80 FR 20236 - Eunice Kennedy Shriver National Institute of Child Health and Human Development Notice of Closed Meeting

DEPARTMENT OF HEALTH AND HUMAN SERVICES
National Institutes of Health

Federal Register Volume 80, Issue 72 (April 15, 2015)

Page Range		20236-20237
FR Document		2015-08572

Federal Register, Volume 80 Issue 72 (Wednesday, April 15, 2015)

[Federal Register Volume 80, Number 72 (Wednesday, April 15, 2015)]
[Notices]
[Pages 20236-20237]
From the Federal Register Online  [www.thefederalregister.org]
[FR Doc No: 2015-08572]


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DEPARTMENT OF HEALTH AND HUMAN SERVICES

National Institutes of Health


Eunice Kennedy Shriver National Institute of Child Health and 
Human Development Notice of Closed Meeting

    Pursuant to section 10(d) of the Federal Advisory Committee Act, as 
amended (5 U.S.C. App.), notice is hereby given of the following 
meeting.
    The meeting will be closed to the public in accordance with the 
provisions set forth in section 552b(c)(4) and 552b(c)(6), Title 5 
U.S.C., as amended. The grant applications and the discussions could 
disclose confidential trade secrets or commercial property such as 
patentable material, and personal information concerning individuals 
associated with the grant applications, the disclosure of which would 
constitute a clearly unwarranted invasion of personal privacy.

    Name of Committee: National Institute of Child Health and Human 
Development Special Emphasis Panel PDB-P2C_Infrastructure/Center 
Grants.
    Date: June 29, 2015.
    Time: 8:00 a.m. to 6:00 p.m.
    Agenda: To review and evaluate grant applications.

[[Page 20237]]

    Place: Doubletree Hotel Washington, 1515 Rhode Island Ave. NW., 
Washington, DC 20005.
    Contact Person: CARLA T. WALLS, Ph.D., Scientific Review 
Officer, Scientific Review Branch, EUNICE KENNEDY SHRIVER NATIONAL 
INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT, NIH, 6100 EXECUTIVE 
BOULEVARD, ROOM 5B01, BETHESDA, MD 20892-9304, (301) 435-6898, 
[email protected].

(Catalogue of Federal Domestic Assistance Program Nos. 93.864, 
Population Research; 93.865, Research for Mothers and Children; 
93.929, Center for Medical Rehabilitation Research; 93.209, 
Contraception and Infertility Loan Repayment Program, National 
Institutes of Health, HHS)

    Dated: April 9, 2015.
Carolyn Baum,
Program Analyst, Office of Federal Advisory Committee Policy.
[FR Doc. 2015-08572 Filed 4-14-15; 8:45 am]
 BILLING CODE 4140-01-P

20236 Federal Register / Vol. 80, No. 72 / Wednesday, April 15, 2015 / Notices

• Step 4: Authorized Organization ACTION: Notice. Information Collection Request Title:
Representative (AOR) Authorization Evaluation of Pregnancy Prevention
• Step 5: Track AOR Status SUMMARY: In compliance with section Approaches—First Follow-up
• Step 6: Register With Electronic 3507(a)(1)(D) of the Paperwork
Research Administration (eRA) Reduction Act of 1995, the Office of the Abstract: The Office of Adolescent
Commons Secretary (OS), Department of Health Health (OAH), U.S. Department of
Steps 1 through 5, in detail, can be and Human Services, has submitted an Health and Human Services (HHS) is
found at http://www07.grants.gov/ Information Collection Request (ICR), requesting an extension without change
applicants/organization_ described below, to the Office of of a currently approved information
registration.jsp. Step 6, in detail, can be Management and Budget (OMB) for collection request by OMB. The purpose
found at https://commons.era.nih.gov/ review and approval. The ICR is for of the extension is to complete the
commons/registration/ renewal of the approved information ongoing follow-up data collection for
registrationInstructions.jsp. After you collection assigned OMB control the Evaluation of Adolescent Pregnancy
have followed these steps, submit the number 0990–0382, scheduled to expire Prevention Approaches (PPA), a multi-
electronic application to: http:// on May 31, 2015. Comments submitted site random assignment evaluation of
www.grants.gov. during the first public review of this ICR promising approaches to teen pregnancy
will be provided to OMB. OMB will prevention.
Dated: April 8, 2015.
accept further comments from the Need and Proposed Use of the
Leslie Kux, Information: The PPA study is being
public on this ICR during the review
Associate Commissioner for Policy. and approval period. conducted in seven program sites
[FR Doc. 2015–08613 Filed 4–14–15; 8:45 am] around the country. The proposed
DATES: Comments on the ICR must be
BILLING CODE 4164–01–P
received on or before May 15, 2015. extension is necessary to complete
ongoing follow-up data collection in
ADDRESSES: Submit your comments to five of the seven study sites. The
DEPARTMENT OF HEALTH AND OIRA_submission@omb.eop.gov or via resulting data will be used in a rigorous
HUMAN SERVICES facsimile to (202) 395–5806. program impact analysis to assess the
FOR FURTHER INFORMATION CONTACT: effectiveness of each program in
Office of the Secretary Information Collection Clearance staff, reducing rates of teen pregnancy and
[Document Identifier: HHS–OS–0990–0382- Information.CollectionClearance@ associated sexual risk behaviors.
30–D] hhs.gov or (202) 690–6162. Likely Respondents: The 1484 youth
SUPPLEMENTARY INFORMATION: When participants who agreed to participate in
Agency Information Collection the study upon sample enrollment in 5
Activities; Submission to OMB for submitting comments or requesting
information, please include the OMB impact study sites.
Review and Approval; Public Comment
Request control number 0990–0382 and The total annual burden hours
document identifier HHS–OS–30D for estimated for this ICR are summarized
AGENCY: Office of the Secretary, HHS. reference. in the table below.

TOTAL ESTIMATED ANNUALIZED BURDEN—HOURS
Average
Number of
Number of burden per Total burden
Form name responses per
respondents response hours
respondent (in hours)

Oklahoma Institute for Child Advocacy (OICA) ............................................... 294 2 42/60 412
Ohio Health ...................................................................................................... 148 3 42/60 310
Children’s Hospital Los Angeles ...................................................................... 254 2 36/60 305
EngenderHealth ............................................................................................... 240 2 36/60 288
Princeton Center for Leadership Training ....................................................... 548 2 36/60 658

Total .......................................................................................................... ........................ ........................ ........................ 1,973

Terry S. Clark, DEPARTMENT OF HEALTH AND amended. The grant applications and
Assistant Information Collection Clearance HUMAN SERVICES the discussions could disclose
Officer. confidential trade secrets or commercial
[FR Doc. 2015–08541 Filed 4–14–15; 8:45 am] National Institutes of Health property such as patentable material,
BILLING CODE 4150–30–P
and personal information concerning
Eunice Kennedy Shriver National individuals associated with the grant
Institute of Child Health and Human applications, the disclosure of which
Development Notice of Closed Meeting would constitute a clearly unwarranted
invasion of personal privacy.
Pursuant to section 10(d) of the
Federal Advisory Committee Act, as Name of Committee: National Institute of
tkelley on DSK3SPTVN1PROD with NOTICES

amended (5 U.S.C. App.), notice is Child Health and Human Development
hereby given of the following meeting. Special Emphasis Panel PDB–P2C_
Infrastructure/Center Grants.
The meeting will be closed to the Date: June 29, 2015.
public in accordance with the Time: 8:00 a.m. to 6:00 p.m.
provisions set forth in section 552b(c)(4) Agenda: To review and evaluate grant
and 552b(c)(6), Title 5 U.S.C., as applications.

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Federal Register / Vol. 80, No. 72 / Wednesday, April 15, 2015 / Notices 20237

Place: Doubletree Hotel Washington, 1515 environmentally responsive genes may platforms. In Phase III, the focus is on
Rhode Island Ave. NW., Washington, DC also be useful in biomarker assaying chemicals in high-content
20005. development and basic research efforts. screens and mid to high throughput
Contact Person: CARLA T. WALLS, Ph.D., This list of genes, referred to as the transcriptomic screens. High throughput
Scientific Review Officer, Scientific Review
Branch, EUNICE KENNEDY SHRIVER
‘‘S1500’’ gene list, or gene set, is gene expression changes will be the
NATIONAL INSTITUTE OF CHILD HEALTH available for public comment. primary metric that is employed in
AND HUMAN DEVELOPMENT, NIH, 6100 DATES: The deadline for receipt of Phase III to measure biological effects
EXECUTIVE BOULEVARD, ROOM 5B01, comments is May 15, 2015. from chemical exposures.
BETHESDA, MD 20892–9304, (301) 435– ADDRESSES: Comments on the human To conduct Tox21 Phase III, Tox21
6898, wallsc@mail.nih.gov. S1500 gene set should be submitted partners initiated the ‘‘S1500 Genes
(Catalogue of Federal Domestic Assistance electronically in Microsoft Excel or High Throughput Transcriptomics’’
Program Nos. 93.864, Population Research; Word formats to Genelist@niehs.nih.gov. project to capture information from the
93.865, Research for Mothers and Children; Nominations for genes to be added to whole transcriptome (i.e., the entirety of
93.929, Center for Medical Rehabilitation all expressed RNA molecules in a cell
the S1500 must be accompanied with a
Research; 93.209, Contraception and
strong scientific justification for or biological sample). This project will
Infertility Loan Repayment Program, National
Institutes of Health, HHS) inclusion. use a targeted subset of genes in a HTS
FOR FURTHER INFORMATION CONTACT: Dr.
or semi-HTS platform to gain insight
Dated: April 9, 2015. into how biological systems respond to
Carolyn Baum, Elizabeth Maull, NIEHS, P.O. Box 12233
(MD K2–17), Research Triangle Park, NC chemical exposures. Neither the actual
Program Analyst, Office of Federal Advisory number of genes to be utilized, nor the
Committee Policy.
27709; email: maull@niehs.nih.gov.
specific transcriptomics platform(s)
SUPPLEMENTARY INFORMATION:
[FR Doc. 2015–08572 Filed 4–14–15; 8:45 am]
Background: In 2008, NIEHS/NTP, the needed to carry out the project, have
BILLING CODE 4140–01–P
U.S. Environmental Protection Agency’s been finalized.
(EPA) National Center for In an effort to select an appropriate
Computational Toxicology (NCCT), and subset of key representative or
DEPARTMENT OF HEALTH AND ‘‘sentinel’’ genes, the NTP previously
HUMAN SERVICES the National Human Genome Research
Institute (NHGRI)/NIH Chemical requested input from the scientific
Genomics Center (NCGC) (now located community (78 FR 45542, July 29, 2013)
National Institutes of Health on the ‘‘Nomination and Prioritization
within the National Center for
List of Environmentally Responsive Advancing Translational Sciences of Environmentally Responsive Genes
Human Genes Selected for Use In (NCATS)) entered into a formal for Use in Screening Large Numbers of
Screening Large Numbers of agreement to develop a vision and Substances Using Toxicogenomic
Substances Using Toxicogenomic devise an implementation strategy to Technologies.’’ An interagency working
Approaches shift the assessment of chemical hazards group composed of members of the
from traditional, experimental animal, Tox21 partnership considered the input
Request for Comments: The National toxicology studies to target-specific, provided in response to the Federal
Institute of Environmental Health mechanism-based, biological Register notice as they developed a
Sciences/National Toxicology Program observations largely obtained using in consensus strategy to select appropriate
requests comments on a list of vitro assays. In mid-2010, the U.S. Food genes.
environmentally responsive human and Drug Administration (FDA) joined The working group’s goal was to
genes selected for use in screening large the collaboration that is known select the most relevant and biologically
numbers of substances using informally as Tox21. diverse set of sentinel genes to represent
toxicogenomic approaches. Tox21 partner agencies collaborate to transcriptomic responses to injury.
SUMMARY: The National Institute of research, develop, validate, and Criteria for the selection and evaluation
Environmental Health Sciences translate innovative testing methods for of an appropriate gene set are: (1)
(NIEHS)/National Toxicology Program characterization of toxicity pathways; Representative of highly diverse gene
(NTP) requests comments on a set of identify compounds, assays, informatic expression changes reported to date, (2)
human genes that have been identified analyses, and targeted testing needed to capable of predicting the gene
and prioritized as environmentally support the development of new expression changes observed across the
responsive genes. These genes will be methods; identify patterns of transcriptome, and (3) coverage of all
used in toxicogenomics approaches to compound-induced biological major biological pathways.
screen cells or tissues obtained from response(s) in order to characterize The current version of the human
humans against large numbers of toxicity pathways; facilitate cross- S1500 gene set can be found at http://
chemicals. The goal was to generate a species and low-dose extrapolation; ntp.niehs.nih.gov/go/S1500. This site
set of approximately 1500 human genes prioritize compounds for more will be updated as changes to the list are
to evaluate transcriptional changes in extensive toxicological evaluation; and made. The consensus strategy for
response to chemical exposures. Similar develop predictive models for biological selection of an appropriate sentinel gene
gene sets will be developed for response in humans. The primary set can be accessed at the same site.
screening cells or tissues from other activity of Tox21 Phase I was the Comments on the human S1500 gene
species such as rats, mice, zebrafish, development of a quantitative high set should be submitted electronically
and Caenorhabditis elegans. The human throughput screening (qHTS) approach in Microsoft Excel or Word format to
tkelley on DSK3SPTVN1PROD with NOTICES

gene set should provide maximal for toxicology. The goal of Phase II was Genelist@niehs.nih.gov.
toxicogenomic information on effects the implementation of the qHTS Respondents to this request are asked
from chemical exposures that reflect approach in screening a 10,000 to provide their name, affiliation,
general cellular responses, independent compound library through a variety of address, and contact information
of cell type or species, and gene nuclear receptor agonist/antagonist and (including telephone and fax numbers,
expression changes that are specific by stress response pathway assays, and email address). The deadline for
organ and/or cell type. Such a list of utilizing primarily reporter gene receipt of comments is May 15, 2015.

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Document Created: 2015-12-18 11:13:47
Document Modified: 2015-12-18 11:13:47

Category		Regulatory Information
Collection		Federal Register
sudoc Class		AE 2.7: GS 4.107: AE 2.106:
Publisher		Office of the Federal Register, National Archives and Records Administration
Section		Notices
Dates		June 29, 2015.
FR Citation		80 FR 20236

80 FR 20236 - Eunice Kennedy Shriver National Institute of Child Health and Human Development Notice of Closed Meeting

DEPARTMENT OF HEALTH AND HUMAN SERVICESNational Institutes of Health

Federal Register Volume 80, Issue 72 (April 15, 2015)

DEPARTMENT OF HEALTH AND HUMAN SERVICES
National Institutes of Health