81 FR 62513 - Nominations to the National Toxicology Program for the Report on Carcinogens and Office of Health Assessment and Translation; Request for Information

DEPARTMENT OF HEALTH AND HUMAN SERVICES
National Institutes of Health

Federal Register Volume 81, Issue 175 (September 9, 2016)

The National Toxicology Program (NTP) requests information on four nominations. Four substances are being considered for possible review for future editions of the Report on Carcinogens (RoC). Three of these four substances are also being considered for evaluation of non- cancer health outcomes by the Office of Health Assessment and Translation (OHAT).

[Federal Register Volume 81, Number 175 (Friday, September 9, 2016)]
[Notices]
[Pages 62513-62514]
From the Federal Register Online  [www.thefederalregister.org]
[FR Doc No: 2016-21698]


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DEPARTMENT OF HEALTH AND HUMAN SERVICES

National Institutes of Health


Nominations to the National Toxicology Program for the Report on 
Carcinogens and Office of Health Assessment and Translation; Request 
for Information

SUMMARY: The National Toxicology Program (NTP) requests information on 
four nominations. Four substances are being considered for possible 
review for future editions of the Report on Carcinogens (RoC). Three of 
these four substances are also being considered for evaluation of non-
cancer health outcomes by the Office of Health Assessment and 
Translation (OHAT).

DATES: Receipt of information: Deadline is October 11, 2016.

ADDRESSES: Information on substances for possible review should be 
submitted electronically at http://ntp.niehs.nih.gov/go/778417.

FOR FURTHER INFORMATION CONTACT: 
    RoC Nominations: Dr. Ruth Lunn, Director, Office of RoC; telephone 
(919) 316-4637; [email protected]. OHAT Nominations: Dr. Windy Boyd, 
OHAT, telephone (919) 541-9810; [email protected]. Address for Dr. 
Lunn and Dr. Boyd: Division of NTP, National

[[Page 62514]]

Institute of Environmental Health Sciences, 111 T.W. Alexander Drive, 
P.O. Box 12233, Research Triangle Park, NC 27709.

SUPPLEMENTARY INFORMATION: 
    Request for Information: NTP requests information on four 
substances that have been nominated for possible review for future 
editions of the RoC (see http://ntp.niehs.nih.gov/go/rocnom); three of 
these four substances are also under consideration for evaluation of 
non-cancer health outcomes (see http://ntp.niehs.nih.gov/go/763346). 
The four nominations are:
     Consumption of red meat: cancer and non-cancer health 
hazard evaluations.
     Consumption of processed meat: cancer and non-cancer 
health hazard evaluations.
     Consumption of meat cooked at high temperatures: cancer 
and non-cancer health hazard evaluations.
     Antimony trioxide: cancer hazard evaluation.
    Cancer hazard evaluation of a substance for the RoC may seek to 
list a new substance in the report, reclassify the listing status of a 
substance already listed, or remove a listed substance.
    Specifically, NTP requests information on: (1) Current production, 
use patterns, and human exposure estimates for antimony trioxide; (2) 
data on dietary intake estimates of red meat, processed meat, or meat 
cooked at high temperatures; and for all four nominations (3) recently 
published, ongoing, or planned studies related to evaluating adverse 
health outcomes (e.g., cancer, development, reproductive, or 
immunological disorders); (4) scientific issues important for 
prioritizing and assessing adverse health outcomes; and (5) names of 
scientists with expertise or knowledge on any of these substances--
please indicate the substance and include any bibliographic citations 
when available. NTP will use this information in determining which 
substances to propose for formal health hazard evaluations.
    Information on substances for possible review should be submitted 
electronically at http://ntp.niehs.nih.gov/go/778417 or emailed to Dr. 
Lunn or Dr. Boyd (see FOR FURTHER INFORMATION CONTACT). Contact 
information for comments should include the submitter's name, 
affiliation, sponsoring organization (if any), telephone, and email. 
Written information received in response to this notice will be posted 
on the NTP Web site, and the submitter identified by name, affiliation, 
and/or sponsoring organization. Guidelines for public comments are at 
http://ntp.niehs.nih.gov/ntp/about_ntp/guidelines_public_comments_508.pdf.
    Responses to this request for information are voluntary. This 
request for information is for planning purposes only and is not a 
solicitation for applications or an obligation on the part of the U.S. 
Government to provide support for any ideas identified in response to 
it. Please note that the U.S. Government will not pay for the 
preparation of any information submitted or for its use. No 
proprietary, classified, confidential, or sensitive information should 
be included in your response.
    Background Information on ORoC: On behalf of NTP, ORoC prepares the 
RoC following an established, four-part process (http://ntp.niehs.nih.gov/go/rocprocess). The RoC is a congressionally 
mandated, science-based, public health report that identifies agents, 
substances, mixtures, or exposures (collectively called ``substances'') 
in our environment that pose a cancer hazard for people in the United 
States. Published biennially, each edition of the RoC is cumulative and 
consists of substances newly reviewed in addition to those listed in 
previous editions. Newly reviewed substances with their recommended 
listing are reviewed and approved by the Secretary of Health and Human 
Services. The 13th RoC, the latest edition, was published on October 2, 
2014 (available at http://ntp.niehs.nih.gov/go/roc13). The 14th RoC is 
under development.
    Background Information on OHAT: On behalf of NTP, OHAT conducts 
literature-based evaluations to assess the evidence whether 
environmental chemicals, physical substances, or mixtures (collectively 
called ``substances'') cause adverse non-cancer health outcomes. As 
part of these evaluations, NTP may also provide opinions on whether 
these substances might be of concern for causing adverse effects on 
human health given what is known about toxicity and current human 
exposure levels. Information about OHAT can be found at http://ntp.niehs.nih.gov/go/ohat.

    Dated: September 6, 2016.
John R. Bucher,
Associate Director, National Toxicology Program.
[FR Doc. 2016-21698 Filed 9-8-16; 8:45 am]
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