81 FR 62514 - Government-Owned Inventions; Availability for Licensing
DEPARTMENT OF HEALTH AND HUMAN SERVICES
National Institutes of Health Federal Register Volume 81, Issue 175 (September 9, 2016)
National Institutes of Health
Federal Register Volume 81, Issue 175 (September 9, 2016)
| Page Range | 62514-62515 | |
| FR Document | 2016-21699 |
[Federal Register Volume 81, Number 175 (Friday, September 9, 2016)] [Notices] [Pages 62514-62515] From the Federal Register Online [www.thefederalregister.org] [FR Doc No: 2016-21699] ----------------------------------------------------------------------- DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Government-Owned Inventions; Availability for Licensing AGENCY: National Institutes of Health, HHS. ACTION: Notice. ----------------------------------------------------------------------- SUMMARY: The inventions listed below are owned by an agency of the U.S. Government and are available for licensing in the U.S. in accordance with 35 U.S.C. 209 and 37 CFR part 404 to achieve expeditious commercialization of results of federally-funded research and development. FOR FURTHER INFORMATION CONTACT: Licensing information may be obtained by emailing the indicated licensing contact at the National Heart, Lung, and Blood, Office of Technology Transfer and Development Office of Technology Transfer, 31 Center Drive, Room 4A29, MSC2479, Bethesda, MD 20892-2479; telephone: 301-402-5579. A signed Confidential Disclosure Agreement may be required to receive any unpublished information. SUPPLEMENTARY INFORMATION: Technology description follows. Reagent for Mapping Genome-Wide Enhancer-Promoter Interactions This invention is a research reagent named the ``bivalent Tn5 complex'' used in transposition-mediated analysis of chromatin looping (TrAC-looping) to determine genome-wide enhancer-promoter interactions during studies of 4D nucleomes in normal development and disease conditions. Enhancer-promoter interactions are key in temporospatial control of gene expression during normal development and pathological conditions. Currently available methods of analyzing genome-wide enhancer-promoter interactions are insufficient in achieving necessary resolution, give rise to false positive artifacts due to in vitro ligation steps, or too expensive due to the necessity of sequencing over a billion reads. The instant reagent and associated TrAC-looping technique effectively reduce false positive detection and achieve a 10 to 100-times higher resolution at lower cost for mapping genome-wide interactions between enhancers and promotes essential for the control of gene expression in normal development and pathological conditions. References --Lieberman-Aiden E et al., Science 2009 Oct 9;326(5950):289-93. [[Page 62515]] --Rao S et al., Cell. 2014 Dec 18;159(7):1665-80. --Goryshin et al., JBC 1998 March 273(13) 7367-7374. Potential Commercial Applications --Genome wide Enhancer-Promoter mapping --Functional annotation of genomic structure --Three-dimensional chromatin organization --Analysis of 4D Nucleomes during development of diseases --Identification of key genomic sequences involved in diseases --Diagnostic for diseases associated with aberrant gene expression Competitive Advantages --Transposition mediated analysis of chromatin looping Development Stage: Research reagent. Inventors: Keji Zhao and Qingsong Tang (both of NHLBI). Intellectual Property: HHS Reference No. E-266-2016/0;--Research reagent. Licensing Contact: Michael Shmilovich, Esq, CLP; 301-435-5019; [email protected]. Dated: September 2, 2016. Michael Shmilovich, Senior Licensing and Patenting Manager, National Heart, Lung, and Blood Institute, Office of Technology Transfer and Development. [FR Doc. 2016-21699 Filed 9-8-16; 8:45 am] BILLING CODE 4140-01-P
![62514 Federal Register / Vol. 81, No. 175 / Friday, September 9, 2016 / Notices
Institute of Environmental Health organization. Guidelines for public DEPARTMENT OF HEALTH AND
Sciences, 111 T.W. Alexander Drive, comments are at http:// HUMAN SERVICES
P.O. Box 12233, Research Triangle Park, ntp.niehs.nih.gov/ntp/about_ntp/
NC 27709. guidelines_public_comments_508.pdf. National Institutes of Health
SUPPLEMENTARY INFORMATION: Responses to this request for Government-Owned Inventions;
Request for Information: NTP requests information are voluntary. This request Availability for Licensing
information on four substances that for information is for planning purposes
have been nominated for possible only and is not a solicitation for AGENCY: National Institutes of Health,
review for future editions of the RoC applications or an obligation on the part HHS.
(see http://ntp.niehs.nih.gov/go/ of the U.S. Government to provide ACTION: Notice.
rocnom); three of these four substances
support for any ideas identified in SUMMARY: The inventions listed below
are also under consideration for
response to it. Please note that the U.S. are owned by an agency of the U.S.
evaluation of non-cancer health
outcomes (see http://ntp.niehs.nih.gov/ Government will not pay for the Government and are available for
go/763346). The four nominations are: preparation of any information licensing in the U.S. in accordance with
• Consumption of red meat: cancer submitted or for its use. No proprietary, 35 U.S.C. 209 and 37 CFR part 404 to
and non-cancer health hazard classified, confidential, or sensitive achieve expeditious commercialization
evaluations. information should be included in your of results of federally-funded research
• Consumption of processed meat: response. and development.
cancer and non-cancer health hazard Background Information on ORoC: On FOR FURTHER INFORMATION CONTACT:
evaluations. behalf of NTP, ORoC prepares the RoC Licensing information may be obtained
• Consumption of meat cooked at following an established, four-part by emailing the indicated licensing
high temperatures: cancer and non- process (http://ntp.niehs.nih.gov/go/ contact at the National Heart, Lung, and
cancer health hazard evaluations. rocprocess). The RoC is a Blood, Office of Technology Transfer
• Antimony trioxide: cancer hazard congressionally mandated, science- and Development Office of Technology
evaluation. based, public health report that Transfer, 31 Center Drive, Room 4A29,
Cancer hazard evaluation of a identifies agents, substances, mixtures, MSC2479, Bethesda, MD 20892–2479;
substance for the RoC may seek to list or exposures (collectively called telephone: 301–402–5579. A signed
a new substance in the report, reclassify ‘‘substances’’) in our environment that Confidential Disclosure Agreement may
the listing status of a substance already be required to receive any unpublished
pose a cancer hazard for people in the
listed, or remove a listed substance. information.
United States. Published biennially,
Specifically, NTP requests SUPPLEMENTARY INFORMATION:
information on: (1) Current production, each edition of the RoC is cumulative
and consists of substances newly Technology description follows.
use patterns, and human exposure
estimates for antimony trioxide; (2) data reviewed in addition to those listed in Reagent for Mapping Genome-Wide
on dietary intake estimates of red meat, previous editions. Newly reviewed Enhancer-Promoter Interactions
processed meat, or meat cooked at high substances with their recommended This invention is a research reagent
temperatures; and for all four listing are reviewed and approved by named the ‘‘bivalent Tn5 complex’’
nominations (3) recently published, the Secretary of Health and Human used in transposition-mediated analysis
ongoing, or planned studies related to Services. The 13th RoC, the latest of chromatin looping (TrAC-looping) to
evaluating adverse health outcomes edition, was published on October 2, determine genome-wide enhancer-
(e.g., cancer, development, 2014 (available at http:// promoter interactions during studies of
reproductive, or immunological ntp.niehs.nih.gov/go/roc13). The 14th 4D nucleomes in normal development
disorders); (4) scientific issues RoC is under development. and disease conditions. Enhancer-
important for prioritizing and assessing Background Information on OHAT: promoter interactions are key in
adverse health outcomes; and (5) names On behalf of NTP, OHAT conducts temporospatial control of gene
of scientists with expertise or literature-based evaluations to assess the expression during normal development
knowledge on any of these substances— evidence whether environmental and pathological conditions. Currently
please indicate the substance and available methods of analyzing genome-
chemicals, physical substances, or
include any bibliographic citations wide enhancer-promoter interactions
mixtures (collectively called
when available. NTP will use this are insufficient in achieving necessary
information in determining which ‘‘substances’’) cause adverse non-cancer
resolution, give rise to false positive
substances to propose for formal health health outcomes. As part of these
artifacts due to in vitro ligation steps, or
hazard evaluations. evaluations, NTP may also provide
too expensive due to the necessity of
Information on substances for opinions on whether these substances sequencing over a billion reads. The
possible review should be submitted might be of concern for causing adverse instant reagent and associated TrAC-
electronically at http:// effects on human health given what is looping technique effectively reduce
ntp.niehs.nih.gov/go/778417 or emailed known about toxicity and current false positive detection and achieve a 10
to Dr. Lunn or Dr. Boyd (see FOR human exposure levels. Information to 100-times higher resolution at lower
FURTHER INFORMATION CONTACT). Contact about OHAT can be found at http://
asabaliauskas on DSK3SPTVN1PROD with NOTICES
cost for mapping genome-wide
information for comments should ntp.niehs.nih.gov/go/ohat. interactions between enhancers and
include the submitter’s name, Dated: September 6, 2016. promotes essential for the control of
affiliation, sponsoring organization (if gene expression in normal development
John R. Bucher,
any), telephone, and email. Written and pathological conditions.
information received in response to this Associate Director, National Toxicology
notice will be posted on the NTP Web Program. References
site, and the submitter identified by [FR Doc. 2016–21698 Filed 9–8–16; 8:45 am] —Lieberman-Aiden E et al., Science
name, affiliation, and/or sponsoring BILLING CODE 4140–01–P 2009 Oct 9;326(5950):289–93.
VerDate Sep<11>2014 17:11 Sep 08, 2016 Jkt 238001 PO 00000 Frm 00045 Fmt 4703 Sfmt 4703 E:\FR\FM\09SEN1.SGM 09SEN1](https://thefederalregister.org/doc/81_FR_62689/page/1.svg)
![Federal Register / Vol. 81, No. 175 / Friday, September 9, 2016 / Notices 62515
—Rao S et al., Cell. 2014 Dec test has been a success, as ACE has announcing its plan to begin a phased
18;159(7):1665–80. proven capable of receiving and decommissioning of ACS for entry and
—Goryshin et al., JBC 1998 March processing the data required by FSIS, entry summary filings, making ACE the
273(13) 7367–7374. and sharing that data with FSIS. sole CBP-authorized electronic data
Accordingly, this NCAP test will be interchange (EDI) system for processing
Potential Commercial Applications
concluded on October 11, 2016. CBP has those electronic filings. See 81 FR 10264
—Genome wide Enhancer-Promoter made ACE the sole CBP-authorized (February 29, 2016). As part of this
mapping electronic data interchange (EDI) system phased decommissioning, CBP
—Functional annotation of genomic for most entry and entry summary announced that ACE would become the
structure filings, including entry and entry sole CBP-authorized EDI for processing
—Three-dimensional chromatin summary filings for meat, poultry and certain electronic entries and entry
organization egg products regulated by FSIS. As a summaries for merchandise subject to
—Analysis of 4D Nucleomes during result, filers transmitting electronic the import requirements of the Food and
development of diseases import data required by FSIS with their Drug Administration on June 15, 2016.
—Identification of key genomic electronic entry or entry summary must See 81 FR 30320 (May 16, 2016). On
sequences involved in diseases use ACE. July 23, 2016, CBP completed this
—Diagnostic for diseases associated DATES: The NCAP test will conclude on phased decommissioning, and ACE
with aberrant gene expression October 11, 2016. became the sole CBP-authorized EDI
Competitive Advantages ADDRESSES: Comments concerning this system for most entry and entry
notice and any aspect of this test may summary filings for all filers. See 81 FR
—Transposition mediated analysis of 32339 (May 23, 2016). Entries and entry
chromatin looping be submitted via email to Josephine
Baiamonte, ACE Business Office (ABO), summaries for the entry types specified
Development Stage: Research reagent. in the May 23, 2016 notice, including
Office of Trade, at
Inventors: Keji Zhao and Qingsong entries and entry summaries
josephine.baiamonte@cbp.dhs.gov.
Tang (both of NHLBI). accompanied by data required by the
Intellectual Property: HHS Reference FOR FURTHER INFORMATION CONTACT: For
CBP-related questions, contact Jeffrey Food Safety and Inspection Service
No. E–266–2016/0;—Research reagent. (FSIS), must be filed in ACE. ACS is no
Licensing Contact: Michael Nii, Director, Inter-Agency
Collaboration Division, Office of Trade, longer available for these filings.
Shmilovich, Esq, CLP; 301–435–5019;
shmilovm@mail.nih.gov. at jeffrey.c.nii@cbp.dhs.gov. II. The Partner Government Agency
Dated: September 2, 2016.
SUPPLEMENTARY INFORMATION: Message Set Test for FSIS Data
Michael Shmilovich, I. Background The Partner Government Agency
Senior Licensing and Patenting Manager, The National Customs Automation (PGA) Message Set is the data required
National Heart, Lung, and Blood Institute, Program (NCAP) was established by to satisfy a PGA’s reporting
Office of Technology Transfer and Subtitle B of Title VI—Customs requirements through ACE. It enables
Development. the trade community to submit trade-
Modernization, in the North American
[FR Doc. 2016–21699 Filed 9–8–16; 8:45 am] Free Trade Agreement Implementation related data required by the PGA only
BILLING CODE 4140–01–P Act (Pub. L. 103–182, 107 Stat. 2057, once to CBP, thus improving
December 8, 1993) (Customs communications between the agency
Modernization Act). See 19 U.S.C. 1411. and filers, and shortening entry
DEPARTMENT OF HOMELAND Through NCAP, the thrust of customs processing time. Also, by virtue of being
SECURITY modernization was on trade compliance electronic, the PGA Message Set
and the development of the Automated eliminates the necessity for the
U.S. Customs and Border Protection Commercial Environment (ACE), the submission and subsequent manual
planned successor to the legacy processing of paper documents.
Conclusion of the National Customs Through the Customs Modernization
Automated Commercial System (ACS).
Automation Program (NCAP) Test Act and section 101.9 of title 19 of the
ACE is an automated and electronic
Concerning the Submission of Data Code of Federal Regulations (19 CFR
system for commercial trade processing.
Required by the Food Safety and 101.9(b)), the Commissioner of CBP has
ACE will streamline business processes,
Inspection Service (FSIS) in the authority to conduct limited test
facilitate growth in trade, ensure cargo
Automated Commercial Environment programs or procedures designed to
security, and foster participation in
(ACE) evaluate planned components of the
global commerce, while ensuring
AGENCY: U.S. Customs and Border compliance with U.S. laws and NCAP. See Treasury Decision (T.D.) 95–
Protection, Department of Homeland regulations and reducing costs for U.S. 21.
Security. Customs and Border Protection (CBP) On December 13, 2013, CBP
ACTION: General notice. and its communities of interest. The published a notice in the Federal
ability to meet these objectives depends Register announcing CBP’s plan to
SUMMARY: This document announces the upon successfully modernizing CBP’s conduct an NCAP test concerning the
conclusion of the National Customs business functions and the information electronic transmission of the PGA
Automation Program (NCAP) test technology that supports those Message Set data elements required by
asabaliauskas on DSK3SPTVN1PROD with NOTICES
concerning the electronic transmission functions. CBP’s modernization efforts FSIS for the importation of certain meat,
of certain import data required by the are accomplished through phased poultry, and egg products to CBP
Food Safety and Inspection Service releases of ACE component through ACE. See 78 FR 75931
(FSIS) to the Automated Commercial functionality, designed to introduce a (December 13, 2013). Under this test,
Environment (ACE) using the Partner new capability or to replace a specific the PGA Message Set satisfied the FSIS
Government Agency (PGA) Message Set. legacy ACS function. data requirements for electronic entries
U.S. Customs and Border Protection On February 29, 2016, CBP published filed in ACE and enabled the trade
(CBP) has determined that the NCAP a notice in the Federal Register community to use the CBP-managed
VerDate Sep<11>2014 17:11 Sep 08, 2016 Jkt 238001 PO 00000 Frm 00046 Fmt 4703 Sfmt 4703 E:\FR\FM\09SEN1.SGM 09SEN1](https://thefederalregister.org/doc/81_FR_62689/page/2.svg)
Document Created: 2018-02-09 13:15:01
Document Modified: 2018-02-09 13:15:01
| Category | Regulatory Information | |
| Collection | Federal Register | |
| sudoc Class | AE 2.7: GS 4.107: AE 2.106: | |
| Publisher | Office of the Federal Register, National Archives and Records Administration | |
| Section | Notices | |
| Action | Notice. | |
| Contact | Licensing information may be obtained by emailing the indicated licensing contact at the National Heart, Lung, and Blood, Office of Technology Transfer and Development Office of Technology Transfer, 31 Center Drive, Room 4A29, MSC2479, Bethesda, MD 20892-2479; telephone: 301-402-5579. A signed Confidential Disclosure Agreement may be required to receive any unpublished information. | |
| FR Citation | 81 FR 62514 |
2025 Federal Register | Disclaimer | Privacy Policy
USC | CFR | eCFR