completely reacted or adhered (during photolithographic processes) onto a semiconductor wafer surface or similar manufactured article used in the production of semiconductor technologies.
(2) The significant new uses are:
(i)
Protection in the workplace.
Requirements as specified in § 721.63(a)(1), (a)(2)(i) and (a)(2)(iii), (a)(3), and (c). When determining which persons are reasonably likely to be exposed as required for § 721.63(a)(1), engineering control measures (
e.g.,
enclosure or confinement of the operation, general and local ventilation) or administrative control measures (
e.g.,
workplace policies and procedures) shall be considered and implemented to prevent exposure, where feasible.
(ii)
Hazard communication.
Requirements as specified in § 721.72(a) through (f), (g)(1), (g)(2)(i) through (iii) and (g)(2)(v), (g)(3)(i) and (ii), and (g)(5). For purposes of § 721.72(e), the concentration is set at 1.0%. For purposes of § 721.72(g)(1), this substance may cause: acute toxicity, skin irritation, serious eye damage, skin sensitization, genetic toxicity, and specific target organ toxicity. Alternative hazard and warning statements that meet the criteria of the Globally Harmonized System and OSHA Hazard Communication Standard may be used.
(iii)
Industrial, commercial, and consumer activities.
Requirements as specified in § 721.80(f), (k), and (t). It is a significant new use to import the substance other than in solution, unless in sealed containers weighing 5 kilograms or less. It is a significant new use to process the substance in any way that generates dust, mist, or aerosol in a non-enclosed process. It is a significant new use to manufacture the substance longer than 9 months.
(b)
Specific requirements.
The provisions of subpart A of this part apply to this section except as modified by this paragraph (b).
(1)
Recordkeeping.
Recordkeeping requirements as specified in § 721.125(a) through (i) are applicable to manufacturers, importers, and processors of this substance.
(2)
Limitation or revocation of certain notification requirements.
The provisions of § 721.185 apply to this section.
Trihaloaromatic iodonium dicyclo salt with polyhaloalkyl carbomonocycle hetero-acid (generic).
(a)
Chemical substance and significant new uses subject to reporting.
(1) The chemical substance identified generically as trihaloaromatic iodonium dicyclo salt with polyhaloalkyl carbomonocycle hetero-acid (PMN P-25-16; Accession No. 303389) is subject to reporting under this section for the significant new uses described in paragraph (a)(2) of this section. The requirements of this section do not apply to quantities of the substance after they have been completely reacted or adhered (during photolithographic processes) onto a semiconductor wafer surface or similar manufactured article used in the production of semiconductor technologies.
(2) The significant new uses are:
(i)
Protection in the workplace.
Requirements as specified in § 721.63(a)(1), (a)(2)(i) and (a)(2)(iii), (a)(3), and (c). When determining which persons are reasonably likely to be exposed as required for § 721.63(a)(1), engineering control measures (
e.g.,
enclosure or confinement of the operation, general and local ventilation) or administrative control measures (
e.g.,
workplace policies and procedures) shall be considered and implemented to prevent exposure, where feasible.
(ii)
Hazard communication.
Requirements as specified in § 721.72(a) through (f), (g)(1), (g)(2)(i) through (iii) and (g)(2)(v), (g)(3)(i) and (ii), and (g)(5). For purposes of § 721.72(e), the concentration is set at 0.1%. For purposes of § 721.72(g)(1), this substance may cause: acute toxicity, skin irritation, skin sensitization, genetic toxicity, reproductive toxicity, specific target organ toxicity, and carcinogenicity. Alternative hazard and warning statements that meet the criteria of the Globally Harmonized System and OSHA Hazard Communication Standard may be used.
(iii)
Industrial, commercial, and consumer activities.
Requirements as specified in § 721.80(f), (k), and (t). It is a significant new use to import the substance other than in solution, unless in sealed containers weighing 5 kilograms or less. It is a significant new use to process the substance in any way that generates dust, mist, or aerosol in a non-enclosed process. It is a significant new use to manufacture the substance longer than 18 months.
(b) Specific requirements. The provisions of subpart A of this part apply to this section except as modified by this paragraph (b).
(1)
Recordkeeping.
Recordkeeping requirements as specified in § 721.125(a) through (i) are applicable to manufacturers, importers, and processors of this substance.
(2)
Limitation or revocation of certain notification requirements.
The provisions of § 721.185 apply to this section.
Sulfonium, triphenyl-, salt with heterosubstituteddifluorosubstitutedalkylsubstitutedalkyltrihalosubstitutedcarbomonocycle carboxylate (1:1) (generic).
(a)
Chemical substance and significant new uses subject to reporting.
(1) The chemical substance identified generically as sulfonium, triphenyl-, salt with heterosubstituteddifluorosubstitutedalkyl substitutedalkyl trihalosubstitutedcarbomonocycle carboxylate (1:1) (PMN P-25-20) is subject to reporting under this section for the
( printed page 31978)
significant new uses described in paragraph (a)(2) of this section. The requirements of this section do not apply to quantities of the substance after they have been completely reacted or adhered (during photolithographic processes) onto a semiconductor wafer surface or similar manufactured article used in the production of semiconductor technologies.
(2) The significant new uses are:
(i)
Protection in the workplace.
Requirements as specified in § 721.63(a)(1), (a)(2)(i) and (a)(2)(iii), (a)(3), and (c). When determining which persons are reasonably likely to be exposed as required for § 721.63(a)(1), engineering control measures (
e.g.,
enclosure or confinement of the operation, general and local ventilation) or administrative control measures (
e.g.,
workplace policies and procedures) shall be considered and implemented to prevent exposure, where feasible.
(ii)
Hazard communication.
Requirements as specified in § 721.72(a) through (f), (g)(1), (g)(2)(i) through (iii), (g)(2)(v), (g)(3)(i) and (ii), and (g)(5). For purposes of § 721.72(e), the concentration is set at 1.0%. For purposes of § 721.72(g)(1), this substance may cause: acute toxicity, skin irritation, serious eye damage, skin sensitization, genetic toxicity, and specific target organ toxicity. Alternative hazard and warning statements that meet the criteria of the Globally Harmonized System and OSHA Hazard Communication Standard may be used.
(iii)
Industrial, commercial, and consumer activities.
Requirements as specified in § 721.80(f), (k), and (t). It is a significant new use to import the substance other than in solution, unless in sealed containers weighing 5 kilograms or less. It is a significant new use to process the substance in any way that generates dust, mist, or aerosol in a non-enclosed process. It is a significant new use to manufacture the substance longer than 9 months.
(b) Specific requirements. The provisions of subpart A of this part apply to this section except as modified by this paragraph (b).
(1)
Recordkeeping.
Recordkeeping requirements as specified in § 721.125(a) through (i) are applicable to manufacturers, importers, and processors of this substance.
(2)
Limitation or revocation of certain notification requirements.
The provisions of § 721.185 apply to this section.
Sulfonium, tri(halosubstitutedphenyl)-, salt with heterosubstituteddifluorosubstitutedalkyl substitutedalkyl trihalosubstitutedcarbomonocycle carboxylate (1:1) (generic).
(a)
Chemical substance and significant new uses subject to reporting.
(1) The chemical substance identified generically as sulfonium, tri(halosubstitutedphenyl)-, salt with heterosubstituteddifluorosubstitutedalkyl substitutedalkyl trihalosubstitutedcarbomonocycle carboxylate (1:1) (PMN P-25-21) is subject to reporting under this section for the significant new uses described in paragraph (a)(2) of this section. The requirements of this section do not apply to quantities of the substance after they have been completely reacted or adhered (during photolithographic processes) onto a semiconductor wafer surface or similar manufactured article used in the production of semiconductor technologies.
(2) The significant new uses are:
(i)
Protection in the workplace.
Requirements as specified in § 721.63(a)(1), (a)(2)(i) and (a)(2)(iii), (a)(3), and (c). When determining which persons are reasonably likely to be exposed as required for § 721.63(a)(1), engineering control measures (
e.g.,
enclosure or confinement of the operation, general and local ventilation) or administrative control measures (
e.g.,
workplace policies and procedures) shall be considered and implemented to prevent exposure, where feasible.
(ii)
Hazard communication.
Requirements as specified in § 721.72(a) through (f), (g)(1), (g)(2)(i) through (iii), (g)(2)(v), (g)(3)(i) and (ii), and (g)(5). For purposes of § 721.72(e), the concentration is set at 1.0%. For purposes of § 721.72(g)(1), this substance may cause: acute toxicity, skin irritation, serious eye damage, skin sensitization, genetic toxicity, and specific target organ toxicity. Alternative hazard and warning statements that meet the criteria of the Globally Harmonized System and OSHA Hazard Communication Standard may be used.
(iii)
Industrial, commercial, and consumer activities.
Requirements as specified in § 721.80(f), (k), and (t). It is a significant new use to import the substance other than in solution, unless in sealed containers weighing 5 kilograms or less. It is a significant new use to process the substance in any way that generates dust, mist, or aerosol in a non-enclosed process. It is a significant new use to manufacture the substance longer than 9 months.
(b)
Specific requirements.
The provisions of subpart A of this part apply to this section except as modified by this paragraph (b).
(1)
Recordkeeping.
Recordkeeping requirements as specified in § 721.125(a) through (i) are applicable to manufacturers, importers, and processors of this substance.
(2)
Limitation or revocation of certain notification requirements.
The provisions of § 721.185 apply to this section.
Sulfonium, bis(dihalo carbomonocycle)carbomonocycle-, salt with trihalobenzoate (generic).
(a)
Chemical substance and significant new uses subject to reporting.
(1) The chemical substance identified generically as sulfonium, bis(dihalo carbomonocycle)carbomonocycle-, salt with trihalobenzoate (PMN P-25-67; Accession No. 303334) is subject to reporting under this section for the significant new uses described in paragraph (a)(2) of this section. The requirements of this section do not apply to quantities of the substance after they have been completely reacted or adhered (during photolithographic processes) onto a semiconductor wafer surface or similar manufactured article used in the production of semiconductor technologies.
(2) The significant new uses are:
(i)
Protection in the workplace.
Requirements as specified in § 721.63(a)(1), (a)(2)(i) and (2)(iii), (a)(3), and (c). When determining which persons are reasonably likely to be exposed as required for § 721.63(a)(1), engineering control measures (
e.g.,
enclosure or confinement of the operation, general and local ventilation) or administrative control measures (
e.g.,
workplace policies and procedures) shall be considered and implemented to prevent exposure, where feasible.
(ii)
Hazard communication.
Requirements as specified in § 721.72(a) through (f), (g)(1), (g)(2)(i) through (iii) and (g)(2)(v), (g)(3)(i) and (ii), and (g)(5). For purposes of § 721.72(e), the concentration is set at 1.0%. For purposes of § 721.72(g)(1), this substance may cause: acute toxicity, skin irritation, serious eye damage, skin sensitization, genetic toxicity, and specific target organ toxicity. Alternative hazard and warning statements that meet the criteria of the Globally Harmonized System and OSHA Hazard Communication Standard may be used.
(iii)
Industrial, commercial, and consumer activities.
Requirements as specified in § 721.80(f), (k), and (t). It is a significant new use to import the substance other than in solution, unless in sealed containers weighing 5
( printed page 31979)
kilograms or less. It is a significant new use to process the substance in any way that generates vapor, dust, mist, or aerosol in a non-enclosed process. It is a significant new use to manufacture the substance longer than 9 months.
(b)
Specific requirements.
The provisions of subpart A of this part apply to this section except as modified by this paragraph (b).
(1)
Recordkeeping.
Recordkeeping requirements as specified in § 721.125(a) through (i) are applicable to manufacturers, importers, and processors of this substance.
(2)
Limitation or revocation of certain notification requirements.
The provisions of § 721.185 apply to this section.
Use this for formal legal and research references to the published document.
91 FR 31962
Web Citation
Suggested Web Citation
Use this when citing the archival web version of the document.
“Significant New Use Rules on Certain Chemical Substances (25-2.5e),” thefederalregister.org (May 29, 2026), https://thefederalregister.org/documents/2026-10712/significant-new-use-rules-on-certain-chemical-substances-25-2-5e.