83_FR_16443 83 FR 16370 - Findings of Research Misconduct

83 FR 16370 - Findings of Research Misconduct

DEPARTMENT OF HEALTH AND HUMAN SERVICES
Office of the Secretary

Federal Register Volume 83, Issue 73 (April 16, 2018)

Page Range16370-16371
FR Document2018-07782

Notice is hereby given that on April 2, 2018, the Department of Health and Human Services (HHS) Debarring Official, on behalf of the Secretary of HHS, issued a final notice of debarment based on the findings of research misconduct made by the Office of Research Integrity (ORI) against H.M. Krishna Murthy, Ph.D., former Research Associate Professor, Department of Vision Sciences, University of Alabama at Birmingham (UAB). Dr. Murthy engaged in research misconduct in research supported by U.S. Public Health Service (PHS) grants, specifically National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), grants R01 AI051615, R01 AI032078, and R01 AI045623; National Heart, Lung, and Blood Institute (NHLBI), NIH, grants P01 HL034343 and R01 HL064272; and National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), NIH, grant R01 DK046900. The administrative actions, including ten (10) years of debarment, were implemented beginning on April 2, 2018, and are detailed below.

Federal Register, Volume 83 Issue 73 (Monday, April 16, 2018)
[Federal Register Volume 83, Number 73 (Monday, April 16, 2018)]
[Notices]
[Pages 16370-16371]
From the Federal Register Online  [www.thefederalregister.org]
[FR Doc No: 2018-07782]


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DEPARTMENT OF HEALTH AND HUMAN SERVICES

Office of the Secretary


Findings of Research Misconduct

AGENCY: Office of the Secretary, HHS.

ACTION: Notice.

-----------------------------------------------------------------------

SUMMARY: Notice is hereby given that on April 2, 2018, the Department 
of Health and Human Services (HHS) Debarring Official, on behalf of the 
Secretary of HHS, issued a final notice of debarment based on the 
findings of research misconduct made by the Office of Research 
Integrity (ORI) against H.M. Krishna Murthy, Ph.D., former Research 
Associate Professor, Department of Vision Sciences, University of 
Alabama at Birmingham (UAB).
    Dr. Murthy engaged in research misconduct in research supported by 
U.S. Public Health Service (PHS) grants, specifically National 
Institute of Allergy and Infectious Diseases (NIAID), National 
Institutes of Health (NIH), grants R01 AI051615, R01 AI032078, and R01 
AI045623; National Heart, Lung, and Blood Institute (NHLBI), NIH, 
grants P01 HL034343 and R01 HL064272; and National Institute of 
Diabetes and Digestive and Kidney Diseases (NIDDK), NIH, grant R01 
DK046900. The administrative actions, including ten (10) years of 
debarment, were implemented beginning on April 2, 2018, and are 
detailed below.

FOR FURTHER INFORMATION CONTACT:  Wanda K. Jones, Dr.P.H., Interim 
Director, Office of Research Integrity, 1101 Wootton Parkway, Suite 
750, Rockville, MD 20852, (240) 453-8200.

SUPPLEMENTARY INFORMATION: Notice is hereby given that HHS has taken 
final action in the following case:
    H.M. Krishna Murthy, Ph.D., University of Alabama at Birmingham: 
Based on evidence and findings of an investigation conducted by UAB, 
ORI's review of UAB's investigation, and additional evidence obtained 
and analysis conducted by ORI in its oversight review of UAB's 
investigation, ORI found that Dr. H.M. Krishna Murthy (Respondent), 
former Research Associate Professor, Department of Vision Sciences, 
UAB, committed research misconduct in research supported by PHS grants, 
specifically NIAID, NIH, grants R01 AI051615, R01 AI032078, and R01 
AI045623; NHLBI, NIH, grants P01 HL034343 and R01 HL064272; and NIDDK, 
NIH, grant R01 DK046900.
    Falsified and/or fabricated research was reported in:

 Nature 444:221-225, 2006 (hereafter referred to as ``Nature 
2006''); retracted in: Nature 532:268, 2016 April 14
 J. Biol. Chem. 274:5573-5580, 1999 (hereafter referred to 
as ``J. Biol. Chem. 1999''); retracted in: J. Biol. Chem. 284:34468, 
2009
 Proc. Natl. Acad. Sci. USA 101:8924-8929, 2004 (hereafter 
referred to as ``PNAS 2004''); Editorial Expression of Concern in: 
PNAS 107:6551, 2010 April 6
 Biochem. 44:10757-10765, 2005 (hereafter referred to as 
``Biochem. 2005'')
 Proc. Natl. Acad. Sci. USA 103:2126-2131, 2006 (hereafter 
referred to as ``PNAS 2006''); Editorial Expression of Concern in: 
PNAS 107:6551, 2010 April 6
 Acta Cryst. D55:1971-1977, 1999 (hereafter referred to as 
``Acta Cryst. 1999''); retracted in: Acta Cryst. D66:222, 2010
 J. Mol. Biol. 301:759-767, 2000 (hereafter referred to as 
``J. Mol. Biol. 2000''); retracted in: J. Mol. Biol. 397:1119, 2010
 Cell 104:301-311, 2001 (hereafter referred to as ``Cell 
2001'')
 Biochem. 41:11681-11691, 2002 (hereafter referred to as 
``Biochem. 2002'')
 Protein Data Bank (PDB) identification codes 2HR0, 1BEF, 
1RID, 1Y8E, 2A01, 1CMW, 2QID, 1DF9, 1G40, 1G44, 2OU1, and 1L6L (the 
PDB is funded in part by NIH)

    Falsified and/or fabricated research results also were 
referenced in the following PHS grant applications:

 1 R21 AI056224-01 submitted to NIAID, NIH
 1 R01 AI064509-01 submitted to NIAID, NIH
 1 R01 AI64509-01A1 submitted to NIAID, NIH
 1 R01 AI051615-01A1 submitted to NIAID, NIH
 1 R03 TW006840-01 submitted to Fogarty International Center 
(FIC), NIH


[[Page 16371]]


    ORI found by a preponderance of the evidence that Respondent 
intentionally, knowingly, or recklessly engaged in research misconduct 
by falsifying and/or fabricating X-ray crystallographic data for eleven 
(11) protein structures and falsely reporting them as experimentally 
derived from X-ray diffraction experiments in nine (9) publications and 
in twelve (12) deposits in the PDB. ORI found that Respondent 
intentionally, knowingly, or recklessly falsified and/or fabricated the 
PDB coordinate files deposited for all of the eleven (11) structures 
(PDB entries 2HR0, 1BEF, 1RID, 1Y8E, 2A01, 1CMW, 1G40, 1G44, 2OU1, 
1L6L, 2QID, and 1DF9) and the X-ray diffraction data (structure 
factors) corresponding to six (6) of the eleven (11) structures (PDB 
entries 2HR0, 1BEF, 1RID, 1Y8E, 2A01, and 1CMW).
    Specifically, Respondent falsified and/or fabricated:

 The protein crystal structure of complement component C3b 
reported in Nature 2006 and the corresponding structure factors and 
coordinate file deposited in the PDB for entry 2HR0
 the protein crystal structure of dengue virus NS3 serine 
protease reported in J. Biol. Chem. 1999 and the corresponding 
structure factors and coordinate file deposited in the PDB for entry 
1BEF
 the protein crystal structure of vaccinia virus complement 
control protein (VCP) in complex with heparin reported in PNAS 2004 and 
the corresponding structure factors and coordinate file deposited in 
the PDB for entry 1RID
 the protein crystal structure of VCP in complex with suramin 
(VCP-suramin) reported in Biochem. 2005 and the corresponding structure 
factors and coordinate file deposited in the PDB for entry 1Y8E
 the protein crystal structure of apolipoprotein A-I reported 
in PNAS 2006 and the corresponding structure factors and coordinate 
file deposited in the PDB for entry 2A01
 the protein crystal structure of Taq DNA polymerase reported 
in Acta Cryst. 1999 and the corresponding structure factors and 
coordinate file deposited in the PDB for entry 1CMW
 the protein crystal structure of VCP crystal form I reported 
in Cell 2001 and the corresponding coordinate files deposited in the 
PDB for entry 1G40
 the protein crystal structure of VCP crystal form II reported 
in Cell 2001 and the corresponding coordinate file deposited in the PDB 
for entry 1G44
 the protein crystal structure of apolipoprotein A-II reported 
in Biochem. 2002 and the corresponding coordinate file deposited in the 
PDB for entry 2OU1
 the protein crystal structure of apolipoprotein A-II in 
complex with [beta]-octyl glucoside reported in Biochem. 2002 and the 
corresponding coordinate file deposited in the PDB for entry IL6L
 the protein crystal structure of dengue virus NS3 protease in 
complex with a Bowman-Birk inhibitor reported in J. Mol. Biol. 2000 and 
the corresponding coordinate files deposited in the PDB for entries 
2QID and 1DF9

    ORI issued a charge letter enumerating the above findings of 
research misconduct and proposing HHS administrative actions. 
Respondent subsequently requested a hearing before an Administrative 
Law Judge (ALJ) of the Departmental Appeals Board to dispute these 
findings. ORI filed a motion for summary judgment, which Respondent 
opposed. On January 19, 2018, the ALJ issued a recommended decision to 
the Acting Assistant Secretary for Health (ASH) granting summary 
judgment in favor of ORI and sustaining ORI's proposal to impose a ten-
year debarment and a ten-year ban on PHS advisory services against 
Respondent as well as correction of Respondent's research record. The 
Acting ASH served a copy of the ALJ's recommended decision on the HHS 
Debarring Official pursuant to 42 CFR 93.523(c), and the decision 
constituted the findings of fact to the HHS Debarring Official in 
accordance with 2 CFR 180.845(c). On April 2, 2018, the HHS Debarring 
Official issued a final notice of debarment to begin on April 2, 2018, 
and end on April 1, 2028. Thus, the research misconduct findings set 
forth above became effective, and the following administrative actions 
have been implemented, beginning on April 2, 2018:
    (1) Dr. Murthy is debarred for a period of ten (10) years from 
eligibility for any contracting or subcontracting with any agency of 
the United States Government and from eligibility for or involvement in 
nonprocurement programs of the United States Government, referred to as 
``covered transactions,'' pursuant to HHS' Implementation (2 CFR part 
376) of Office of Management and Budget (OMB) Guidelines to Agencies on 
Governmentwide Debarment and Suspension (2 CFR part 180);
    (2) Dr. Murthy is prohibited from serving in any advisory capacity 
to PHS including, but not limited to, service on any PHS advisory 
committee, board, and/or peer review committee, or as a consultant for 
a period of ten (10) years; and
    (3) ORI will send a notice to the pertinent journals of the 
following publications that require retraction or correction and to the 
PDB for the following entries that require obsolescence, in accordance 
with 42 CFR 93.407(a)(1) and 93.411(b):

--Cell 104:301-311, 2001
--Biochem. 41:11681-11691, 2002
--Proc. Natl. Acad. Sci. USA 101:8924-8929, 2004
--Biochem. 44:10757-10765, 2005
--Proc. Natl. Acad. Sci. USA 103:2126-2131, 2006
--PDB entries 1RID, 1Y8E, 2A01, 1G40, 1G44, 2OU1, and 1L6L

Wanda K. Jones,
Interim Director, Office of Research Integrity.
[FR Doc. 2018-07782 Filed 4-13-18; 8:45 am]
 BILLING CODE 4150-31-P



                                                16370                          Federal Register / Vol. 83, No. 73 / Monday, April 16, 2018 / Notices

                                                requests. See the SUPPLEMENTARY                         dietary supplements containing caffeine               1101 Wootton Parkway, Suite 750,
                                                INFORMATION section for electronic                      that do not present a significant or                  Rockville, MD 20852, (240) 453–8200.
                                                access to the guidance document.                        unreasonable risk of illness or injury.               SUPPLEMENTARY INFORMATION:     Notice is
                                                FOR FURTHER INFORMATION CONTACT:                           The guidance represents our current                hereby given that HHS has taken final
                                                Sibyl Swift, Office of Dietary                          thinking on dietary supplements                       action in the following case:
                                                Supplement Programs, Center for Food                    containing high concentrations of
                                                                                                        caffeine. It does not establish any rights              H.M. Krishna Murthy, Ph.D.,
                                                Safety and Applied Nutrition, Food and
                                                                                                        for any person and is not binding on                  University of Alabama at Birmingham:
                                                Drug Administration, 5001 Campus Dr.,
                                                                                                        FDA or the public. You can use an                     Based on evidence and findings of an
                                                College Park, MD 20740, 240–402–1455.
                                                                                                        alternative approach if it satisfies the              investigation conducted by UAB, ORI’s
                                                SUPPLEMENTARY INFORMATION:                                                                                    review of UAB’s investigation, and
                                                                                                        requirements of the applicable statutes
                                                I. Background                                           and regulations. This guidance is not                 additional evidence obtained and
                                                                                                        subject to Executive Order 12866.                     analysis conducted by ORI in its
                                                   We are announcing the availability of                                                                      oversight review of UAB’s investigation,
                                                a guidance for industry entitled ‘‘Highly               II. Electronic Access                                 ORI found that Dr. H.M. Krishna Murthy
                                                Concentrated Caffeine in Dietary                                                                              (Respondent), former Research
                                                Supplements.’’ We are issuing this                        Persons with access to the internet
                                                                                                        may obtain the document at either                     Associate Professor, Department of
                                                guidance consistent with our good                                                                             Vision Sciences, UAB, committed
                                                guidance practices (GGP) regulation 21                  https://www.fda.gov/FoodGuidances or
                                                                                                        https://www.regulations.gov.                          research misconduct in research
                                                CFR 10.115. In accordance with 21 CFR                                                                         supported by PHS grants, specifically
                                                § 10.115(g)(2), we are issuing this                       Dated: April 11, 2018.                              NIAID, NIH, grants R01 AI051615, R01
                                                guidance without prior public comment                   Leslie Kux,                                           AI032078, and R01 AI045623; NHLBI,
                                                because we have determined that prior                   Associate Commissioner for Policy.                    NIH, grants P01 HL034343 and R01
                                                public participation is not feasible or                 [FR Doc. 2018–07836 Filed 4–13–18; 8:45 am]           HL064272; and NIDDK, NIH, grant R01
                                                appropriate in light of the threat to the                                                                     DK046900.
                                                                                                        BILLING CODE 4164–01–P
                                                public health that is posed by pure and
                                                highly concentrated caffeine products,                                                                          Falsified and/or fabricated research
                                                which have been linked to several                                                                             was reported in:
                                                                                                        DEPARTMENT OF HEALTH AND
                                                deaths in recent years. Although this                   HUMAN SERVICES                                        • Nature 444:221–225, 2006 (hereafter
                                                guidance is immediately in effect, it                                                                           referred to as ‘‘Nature 2006’’); retracted in:
                                                remains subject to comment in                           Office of the Secretary                                 Nature 532:268, 2016 April 14
                                                accordance with FDA’s GGP regulation.                                                                         • J. Biol. Chem. 274:5573–5580, 1999
                                                                                                        Findings of Research Misconduct                         (hereafter referred to as ‘‘J. Biol. Chem.
                                                   In this guidance, we are announcing
                                                                                                                                                                1999’’); retracted in: J. Biol. Chem.
                                                that we consider some dietary                                                                                   284:34468, 2009
                                                supplements containing high                             AGENCY:   Office of the Secretary, HHS.
                                                                                                                                                              • Proc. Natl. Acad. Sci. USA 101:8924–8929,
                                                concentrations of caffeine to be                        ACTION:   Notice.                                       2004 (hereafter referred to as ‘‘PNAS
                                                adulterated and informing industry                                                                              2004’’); Editorial Expression of Concern in:
                                                about characteristics that are likely to                SUMMARY:   Notice is hereby given that on               PNAS 107:6551, 2010 April 6
                                                lead to products being considered                       April 2, 2018, the Department of Health               • Biochem. 44:10757–10765, 2005 (hereafter
                                                adulterated. A dietary supplement is                    and Human Services (HHS) Debarring                      referred to as ‘‘Biochem. 2005’’)
                                                adulterated under section 402(f)(1)(A) of               Official, on behalf of the Secretary of               • Proc. Natl. Acad. Sci. USA 103:2126–2131,
                                                                                                        HHS, issued a final notice of debarment                 2006 (hereafter referred to as ‘‘PNAS
                                                the FD&C Act (21 U.S.C. 342(f)(1)(A)) if
                                                                                                        based on the findings of research                       2006’’); Editorial Expression of Concern in:
                                                it presents a significant or unreasonable                                                                       PNAS 107:6551, 2010 April 6
                                                risk of illness or injury under the                     misconduct made by the Office of
                                                                                                        Research Integrity (ORI) against H.M.                 • Acta Cryst. D55:1971–1977, 1999 (hereafter
                                                conditions of use recommended or                                                                                referred to as ‘‘Acta Cryst. 1999’’); retracted
                                                suggested in the labeling or, if no                     Krishna Murthy, Ph.D., former Research                  in: Acta Cryst. D66:222, 2010
                                                conditions for use are suggested or                     Associate Professor, Department of                    • J. Mol. Biol. 301:759–767, 2000 (hereafter
                                                recommended, under ordinary                             Vision Sciences, University of Alabama                  referred to as ‘‘J. Mol. Biol. 2000’’);
                                                conditions of use. In recent years, we                  at Birmingham (UAB).                                    retracted in: J. Mol. Biol. 397:1119, 2010
                                                have seen the emergence of powdered                        Dr. Murthy engaged in research                     • Cell 104:301–311, 2001 (hereafter referred
                                                                                                        misconduct in research supported by                     to as ‘‘Cell 2001’’)
                                                and liquid dietary supplement products
                                                                                                        U.S. Public Health Service (PHS) grants,              • Biochem. 41:11681–11691, 2002 (hereafter
                                                containing high concentrations of                                                                               referred to as ‘‘Biochem. 2002’’)
                                                caffeine marketed directly to consumers.                specifically National Institute of Allergy
                                                                                                                                                              • Protein Data Bank (PDB) identification
                                                These products are often sold in bulk                   and Infectious Diseases (NIAID),
                                                                                                                                                                codes 2HR0, 1BEF, 1RID, 1Y8E, 2A01,
                                                containers with hundreds or thousands                   National Institutes of Health (NIH),                    1CMW, 2QID, 1DF9, 1G40, 1G44, 2OU1,
                                                of servings in the container, and even a                grants R01 AI051615, R01 AI032078,                      and 1L6L (the PDB is funded in part by
                                                small dose can be toxic or deadly. The                  and R01 AI045623; National Heart,                       NIH)
                                                consumer is required to measure out a                   Lung, and Blood Institute (NHLBI), NIH,                 Falsified and/or fabricated research results
                                                small, precise serving from what is often               grants P01 HL034343 and R01                           also were referenced in the following PHS
                                                a potentially lethal amount of product.                 HL064272; and National Institute of                   grant applications:
                                                These products pose a significant or                    Diabetes and Digestive and Kidney                     • 1 R21 AI056224–01 submitted to NIAID,
                                                unreasonable risk of illness or injury.                 Diseases (NIDDK), NIH, grant R01                        NIH
srobinson on DSK3G9T082PROD with NOTICES




                                                   When formulated appropriately,                       DK046900. The administrative actions,                 • 1 R01 AI064509–01 submitted to NIAID,
                                                caffeine can be an ingredient in a                      including ten (10) years of debarment,                  NIH
                                                                                                        were implemented beginning on April                   • 1 R01 AI64509–01A1 submitted to NIAID,
                                                dietary supplement that does not                                                                                NIH
                                                present a significant or unreasonable                   2, 2018, and are detailed below.
                                                                                                                                                              • 1 R01 AI051615–01A1 submitted to NIAID,
                                                risk of illness or injury. The guidance                 FOR FURTHER INFORMATION CONTACT:                        NIH
                                                provides suggestions on how                             Wanda K. Jones, Dr.P.H., Interim                      • 1 R03 TW006840–01 submitted to Fogarty
                                                manufacturers can formulate safer                       Director, Office of Research Integrity,                 International Center (FIC), NIH



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                                                                               Federal Register / Vol. 83, No. 73 / Monday, April 16, 2018 / Notices                                                  16371

                                                   ORI found by a preponderance of the                     Biochem. 2002 and the corresponding                  (3) ORI will send a notice to the
                                                evidence that Respondent intentionally,                    coordinate file deposited in the PDB               pertinent journals of the following
                                                knowingly, or recklessly engaged in                        for entry 2OU1                                     publications that require retraction or
                                                research misconduct by falsifying and/                  • the protein crystal structure of                    correction and to the PDB for the
                                                or fabricating X-ray crystallographic                      apolipoprotein A–II in complex with                following entries that require
                                                data for eleven (11) protein structures                    b-octyl glucoside reported in                      obsolescence, in accordance with 42
                                                and falsely reporting them as                              Biochem. 2002 and the corresponding                CFR 93.407(a)(1) and 93.411(b):
                                                experimentally derived from X-ray                          coordinate file deposited in the PDB               —Cell 104:301–311, 2001
                                                diffraction experiments in nine (9)                        for entry IL6L                                     —Biochem. 41:11681–11691, 2002
                                                publications and in twelve (12) deposits                • the protein crystal structure of dengue             —Proc. Natl. Acad. Sci. USA 101:8924–
                                                in the PDB. ORI found that Respondent                      virus NS3 protease in complex with a                 8929, 2004
                                                intentionally, knowingly, or recklessly                    Bowman-Birk inhibitor reported in J.               —Biochem. 44:10757–10765, 2005
                                                falsified and/or fabricated the PDB                        Mol. Biol. 2000 and the corresponding              —Proc. Natl. Acad. Sci. USA 103:2126–
                                                coordinate files deposited for all of the                  coordinate files deposited in the PDB                2131, 2006
                                                eleven (11) structures (PDB entries                        for entries 2QID and 1DF9                          —PDB entries 1RID, 1Y8E, 2A01, 1G40,
                                                2HR0, 1BEF, 1RID, 1Y8E, 2A01, 1CMW,                        ORI issued a charge letter                           1G44, 2OU1, and 1L6L
                                                1G40, 1G44, 2OU1, 1L6L, 2QID, and                       enumerating the above findings of                     Wanda K. Jones,
                                                1DF9) and the X-ray diffraction data                    research misconduct and proposing                     Interim Director, Office of Research Integrity.
                                                (structure factors) corresponding to six                HHS administrative actions. Respondent
                                                                                                                                                              [FR Doc. 2018–07782 Filed 4–13–18; 8:45 am]
                                                (6) of the eleven (11) structures (PDB                  subsequently requested a hearing before
                                                                                                                                                              BILLING CODE 4150–31–P
                                                entries 2HR0, 1BEF, 1RID, 1Y8E, 2A01,                   an Administrative Law Judge (ALJ) of
                                                and 1CMW).                                              the Departmental Appeals Board to
                                                   Specifically, Respondent falsified                   dispute these findings. ORI filed a
                                                                                                                                                              DEPARTMENT OF HEALTH AND
                                                and/or fabricated:                                      motion for summary judgment, which
                                                                                                                                                              HUMAN SERVICES
                                                • The protein crystal structure of                      Respondent opposed. On January 19,
                                                   complement component C3b reported                    2018, the ALJ issued a recommended                    Indian Health Service
                                                   in Nature 2006 and the corresponding                 decision to the Acting Assistant
                                                   structure factors and coordinate file                Secretary for Health (ASH) granting                   Indian Health Professions Preparatory,
                                                   deposited in the PDB for entry 2HR0                  summary judgment in favor of ORI and                  Indian Health Professions Pre-
                                                • the protein crystal structure of dengue               sustaining ORI’s proposal to impose a                 Graduate and Indian; Health
                                                   virus NS3 serine protease reported in                ten-year debarment and a ten-year ban                 Professions Scholarship Programs
                                                   J. Biol. Chem. 1999 and the                          on PHS advisory services against
                                                   corresponding structure factors and                  Respondent as well as correction of                   Announcement Type: Initial
                                                                                                                                                              CFDA Numbers: 93.971, 93.123, and 93.972
                                                   coordinate file deposited in the PDB                 Respondent’s research record. The
                                                   for entry 1BEF                                       Acting ASH served a copy of the ALJ’s                 Key Dates
                                                • the protein crystal structure of                      recommended decision on the HHS                       Application Deadline Date: April 13,
                                                   vaccinia virus complement control                    Debarring Official pursuant to 42 CFR                   2018, 7:00 p.m. Eastern for continuing
                                                   protein (VCP) in complex with                        93.523(c), and the decision constituted                 students
                                                   heparin reported in PNAS 2004 and                    the findings of fact to the HHS                       Application Deadline Date: April 13,
                                                   the corresponding structure factors                  Debarring Official in accordance with 2                 2018, 7:00 p.m. Eastern for new
                                                   and coordinate file deposited in the                 CFR 180.845(c). On April 2, 2018, the                   students
                                                   PDB for entry 1RID                                   HHS Debarring Official issued a final                 Application Review Date: May 7–25,
                                                • the protein crystal structure of VCP in               notice of debarment to begin on April 2,                2018
                                                   complex with suramin (VCP-suramin)                   2018, and end on April 1, 2028. Thus,                 Continuation Award Notification
                                                   reported in Biochem. 2005 and the                    the research misconduct findings set                    Deadline Date: June 5, 2018
                                                   corresponding structure factors and                  forth above became effective, and the                 New Award Notification Deadline Date:
                                                   coordinate file deposited in the PDB                 following administrative actions have                   July 15, 2018
                                                   for entry 1Y8E                                       been implemented, beginning on April                  Award Start Date: August 1, 2018
                                                • the protein crystal structure of                      2, 2018:                                              Acceptance/Decline of Awards Deadline
                                                   apolipoprotein A–I reported in PNAS                     (1) Dr. Murthy is debarred for a period              Date: August 15, 2018
                                                   2006 and the corresponding structure                 of ten (10) years from eligibility for any
                                                                                                        contracting or subcontracting with any                I. Funding Opportunity Description
                                                   factors and coordinate file deposited
                                                   in the PDB for entry 2A01                            agency of the United States Government                   The Indian Health Service (IHS) is
                                                • the protein crystal structure of Taq                  and from eligibility for or involvement               committed to encouraging American
                                                   DNA polymerase reported in Acta                      in nonprocurement programs of the                     Indians and Alaska Natives to enter the
                                                   Cryst. 1999 and the corresponding                    United States Government, referred to as              health professions and to assuring the
                                                   structure factors and coordinate file                ‘‘covered transactions,’’ pursuant to                 availability of Indian health
                                                   deposited in the PDB for entry 1CMW                  HHS’ Implementation (2 CFR part 376)                  professionals to serve Indians. The IHS
                                                • the protein crystal structure of VCP                  of Office of Management and Budget                    is committed to the recruitment of
                                                   crystal form I reported in Cell 2001                 (OMB) Guidelines to Agencies on                       students for the following programs:
                                                   and the corresponding coordinate                     Governmentwide Debarment and                             • The Indian Health Professions
                                                   files deposited in the PDB for entry                 Suspension (2 CFR part 180);                          Preparatory Scholarship (Preparatory
srobinson on DSK3G9T082PROD with NOTICES




                                                   1G40                                                    (2) Dr. Murthy is prohibited from                  Scholarship) authorized by Section 103
                                                • the protein crystal structure of VCP                  serving in any advisory capacity to PHS               of the Indian Health Care Improvement
                                                   crystal form II reported in Cell 2001                including, but not limited to, service on             Act, Public Law 94–437 (1976), as
                                                   and the corresponding coordinate file                any PHS advisory committee, board,                    amended (IHCIA), codified at 25 U.S.C.
                                                   deposited in the PDB for entry 1G44                  and/or peer review committee, or as a                 1613(b)(1).
                                                • the protein crystal structure of                      consultant for a period of ten (10) years;               • The Indian Health Professions Pre-
                                                   apolipoprotein A–II reported in                      and                                                   graduate Scholarship (Pre-graduate


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Document Created: 2018-04-14 02:19:16
Document Modified: 2018-04-14 02:19:16
CategoryRegulatory Information
CollectionFederal Register
sudoc ClassAE 2.7:
GS 4.107:
AE 2.106:
PublisherOffice of the Federal Register, National Archives and Records Administration
SectionNotices
ActionNotice.
ContactWanda K. Jones, Dr.P.H., Interim Director, Office of Research Integrity, 1101 Wootton Parkway, Suite 750, Rockville, MD 20852, (240) 453-8200.
FR Citation83 FR 16370 

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