[Federal Register Volume 63, Number 239 (Monday, December 14, 1998)] [Notices] [Pages 68783-68785] From the Federal Register Online via the Government Publishing Office [www.gpo.gov] [FR Doc No: 98-33090] [[Page 68783]] ----------------------------------------------------------------------- DEPARTMENT OF HEALTH AND HUMAN SERVICES Public Health Service National Toxicology Program; Call for Public Comments on 11 Agents, Substances, Mixtures and Exposure Circumstances Proposed for Listing in or Delisting from the Report on Carcinogens, Ninth Edition Background The National Toxicology Program (NTP) solicits final public comments on additional agents, substances, mixtures and exposure circumstances for listing in or delisting from the Report on Carcinogens, Ninth Edition. This Report is a Congressionally mandated listing of known human carcinogens and reasonably anticipated human carcinogens and the Secretary, Department of Health and Human Services (HHS) delegates its preparation to the National Toxicology Program. Section 301(b)(4) of the Public Health Service Act, as amended, provides that the Secretary, (HHS), shall publish a report which contains a list of all substances (1) which either are known to be human carcinogens or may reasonably be anticipated to be human carcinogens; and (2) to which a significant number of persons residing in the United States (US) are exposed. The law also states that the reports should provide available information on the nature of exposures, the estimated number of persons exposed and the extent to which the implementation of Federal regulations decrease the risk to public health from exposure to these chemicals. In 1998, 11 substances or exposure circumstances were reviewed for listing in or removal from the Ninth Report. This review included two Federal and one non-government, scientific peer reviews and public comment and review. The three scientific review committee evaluated all available data relevant to the criteria for inclusion or removal of candidate substances or exposure circumstances in the Report. The criteria used in the review process and the detailed description of the review procedures, including the steps in the current formal review process, can be obtained by contacting: Dr. C.W. Jameson, National Toxicology Program, Report on Carcinogens, 79 Alexander Drive, Room 3217, P.O. Box 12233, Research Triangle Park, NC 27709; phone: (919) 541-4096, fax: (919) 541-2242, email: jameson@niehs.nih.gov. This information is also available on the NTP Home Page web site at ntp-server.niehs.nih.gov/ Public Comment Requested The NTP will be making a final recommendation in 1999 for the 11 substances or exposure circumstances reviewed in 1998, for either listing in, delisting from, or changing the current listing from reasonably anticipated to be a human carcinogen to the known to be a human carcinogen category in the Ninth Report. These nominated substances or exposure circumstances are provided in the following table with their Chemical Abstracts Services (CAS) Registry numbers (where available) and the recommendations from the three scientific peer reviews of the nominations. Background documents provided to the review committees and the interested public are available upon request. The NTP will review the recommendations of each of the review committees and consider the public comments received throughout the process in making decisions regarding the NTP recommendations to the Secretary, DHHS, for listing or removal of the nominated substances and exposure circumstances in the Ninth Edition of the Report on Carcinogens. The NTP solicits final public comment to supplement any previously submitted comments or to provide comments for the first time on any substance or exposure circumstances in the following table. Comments will be accepted for a period of 60 days from the date of the publication of this announcement in the Federal Register. Comments or questions should be directed to Dr. C.W. Jameson at the address listed above. Attachment Dated: December 4, 1998. Kenneth Olden, Director, National Toxicology Program. Summary of RG1,\1\ RG2 \2\ and NTP Board Subcommittee \3\ Recommendations for the Agents, Substances, Mixtures or Exposure Circumstances Reviewed in 1998 for Listing in or Delisting from the Report on Carcinogens,\4\ 9th Edition ---------------------------------------------------------------------------------------------------------------- NTP board Nomination/CAS No. Primary uses or RG1 action RG2 action subcommittee exposures action ---------------------------------------------------------------------------------------------------------------- Alcoholic Beverages............. Consumption of RG1 recommended (6 RG2 unanimously The Subcommittee alcoholic yes votes to 1 no recommended (7 recommended (9 beverages. vote) listing as yes votes to 0 no yes votes to 3 no known to be a votes) listing as votes with 1 human carcinogen. known to be a abstention) human carcinogen. listing as known to be a human carcinogen. Boot and Shoe Manufacture and Workers in the RG1 recommended (5 RG2 recommended (6 The Subcommittee Repair. boot and shoe yes votes to 1 no yes votes to 1 no unanimously manufacture and vote) that Boot vote) that Boot recommended (10 repair industry. and Shoe and Shoe yes votes to 0 no Manufacture and Manufacture and votes) to defer Repair in the Repair in the action on this United States be United States be nomination included in the included in the because of the RoC as having RoC as having lack of exposure been reviewed but been reviewed but assessment not formally not formally information. listed, due to listed, due to inadequate data. inadequate data. Diesel Exhaust Particulates..... Diesel engine RG1 defeated a RG2 recommended (6 The Subcommittee exhaust. motion to list as yes votes to 1 no recommended (9 reasonably vote) to list as yes votes to 0 no anticipated to be reasonably votes with 3 a human anticipated to be abstentions) to carcinogen (4 yes a human list as votes to 5 no carcinogen. reasonably votes). RG1 anticipated to be recommended (5 a human yes votes to 4 no carcinogen. votes) to list as known to be a human carcinogen. [[Page 68784]] Environmental Tobacco Smoke..... ``Passive'' RG1 recommended (7 RG2 recommended (5 The Subcommittee inhalation of yes votes to 0 no yes votes to 2 no unanimously tobacco smoke vote with 1 votes) to list as recommended (13 from abstention) to known to be a yes votes to 0 no environmental list as known to human carcinogen. votes) listing as sources. be a human known to be a carcinogen. human carcinogen. Ethyl Acrylate/140-88-5......... Monomer used to RG1 recommended (7 RG2 recommended (6 The Subcommittee produce polymers yes votes to 2 no yes votes to 1 no recommended (8 and copolymers votes) to delist vote) to delist yes votes to 2 no for use in latex from RoC. from RoC. votes with 2 paints, textiles, abstentions) to etc. delist from the RoC. Ethylene Oxide/75-21-8.......... Industrial RG1 recommended (6 RG2 unanimously The Subcommittee chemical used as yes votes to 1 no recommended (7 recommended (6 an intermediate vote) to upgrade yeas votes to 0 yes votes to 5 no in the to a known human no votes) to votes with 1 manufacture of carcinogen. upgrade to a abstention) to other chemicals; known human upgrade to a e.g., ethylene carcinogen. known human glycol and is carcinogen. widely used in the health care industry as a sterilant. Isoprene/78-79-5................ The monomeric unit RG1 unanimously RG2 recommended (6 The Subcommittee of natural rubber recommended (6 yes votes to 0 no unanimously and naturally yes votes to 0 no votes with 1 recommended (13 occurring votes) to list as abstention) to yes votes to 0 no terpenes and reasonably list as votes) to list as steroids and anticipated to be reasonably reasonably widely used in a human anticipated to be anticipated to be the production of carcinogen. a human a human isoprene- carcinogen. carcinogen. butadiene copolymers. Methyl-t-Butyl Ether/1634-04-4.. Used as an RG1 recommended (4 RG2 voted against The Subcommittee additive in yes votes to 3 no motion to list as voted against unleaded gasoline votes) to list as reasonably motion to list as in amounts up to reasonably anticipated to be reasonably 11%. anticipated to be a human anticipated to be a human carcinogen (3 yes a human carcinogen. votes to 4 no carcinogen (5 yes votes). votes to 6 no votes with 1 abstention). Nickel Compounds................ Many industrial RG1 unanimously RG2 recommended (4 The Subcommittee and commercial recommended (7 yes votes to 3 no unanimously applications. yes votes to 0 no votes with 1 recommended (12 votes) to upgrade abstention to yes votes to 0 no to a known human upgrade to a votes) to upgrade carcinogen. known human to a known human carcinogen. carcinogen. Silica, Crystalline (Respirable Exposure from RG1 unanimously RG2 recommended (5 The subcommittee Size)/7631-86-9. mining and recommended (9 yes votes to 2 no recommended (11 quarrying of coal yes votes to 0 no votes) to upgrade yes votes to 1 no and other votes) to upgrade to a known human vote) to upgrade minerals, stone to a known human carcinogen. to a known human cutting, carcinogen. carcinogen. production of glass and ceramics and in occupations such as sandblasting, polishing and grinding. 2,3,7,8-TETRACHLORODIBENZ O-P- Not used RG1 unanimously RG2 unanimously The Subcommittee DIOXIN (TCDD)/1746-01-6. commercially, recommended (10 recommended (8 voted against found as a yes votes to 0 no yes votes to 0 no motion to upgrade contaminant in votes) to upgrade votes) to upgrade current listing the production of to a known human to a known human to known human some pesticides carcinogen. carcinogen. carcinogen. (5 and other yes votes to 7 no commercial votes with 1 products. abstention). ---------------------------------------------------------------------------------------------------------------- \1\ The NIEHS Review Committee for the Report on Carcinogens (RG1). \2\ The NTP Executive Committee* Interagency Working Group for the Report on Carcinogens (RG2). *Agencies represented on the NTP Executive Committee include: Agency for Toxic Substances and Disease Registry (ATSDR), Consumer Product Safety Commission (CPSC), Environmental Protection Agency (EPA), Food and Drug Administration (FDA), National Center for Toxicological Research (NCTR), National Institute for Occupational Safety and Health (NIOSH), Occupational Safety and Health Administration (OSHA), Department of Health and Human Services (DHHS), National Institutes of Health (NIH), National Cancer Institute (NCI), National Library of Medicine (NLM), and National Institute of Environmental Health Sciences/NTP (NIEHS/NTP). \3\ The NTP Board of Scientific Counselor Report on Carcinogens Subcommittee (the External Peer Review Group). \4\ RoC-Report on Carcinogens. [[Page 68785]] [FR Doc. 98-33090 Filed 12-11-98; 8:45 am] BILLING CODE 4140-01-M
Document
National Toxicology Program; Call for Public Comments on 11 Agents, Substances, Mixtures and Exposure Circumstances Proposed for Listing in or Delisting from the Report on Carcinogens, Ninth Edition
[Federal Register Volume 63, Number 239 (Monday, December 14, 1998)] [Notices] [Pages 68783-68785] From the Federal Register Online via the Government Publishing Office [ www.gp...
www.gpo.gov
ntp-server.niehs.nih.gov/
PublicLegal Citation
Federal Register Citation
Use this for formal legal and research references to the published document.
63 FR 68783
Web Citation
Suggested Web Citation
Use this when citing the archival web version of the document.
“National Toxicology Program; Call for Public Comments on 11 Agents, Substances, Mixtures and Exposure Circumstances Proposed for Listing in or Delisting from the Report on Carcinogens, Ninth Edition,” thefederalregister.org (December 14, 1998), https://thefederalregister.org/documents/98-33090/national-toxicology-program-call-for-public-comments-on-11-agents-substances-mixtures-and-exposure-circumstances-propose.