81 FR 70690 - Government-Owned Inventions; Availability for Licensing
DEPARTMENT OF HEALTH AND HUMAN SERVICES
National Institutes of Health Federal Register Volume 81, Issue 198 (October 13, 2016)
National Institutes of Health
Federal Register Volume 81, Issue 198 (October 13, 2016)
| Page Range | 70690-70691 | |
| FR Document | 2016-24693 |
[Federal Register Volume 81, Number 198 (Thursday, October 13, 2016)] [Notices] [Pages 70690-70691] From the Federal Register Online [www.thefederalregister.org] [FR Doc No: 2016-24693] ----------------------------------------------------------------------- DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Government-Owned Inventions; Availability for Licensing AGENCY: National Institutes of Health, HHS. ACTION: Notice. ----------------------------------------------------------------------- SUMMARY: The inventions listed below are owned by an agency of the U.S. Government and are available for licensing in the U.S. in accordance with 35 U.S.C. 209 and 37 CFR part 404 to achieve expeditious commercialization of federally-funded research and development. Foreign patent applications are filed on selected inventions to extend market coverage for companies and may also be available for licensing. FOR FURTHER INFORMATION CONTACT: Licensing information and copies of the U.S. patent applications listed below may be obtained by writing to the indicated licensing contact at the National Heart, Lung and Blood Institute, Office of Technology Transfer and Development, National Institutes of Health, 31 Center Drive Room 4A29, MSC2479, Bethesda, MD 20892-2479; telephone: 301-402-5579. A signed Confidential Disclosure Agreement may be required to receive copies of the patent applications. SUPPLEMENTARY INFORMATION: Technology descriptions follow. Enhanced Functionalization of Carbon Nanoparticles for Biomedical Applications Description of Technology The invention pertains to methods of increasing the density of carboxylic acids on the surface of a carbon nanoparticle that can be functionalized with biologically relevant molecules, such as antibodies or peptides, for biomedical applications. Advantageously, the method could increase functionalization of a nanoparticle by at least about 1x10\7\ functional groups/g of nanoparticle. The method includes contacting an oxygen-containing functional group on a surface of a carbon nanoparticle with a reducing agent to provide a hydroxyl group; reacting the hydroxyl group with a diazoacetate ester in the presence of a transition metal catalyst to provide an ester and then cleaving the ester to provide a carboxylic acid group. The carboxylic acid can further be secondarily functionalized to an acyl chloride, an amide, pegylated, a biotinylate, a folate, a thiol, a maleimide, an active ester, an amine, a chelated gadolinium, an azide, an alkyne, a protein tag, or a dendrimer. Examples of notable nanoparticles that can be derivatized using this method include carbon nanoparticles such as carbon nanotubes, fullerenes, graphenes, graphene oxides, and nanodiamonds; with or without fluorescent properties. Fluorescent nanoparticles are of particular interest for functionalization as they are applicable to both research and [[Page 70691]] diagnostic applications and can be visualized through microscopy. Potential Commercial ApplicationsImaging Therapeutics Competitive Advantages Higher degree of functionalization for carbon nanoparticles Development Stage Early Stage Inventors: Keir Neuman, Rolf Swenson, Ganesh Shenoy, Chandrasekhar Mushti (all of NHLBI). Publications: 1. Mochalin, V. N.; Shenderova, O.; Ho, D.; Gogotsi, Y., The Properties and Applications of Nanodiamonds. Nature Nanotechnology 2012, 7 (1), 11-23. 2. Huang, J.; Deming, C. P.; Song, Y.; Kang, X.; Zhou, Z.-Y.; Chen, S., Chemical Analysis of Surface Oxygenated Moieties of Fluorescent Carbon Nanoparticles. Nanoscale 2012, 4 (3), 1010-1015. 3. Nystrom, R. F.; Brown, W. G., Reduction of Organic Compounds by Lithium Aluminum Hydride. I. Aldehydes, Ketones, Esters, Acid Chlorides and Acid Anhydrides. Journal of the American Chemical Society 1947, 69 (5), 1197-1199. 4. Nystrom, R. F.; Brown, W. G., Reduction of Organic Compounds by Lithium Aluminum Hydride. Ii. Carboxylic Acids. Journal of the American Chemical Society 1947, 69 (10), 2548-2549. 5. Aller, E.; Brown, D. S.; Cox, G. G.; Miller, D. J.; Moody, C. J. Diastereoselectivity in the O-H Insertion Reactions of Rhodium Carbenoids Derived from Phenyldiazoacetates of Chiral Alcohols. Preparation Of .Alpha.-Hydroxy And .Alpha.-Alkoxy Esters. The Journal of Organic Chemistry 1995, 60 (14), 4449-4460. 6. Hoehnel, S; Lutolf, M.P., Capturing Cell-Cell Interactions via SNAP-tag and CLIP-tag Techology. Bioconjugate Chemistry 2015, 26, 1678-1686. 7. Moon, W. K.; Lin, Y.; O'Loughlin, T.; Tang, Y.; Kim, D.-E.; Weissleder, R.; and Tung, C.-H., Enhanced Tumor Detection Using a Folate Receptor-Targeted Near-Infrared Fluorochrome Conjugate. Bioconjugate Chemistry 2003, 14, 539-545. 8. Fu, C. C.,Lee, H. Y., Chen, K. C., Lim, T. S.,Wu, H. Y., Lin, P. K.,Wei, P. K., Tsao, P. H., Chang, H. C., Fann, W. Characterization and application of single fluorescent nanodiamonds as cellular biomarkers. Proceedings of the National Academy of Sciences of the United States of America, 2007, 104(3), 727-732. 9. Chang, B. M., Lin, H. H., Su, L. J., Lin, W. D., Lin, R. J., Tzeng, Y. K, Lee, R. T., Lee, Y. C., Yu, A. L., Chang, H. C., Highly Fluorescent Nanodiamonds Protein-Functionalized for Cell Labeling and Targeting. Advanced Functional Materials 23(46): 5737-5745. Intellectual Property: HHS Reference No. E-207-2016/0. US Provisional Patent Application No. 62/402,339 filed 30 September 2016. Licensing Contact: Michael Shmilovich, Esq, CLP; 301-435-5019; [email protected]. Dated: October 6, 2016. Michael Shmilovich, National Heart, Lung and Blood Institute, Office of Technology Transfer and Development, National Institutes of Health. [FR Doc. 2016-24693 Filed 10-12-16; 8:45 am] BILLING CODE 4140-01-P
![70690 Federal Register / Vol. 81, No. 198 / Thursday, October 13, 2016 / Notices
Closed: April 6, 2017, 12:00 p.m. to 4:30 DEPARTMENT OF HEALTH AND licensing in the U.S. in accordance with
p.m. HUMAN SERVICES 35 U.S.C. 209 and 37 CFR part 404 to
Agenda: To review and evaluate personal achieve expeditious commercialization
qualifications, performance, and competence National Institutes of Health of federally-funded research and
of individual investigators. development. Foreign patent
Place: National Library of Medicine, National Institute of Allergy and applications are filed on selected
Building 38, 2nd Floor, The Lindberg Room, Infectious Diseases; Notice of Closed inventions to extend market coverage
8600 Rockville Pike, Bethesda, MD 20892. Meeting for companies and may also be available
Closed: April 7, 2017, 9:00 a.m. to 10:00
Pursuant to section 10(d) of the for licensing.
a.m.
Federal Advisory Committee Act, as FOR FURTHER INFORMATION CONTACT:
Agenda: To review and evaluate personal
amended (5 U.S.C. App.), notice is Licensing information and copies of the
qualifications, performance, and competence
hereby given of the following meeting. U.S. patent applications listed below
of individual investigators.
The meeting will be closed to the may be obtained by writing to the
Place: National Library of Medicine,
public in accordance with the indicated licensing contact at the
Building 38, 2nd Floor, The Lindberg Room,
provisions set forth in sections National Heart, Lung and Blood
8600 Rockville Pike, Bethesda, MD 20892.
Contact Person: Karen Steely, Program 552b(c)(4) and 552b(c)(6), Title 5 U.S.C., Institute, Office of Technology Transfer
Assistant, Lister Hill National Center for as amended. The grant applications and and Development, National Institutes of
Biomedical Communications, National the discussions could disclose Health, 31 Center Drive Room 4A29,
Library of Medicine, Building 38A, Room confidential trade secrets or commercial MSC2479, Bethesda, MD 20892–2479;
7S707, Bethesda, MD 20892, 301–827–4385, property such as patentable material, telephone: 301–402–5579. A signed
ksteely@mail.nih.gov. and personal information concerning Confidential Disclosure Agreement may
individuals associated with the grant be required to receive copies of the
Open: April 7, 2017, 10:00 a.m. to 11:30
applications, the disclosure of which patent applications.
a.m.
Agenda: Review of research and
would constitute a clearly unwarranted SUPPLEMENTARY INFORMATION:
development programs and preparation of
invasion of personal privacy. Technology descriptions follow.
reports of the Lister Hill National Center for Name of Committee: National Institute of
Allergy and Infectious Diseases Special
Enhanced Functionalization of Carbon
Biomedical Communications.
Emphasis Panel; Human Tissue Models For Nanoparticles for Biomedical
Place: National Library of Medicine,
Infectious Diseases (U19). Applications
Building 38, 2nd Floor, The Lindberg Room,
Date: November 16, 2016. Description of Technology
8600 Rockville Pike, Bethesda, MD 20892.
Time: 11:00 a.m. to 2:30 p.m.
Contact Person: Karen Steely, Program
Agenda: To review and evaluate grant The invention pertains to methods of
Assistant, Lister Hill National Center for applications.
Biomedical Communications, National
increasing the density of carboxylic
Place: National Institutes of Health, 5601 acids on the surface of a carbon
Library of Medicine, Building 38A, Room Fishers Lane, Rockville, MD 20892
7S707, Bethesda, MD 20892, 301–827–4385,
nanoparticle that can be functionalized
(Telephone Conference Call).
ksteely@mail.nih.gov. Contact Person: Brenda Lange-Gustafson, with biologically relevant molecules,
Ph.D., Scientific Review Officer, NIAID/NIH/ such as antibodies or peptides, for
Any interested person may file written
DHHS, Scientific Review Program, 5601 biomedical applications.
comments with the committee by forwarding
Fishers Lane, Room 3G13, Rockville, MD Advantageously, the method could
the statement to the Contact Person listed on
20852, 240–669–5047, bgustafson@ increase functionalization of a
this notice. The statement should include the niaid.nih.gov. nanoparticle by at least about 1x107
name, address, telephone number and when
(Catalogue of Federal Domestic Assistance functional groups/g of nanoparticle. The
applicable, the business or professional
Program Nos. 93.855, Allergy, Immunology, method includes contacting an oxygen-
affiliation of the interested person. and Transplantation Research; 93.856,
In the interest of security, NIH has
containing functional group on a surface
Microbiology and Infectious Diseases of a carbon nanoparticle with a reducing
instituted stringent procedures for entrance Research, National Institutes of Health, HHS)
onto the NIH campus. All visitor vehicles, agent to provide a hydroxyl group;
Dated: October 6, 2016. reacting the hydroxyl group with a
including taxicabs, hotel, and airport shuttles
will be inspected before being allowed on Natasha M. Copeland, diazoacetate ester in the presence of a
campus. Visitors will be asked to show one Program Analyst, Office of Federal Advisory transition metal catalyst to provide an
form of identification (for example, a Committee Policy. ester and then cleaving the ester to
government-issued photo ID, driver’s license, [FR Doc. 2016–24686 Filed 10–12–16; 8:45 am] provide a carboxylic acid group. The
or passport) and to state the purpose of their BILLING CODE 4140–01–P carboxylic acid can further be
visit. secondarily functionalized to an acyl
(Catalogue of Federal Domestic Assistance
chloride, an amide, pegylated, a
Program No. 93.879, Medical Library DEPARTMENT OF HEALTH AND biotinylate, a folate, a thiol, a
Assistance, National Institutes of Health, HUMAN SERVICES maleimide, an active ester, an amine, a
HHS) chelated gadolinium, an azide, an
National Institutes of Health alkyne, a protein tag, or a dendrimer.
Dated: October 5, 2016. Examples of notable nanoparticles that
Michelle Trout, Government-Owned Inventions; can be derivatized using this method
Availability for Licensing include carbon nanoparticles such as
Program Analyst, Office of Federal Advisory
Lhorne on DSK30JT082PROD with NOTICES
Committee Policy. AGENCY: National Institutes of Health, carbon nanotubes, fullerenes,
[FR Doc. 2016–24705 Filed 10–12–16; 8:45 am] HHS. graphenes, graphene oxides, and
BILLING CODE 4140–01–P ACTION: Notice. nanodiamonds; with or without
fluorescent properties. Fluorescent
SUMMARY: The inventions listed below nanoparticles are of particular interest
are owned by an agency of the U.S. for functionalization as they are
Government and are available for applicable to both research and
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![Federal Register / Vol. 81, No. 198 / Thursday, October 13, 2016 / Notices 70691
diagnostic applications and can be Intellectual Property: HHS Reference October 5, 2016.
visualized through microscopy. No. E–207–2016/0. Michelle Trout,
Potential Commercial Applications • US Provisional Patent Application Program Analyst, Office of Federal Advisory
Committee Policy.
No. 62/402,339 filed 30 September
• Imaging [FR Doc. 2016–24694 Filed 10–12–16; 8:45 am]
• Therapeutics 2016.
BILLING CODE 4140–01–P
Licensing Contact: Michael
Competitive Advantages Shmilovich, Esq, CLP; 301–435–5019;
• Higher degree of functionalization for shmilovm@mail.nih.gov. DEPARTMENT OF HEALTH AND
carbon nanoparticles HUMAN SERVICES
Dated: October 6, 2016.
Development Stage Michael Shmilovich, National Institutes of Health
• Early Stage National Heart, Lung and Blood Institute,
Inventors: Keir Neuman, Rolf Office of Technology Transfer and Notice of Diabetes Mellitus Interagency
Swenson, Ganesh Shenoy, Development, National Institutes of Health. Coordinating Committee meeting
Chandrasekhar Mushti (all of NHLBI). [FR Doc. 2016–24693 Filed 10–12–16; 8:45 am]
SUMMARY: The Diabetes Mellitus
BILLING CODE 4140–01–P Interagency Coordinating Committee
Publications:
(DMICC) will hold a meeting on October
1. Mochalin, V. N.; Shenderova, O.; Ho, D.; 18, 2016. The subject of the meeting will
Gogotsi, Y., The Properties and DEPARTMENT OF HEALTH AND be ‘‘How Reproducible Are People?
Applications of Nanodiamonds. Nature HUMAN SERVICES Understanding Health Histories Using
Nanotechnology 2012, 7 (1), 11–23.
2. Huang, J.; Deming, C. P.; Song, Y.; Kang, Medicare Claims Data.’’ The meeting is
National Institutes of Health open to the public.
X.; Zhou, Z.-Y.; Chen, S., Chemical
Analysis of Surface Oxygenated Moieties DATES: The meeting will be held on
National Heart, Lung, and Blood
of Fluorescent Carbon Nanoparticles. October 18, 2016; from 1:00 p.m. to 3:30
Nanoscale 2012, 4 (3), 1010–1015.
Institute; Notice of Closed Meeting
p.m. Individuals wanting to present oral
3. Nystrom, R. F.; Brown, W. G., Reduction comments must notify the contact
of Organic Compounds by Lithium Pursuant to section 10(d) of the person at least 10 days before the
Aluminum Hydride. I. Aldehydes, Federal Advisory Committee Act, as meeting date.
Ketones, Esters, Acid Chlorides and Acid amended (5 U.S.C. App.), notice is
Anhydrides. Journal of the American ADDRESSES: The meeting will be held in
hereby given of the following meeting. the Democracy 2 Building at 6707
Chemical Society 1947, 69 (5), 1197–
1199. The meeting will be closed to the Democracy Blvd., Bethesda, MD, in
4. Nystrom, R. F.; Brown, W. G., Reduction public in accordance with the Conference Room 7050.
of Organic Compounds by Lithium provisions set forth in sections FOR FURTHER INFORMATION CONTACT: For
Aluminum Hydride. Ii. Carboxylic 552b(c)(4) and 552b(c)(6), Title 5 U.S.C., further information concerning this
Acids. Journal of the American Chemical meeting, see the DMICC Web site,
as amended. The grant applications and
Society 1947, 69 (10), 2548–2549.
5. Aller, E.; Brown, D. S.; Cox, G. G.; Miller, the discussions could disclose www.diabetescommittee.gov, or contact
D. J.; Moody, C. J. Diastereoselectivity in confidential trade secrets or commercial Dr. B. Tibor Roberts, Executive
the O–H Insertion Reactions of Rhodium property such as patentable material, Secretary of the Diabetes Mellitus
Carbenoids Derived from and personal information concerning Interagency Coordinating Committee,
Phenyldiazoacetates of Chiral Alcohols. individuals associated with the grant National Institute of Diabetes and
Preparation Of .Alpha.-Hydroxy And applications, the disclosure of which Digestive and Kidney Diseases, 31
.Alpha.-Alkoxy Esters. The Journal of Center Drive, Building 31A, Room
Organic Chemistry 1995, 60 (14), 4449–
would constitute a clearly unwarranted
invasion of personal privacy. 9A19, MSC 2560, Bethesda, MD 20892–
4460. 2560, telephone: 301–496–6623; FAX:
6. Hoehnel, S; Lutolf, M.P., Capturing Cell- Name of Committee: Heart, Lung, and 301–480–6741; email: dmicc@
Cell Interactions via SNAP-tag and CLIP- Blood Initial Review Group; NHLBI
tag Techology. Bioconjugate Chemistry
mail.nih.gov.
Mentored Transition to Independence
2015, 26, 1678–1686. SUPPLEMENTARY INFORMATION: The
Review Committee.
7. Moon, W. K.; Lin, Y.; O’Loughlin, T.; Tang, DMICC, chaired by the National
Y.; Kim, D.-E.; Weissleder, R.; and Tung, Date: November 3–4, 2016.
Time: 8:00 a.m. to 5:00 p.m.
Institute of Diabetes and Digestive and
C.-H., Enhanced Tumor Detection Using Kidney Diseases (NIDDK) comprising
a Folate Receptor-Targeted Near-Infrared Agenda: To review and evaluate grant
applications.
members of the Department of Health
Fluorochrome Conjugate. Bioconjugate
Place: The William F. Bolger Center, 9600 and Human Services and other federal
Chemistry 2003, 14, 539–545.
8. Fu, C. C.,Lee, H. Y., Chen, K. C., Lim, T. Newbridge Drive, Potomac, MD 20854. agencies that support diabetes-related
S.,Wu, H. Y., Lin, P. K.,Wei, P. K., Tsao, Contact Person: Giuseppe Pintucci, Ph.D., activities, facilitates cooperation,
P. H., Chang, H. C., Fann, W. Scientific Review Officer, Office of Scientific communication, and collaboration on
Characterization and application of Review/DERA, National Heart, Lung, and diabetes among government entities.
single fluorescent nanodiamonds as Blood Institute, 6701 Rockledge Drive, Room DMICC meetings, held several times a
cellular biomarkers. Proceedings of the year, provide an opportunity for
7192, Bethesda, MD 20892, 301–435–0287,
National Academy of Sciences of the Committee members to learn about and
United States of America, 2007, 104(3), Pintuccig@nhlbi.nih.gov.
discuss current and future diabetes
727–732. (Catalogue of Federal Domestic Assistance
Lhorne on DSK30JT082PROD with NOTICES
programs in DMICC member
9. Chang, B. M., Lin, H. H., Su, L. J., Lin, W. Program Nos. 93.233, National Center for
organizations and to identify
D., Lin, R. J., Tzeng, Y. K, Lee, R. T., Lee, Sleep Disorders Research; 93.837, Heart and
Y. C., Yu, A. L., Chang, H. C., Highly opportunities for collaboration. The
Vascular Diseases Research; 93.838, Lung
Fluorescent Nanodiamonds Protein- October 18, 2016 DMICC meeting will
Diseases Research; 93.839, Blood Diseases
Functionalized for Cell Labeling and focus on How Reproducible Are People?
and Resources Research, National Institutes
Targeting. Advanced Functional Understanding Health Histories Using
of Health, HHS)
Materials 23(46): 5737–5745. Medicare Claims Data.
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Document Created: 2016-10-13 00:53:40
Document Modified: 2016-10-13 00:53:40
| Category | Regulatory Information | |
| Collection | Federal Register | |
| sudoc Class | AE 2.7: GS 4.107: AE 2.106: | |
| Publisher | Office of the Federal Register, National Archives and Records Administration | |
| Section | Notices | |
| Action | Notice. | |
| Contact | Licensing information and copies of the U.S. patent applications listed below may be obtained by writing to the indicated licensing contact at the National Heart, Lung and Blood Institute, Office of Technology Transfer and Development, National Institutes of Health, 31 Center Drive Room 4A29, MSC2479, Bethesda, MD 20892-2479; telephone: 301-402-5579. A signed Confidential Disclosure Agreement may be required to receive copies of the patent applications. | |
| FR Citation | 81 FR 70690 |
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