80 FR 79051 - Interagency Coordinating Committee on the Validation of Alternative Methods Communities of Practice Webinar on Fundamentals of Using Quantitative Structure-Activity Relationship Models and Read-across Techniques in Predictive Toxicology; Notice of Public Webinar; Registration Information
DEPARTMENT OF HEALTH AND HUMAN SERVICES
National Institutes of Health Federal Register Volume 80, Issue 243 (December 18, 2015)
National Institutes of Health
Federal Register Volume 80, Issue 243 (December 18, 2015)
| Page Range | 79051-79051 | |
| FR Document | 2015-31832 |
[Federal Register Volume 80, Number 243 (Friday, December 18, 2015)] [Notices] [Page 79051] From the Federal Register Online [www.thefederalregister.org] [FR Doc No: 2015-31832] ----------------------------------------------------------------------- DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Interagency Coordinating Committee on the Validation of Alternative Methods Communities of Practice Webinar on Fundamentals of Using Quantitative Structure-Activity Relationship Models and Read- across Techniques in Predictive Toxicology; Notice of Public Webinar; Registration Information SUMMARY: The Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) announces a public webinar ``Fundamentals of Using Quantitative Structure--Activity Relationship Models and Read- Across Techniques in Predictive Toxicology.'' The webinar is organized on behalf of ICCVAM by the National Toxicology Program Interagency Center for the Evaluation Alternative Toxicological Methods (NICEATM) and hosted by the U.S. Environmental Protection Agency's (EPA's) National Center for Computational Toxicology (NCCT). Interested persons may participate via Adobe[supreg] ConnectTM. Time is allotted for questions from the audience. DATES: Webinar: January 26, 2016, 1 p.m. to approximately 2:30 p.m. Eastern Standard Time (EST). Registration for Webinar: December 18, 2015 until January 26, 2016 at 2:30 p.m. ADDRESSES: Webinar Web page: http://ntp.niehs.nih.gov/go/commprac-2016. FOR FURTHER INFORMATION CONTACT: Dr. Warren S. Casey, Director, NICEATM; email: [email protected]; telephone: (919) 316-4729. SUPPLEMENTARY INFORMATION: Background: ICCVAM promotes the development and validation of toxicity testing methods that protect human health and the environment while replacing, reducing, or refining animal use. ICCVAM also provides guidance to test method developers and facilitates collaborations that promote the development of new test methods. To address these goals, ICCVAM is organizing a webinar on ``Fundamentals of Using Quantitative Structure--Activity Relationship Models and Read-across Techniques in Predictive Toxicology.'' Many commercial and environmental chemicals lack toxicity data necessary for users and risk assessors to make informed decisions about their potential health effects. Computational methods use data about structure, properties, and toxicity from tested chemicals to make predictions about the characteristics of untested chemicals. These include quantitative structure-activity relationship (QSAR) models, which predict the activities of chemicals with unknown properties by relating them to properties of known chemicals, and read-across, which uses toxicity data from a known (source) chemical to predict toxicity for another (target) chemical, usually but not always on the basis of structural similarity. Predictions made using these methods about toxicity of untested chemicals can help set priorities for future in vitro or in vivo testing, ensuring that the most important hazards are characterized first and that testing resources are used efficiently. The ICCVAM webinar will feature presentations by two experts in the development and application of QSAR models and read-across techniques. Alex Tropsha, Ph.D., associate dean for pharmacoinformatics and data science at the University of North Carolina at Chapel Hill, will discuss fundamentals of QSAR models. Louis (Gino) Scarano, Ph.D., of the EPA's Office of Pollution Prevention and Toxics, will describe read-across techniques and discuss the regulatory applications of QSAR models and read-across techniques. Webinar and Registration: This webinar is open to the public with time scheduled for questions by attendees following each presentation. Registration for the webinar is required and is open from December 18, 2015, through 2:30 p.m. on January 26, 2016. A link to registration is available at http://ntp.niehs.nih.gov/go/commprac-2016. Registrants will receive instructions on how to access and participate in the webinar in the email confirming their registration. The preliminary agenda is available at http://ntp.niehs.nih.gov/go/commprac-2016. Interested individuals are encouraged to visit this Web page to stay abreast of the most current webinar information. Individuals with disabilities who need accommodation to participate in this event should contact Ms. LaCresha Styles at phone: (919) 541- 3282 or email: [email protected]. TTY users should contact the Federal TTY Relay Service at (800) 877-8339. Requests should be made at least five business days in advance of the event. Background Information on ICCVAM and NICEATM: ICCVAM is an interagency committee composed of representatives from 15 federal regulatory and research agencies that require, use, generate, or disseminate toxicological and safety testing information. The ICCVAM Authorization Act of 2000 (42 U.S.C. 285l-3) establishes ICCVAM as a permanent interagency committee of the National Institute of Environmental Health Sciences and provides the authority for ICCVAM's involvement in activities relevant to the development of new and revised toxicological tests. ICCVAM conducts technical evaluations of new, revised, and alternative test methods and testing strategies with regulatory applicability and promotes the scientific validation and regulatory acceptance of test methods that both more accurately assess the safety and hazards of chemicals and products and replace, reduce, or refine (enhance animal well-being and lessen or avoid pain and distress) animal use. ICCVAM acts to ensure that new and revised test methods are validated to meet the needs of federal agencies, to increase the efficiency and effectiveness of federal agency test method review, and to optimize utilization of scientific expertise outside the federal government. Additional information about ICCVAM can be found at http://ntp.niehs.nih.gov/go/iccvam. NICEATM administers ICCVAM, provides scientific and operational support for ICCVAM activities, and conducts analyses and evaluations and coordinates independent validation studies on novel and high- priority alternative testing approaches. NICEATM and ICCVAM work collaboratively to evaluate new and improved test methods and strategies applicable to the needs of U.S. federal agencies. NICEATM and ICCVAM welcome the public nomination of new, revised, and alternative test methods and strategies for validation studies and technical evaluations. Additional information about NICEATM can be found at http://ntp.niehs.nih.gov/go/niceatm. Dated: December 15, 2015. John R. Bucher, Associate Director, National Toxicology Program. [FR Doc. 2015-31832 Filed 12-17-15; 8:45 am] BILLING CODE 4140-01-P
![Federal Register / Vol. 80, No. 243 / Friday, December 18, 2015 / Notices 79051
Dated: December 14, 2015. across Techniques in Predictive Requests should be made at least five
Melanie J. Gray, Toxicology.’’ business days in advance of the event.
Program Analyst, Office of Federal Advisory Many commercial and environmental Background Information on ICCVAM
Committee Policy. chemicals lack toxicity data necessary and NICEATM: ICCVAM is an
[FR Doc. 2015–31768 Filed 12–17–15; 8:45 am] for users and risk assessors to make interagency committee composed of
BILLING CODE 4140–01–P informed decisions about their potential representatives from 15 federal
health effects. Computational methods regulatory and research agencies that
use data about structure, properties, and
require, use, generate, or disseminate
DEPARTMENT OF HEALTH AND toxicity from tested chemicals to make
toxicological and safety testing
HUMAN SERVICES predictions about the characteristics of
information. The ICCVAM
untested chemicals. These include
National Institutes of Health Authorization Act of 2000 (42 U.S.C.
quantitative structure-activity
relationship (QSAR) models, which 285l–3) establishes ICCVAM as a
Interagency Coordinating Committee predict the activities of chemicals with permanent interagency committee of the
on the Validation of Alternative unknown properties by relating them to National Institute of Environmental
Methods Communities of Practice properties of known chemicals, and Health Sciences and provides the
Webinar on Fundamentals of Using read-across, which uses toxicity data authority for ICCVAM’s involvement in
Quantitative Structure–Activity from a known (source) chemical to activities relevant to the development of
Relationship Models and Read-across predict toxicity for another (target) new and revised toxicological tests.
Techniques in Predictive Toxicology; chemical, usually but not always on the ICCVAM conducts technical
Notice of Public Webinar; Registration basis of structural similarity. Predictions evaluations of new, revised, and
Information made using these methods about alternative test methods and testing
SUMMARY: The Interagency Coordinating toxicity of untested chemicals can help strategies with regulatory applicability
Committee on the Validation of set priorities for future in vitro or in vivo and promotes the scientific validation
Alternative Methods (ICCVAM) testing, ensuring that the most and regulatory acceptance of test
announces a public webinar important hazards are characterized first methods that both more accurately
‘‘Fundamentals of Using Quantitative and that testing resources are used assess the safety and hazards of
Structure—Activity Relationship efficiently. chemicals and products and replace,
Models and Read-Across Techniques in The ICCVAM webinar will feature reduce, or refine (enhance animal well-
Predictive Toxicology.’’ The webinar is presentations by two experts in the being and lessen or avoid pain and
organized on behalf of ICCVAM by the development and application of QSAR distress) animal use. ICCVAM acts to
National Toxicology Program models and read-across techniques. ensure that new and revised test
Interagency Center for the Evaluation Alex Tropsha, Ph.D., associate dean for methods are validated to meet the needs
Alternative Toxicological Methods pharmacoinformatics and data science of federal agencies, to increase the
(NICEATM) and hosted by the U.S. at the University of North Carolina at efficiency and effectiveness of federal
Environmental Protection Agency’s Chapel Hill, will discuss fundamentals agency test method review, and to
(EPA’s) National Center for of QSAR models. Louis (Gino) Scarano, optimize utilization of scientific
Computational Toxicology (NCCT). Ph.D., of the EPA’s Office of Pollution expertise outside the federal
Interested persons may participate via Prevention and Toxics, will describe government. Additional information
Adobe® ConnectTM. Time is allotted for read-across techniques and discuss the
about ICCVAM can be found at http://
questions from the audience. regulatory applications of QSAR models
ntp.niehs.nih.gov/go/iccvam.
DATES: Webinar: January 26, 2016, 1
and read-across techniques.
Webinar and Registration: This NICEATM administers ICCVAM,
p.m. to approximately 2:30 p.m. Eastern provides scientific and operational
Standard Time (EST). webinar is open to the public with time
scheduled for questions by attendees support for ICCVAM activities, and
Registration for Webinar: December conducts analyses and evaluations and
18, 2015 until January 26, 2016 at 2:30 following each presentation.
Registration for the webinar is required coordinates independent validation
p.m.
and is open from December 18, 2015, studies on novel and high-priority
ADDRESSES: Webinar Web page: http:// alternative testing approaches.
through 2:30 p.m. on January 26, 2016.
ntp.niehs.nih.gov/go/commprac-2016. A link to registration is available at NICEATM and ICCVAM work
FOR FURTHER INFORMATION CONTACT: Dr. http://ntp.niehs.nih.gov/go/commprac- collaboratively to evaluate new and
Warren S. Casey, Director, NICEATM; 2016. Registrants will receive improved test methods and strategies
email: warren.casey@nih.gov; telephone: instructions on how to access and applicable to the needs of U.S. federal
(919) 316–4729. participate in the webinar in the email agencies. NICEATM and ICCVAM
SUPPLEMENTARY INFORMATION: confirming their registration. welcome the public nomination of new,
Background: ICCVAM promotes the The preliminary agenda is available at revised, and alternative test methods
development and validation of toxicity http://ntp.niehs.nih.gov/go/commprac- and strategies for validation studies and
testing methods that protect human 2016. Interested individuals are technical evaluations. Additional
health and the environment while encouraged to visit this Web page to information about NICEATM can be
replacing, reducing, or refining animal stay abreast of the most current webinar found at http://ntp.niehs.nih.gov/go/
mstockstill on DSK4VPTVN1PROD with NOTICES
use. ICCVAM also provides guidance to information. niceatm.
test method developers and facilitates Individuals with disabilities who Dated: December 15, 2015.
collaborations that promote the need accommodation to participate in
development of new test methods. To this event should contact Ms. LaCresha John R. Bucher,
address these goals, ICCVAM is Styles at phone: (919) 541–3282 or Associate Director, National Toxicology
organizing a webinar on ‘‘Fundamentals email: styles.lacresha@epa.gov. TTY Program.
of Using Quantitative Structure— users should contact the Federal TTY [FR Doc. 2015–31832 Filed 12–17–15; 8:45 am]
Activity Relationship Models and Read- Relay Service at (800) 877–8339. BILLING CODE 4140–01–P
VerDate Sep<11>2014 19:20 Dec 17, 2015 Jkt 238001 PO 00000 Frm 00024 Fmt 4703 Sfmt 9990 E:\FR\FM\18DEN1.SGM 18DEN1](https://thefederalregister.org/doc/80_FR_79294/page/1.svg)
Document Created: 2015-12-18 01:38:24
Document Modified: 2015-12-18 01:38:24
| Category | Regulatory Information | |
| Collection | Federal Register | |
| sudoc Class | AE 2.7: GS 4.107: AE 2.106: | |
| Publisher | Office of the Federal Register, National Archives and Records Administration | |
| Section | Notices | |
| Dates | Webinar: January 26, 2016, 1 p.m. to approximately 2:30 p.m. Eastern Standard Time (EST). | |
| Contact | Dr. Warren S. Casey, Director, NICEATM; email: [email protected]; telephone: (919) 316-4729. | |
| FR Citation | 80 FR 79051 |
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