83 FR 823 - Interagency Coordinating Committee on the Validation of Alternative Methods Communities of Practice Webinar on Machine Learning in Toxicology: Fundamentals of Application and Interpretation; Notice of Public Webinar; Registration Information
DEPARTMENT OF HEALTH AND HUMAN SERVICES
National Institutes of Health Federal Register Volume 83, Issue 5 (January 8, 2018)
National Institutes of Health
Federal Register Volume 83, Issue 5 (January 8, 2018)
| Page Range | 823-824 | |
| FR Document | 2018-00120 |
[Federal Register Volume 83, Number 5 (Monday, January 8, 2018)] [Notices] [Pages 823-824] From the Federal Register Online [www.thefederalregister.org] [FR Doc No: 2018-00120] ----------------------------------------------------------------------- DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Interagency Coordinating Committee on the Validation of Alternative Methods Communities of Practice Webinar on Machine Learning in Toxicology: Fundamentals of Application and Interpretation; Notice of Public Webinar; Registration Information AGENCY: National Institutes of Health, HHS. ACTION: Notice. ----------------------------------------------------------------------- SUMMARY: The Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) announces a public webinar ``Machine Learning in Toxicology: Fundamentals of Application and Interpretation.'' The webinar is organized on behalf of ICCVAM by the National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM). Interested persons may participate via WebEx. Time will be allotted for questions from the audience. DATES: Webinar: January 23, 2018, 1:00 p.m. to approximately 2:30 p.m. Eastern Standard Time (EST). Registration for the Webinar: December 18, 2017, until 2:30 p.m. on January 23, 2018. ADDRESSES: Webinar web page: http://ntp.niehs.nih.gov/go/commprac-2018. FOR FURTHER INFORMATION CONTACT: Dr. Warren Casey, Director, NICEATM; telephone: (984) 287-3118; email: warren.casey@nih.gov. SUPPLEMENTARY INFORMATION: Background: ICCVAM promotes the development and validation of toxicity testing methods that protect human health and the environment while replacing, reducing, or refining animal use. ICCVAM also provides guidance to test method developers and facilitates collaborations that promote the development of new test methods. To address these goals, ICCVAM will hold a Communities of Practice webinar on ``Machine Learning in Toxicology: Fundamentals of Application and Interpretation.'' The ICCVAM webinar will explore the fundamentals of machine learning approaches, including how they work, how they are interpreted, and precautions that should be taken when evaluating their output. It will feature presentations by two experts in use of machine learning in toxicity texting applications that will address issues specific to use of machine learning approaches in a regulatory context. Case studies will be presented to highlight where such techniques have been successfully applied both nationally and internationally. The preliminary agenda and additional information about presentations will be posted at http://ntp.niehs.nih.gov/go/commprac-2018 as available. Webinar and Registration: This webinar is open to the public with time scheduled for questions by participants following each presentation. Registration for the webinar is required and is open through 2:30 p.m. on January 23, 2018. Registration is available at http://ntp.niehs.nih.gov/go/commprac-2018. Interested individuals are encouraged to visit this web page to stay abreast of the most current webinar information. Registrants will receive instructions on how to access and participate in the webinar in an email sent shortly before the webinar. Individuals with disabilities who need accommodation to participate in this event should contact Elizabeth Maull at phone: (984) 287-3157 or email: maull@niehs.nih.gov. TTY users should contact the Federal TTY Relay Service at (800) 877-8339. Requests should be made at least five business days in advance of the event. Background Information on ICCVAM and NICEATM: ICCVAM is an interagency committee composed of representatives from 16 federal regulatory and research agencies that require, use, generate, or disseminate toxicological and safety testing information. ICCVAM conducts technical evaluations of new, revised, and alternative safety testing methods and integrated testing strategies with regulatory applicability and promotes the scientific validation and regulatory acceptance of testing methods that more accurately assess the safety and hazards of chemicals and products and replace, reduce, or refine (enhance animal well-being and lessen or avoid pain and distress) animal use. The ICCVAM Authorization Act of 2000 (42 U.S.C. 285l-3) establishes ICCVAM as a permanent interagency committee of the National Institute of Environmental Health Sciences and provides the authority for ICCVAM involvement in activities relevant to the development of alternative test methods. ICCVAM acts to ensure that new and revised test methods are validated to meet the needs of federal agencies, increase the efficiency and effectiveness of federal agency test method review, and optimize utilization of scientific expertise outside the federal government. Additional information [[Page 824]] about ICCVAM can be found at http://ntp.niehs.nih.gov/go/iccvam. NICEATM administers ICCVAM, provides scientific and operational support for ICCVAM-related activities, and conducts and publishes analyses and evaluations of data from new, revised, and alternative testing approaches. NICEATM and ICCVAM work collaboratively to evaluate new and improved testing approaches applicable to the needs of U.S. federal agencies. NICEATM and ICCVAM welcome the public nomination of new, revised, and alternative test methods and strategies for validation studies and technical evaluations. Additional information about NICEATM can be found at http://ntp.niehs.nih.gov/go/niceatm. Dated: December 20, 2017. John R. Bucher, Associate Director, National Toxicology Program. [FR Doc. 2018-00120 Filed 1-5-18; 8:45 am] BILLING CODE 4140-01-P
![Federal Register / Vol. 83, No. 5 / Monday, January 8, 2018 / Notices 823
have proven to be both highly antigenic DEPARTMENT OF HEALTH AND approaches in a regulatory context. Case
and shown to be responsible in allowing HUMAN SERVICES studies will be presented to highlight
malaria parasites to evade the mosquito where such techniques have been
immune system. Proof of concept in a National Institutes of Health successfully applied both nationally and
mouse model has demonstrated that internationally. The preliminary agenda
vaccination using specific P47 protein Interagency Coordinating Committee and additional information about
fragments blocks Plasmodium on the Validation of Alternative presentations will be posted at http://
transmission by mosquitoes. Methods Communities of Practice ntp.niehs.nih.gov/go/commprac-2018 as
Webinar on Machine Learning in available.
Immunization with the P47 protein Toxicology: Fundamentals of
variants of this technology provides a Webinar and Registration: This
Application and Interpretation; Notice webinar is open to the public with time
candidate for a potential, effective, of Public Webinar; Registration
transmission blocking malaria vaccine scheduled for questions by participants
Information following each presentation.
against Plasmodium species.
AGENCY: National Institutes of Health, Registration for the webinar is required
This technology is available for
HHS. and is open through 2:30 p.m. on
licensing for commercial development
ACTION: Notice. January 23, 2018. Registration is
in accordance with 35 U.S.C. 209 and 37
available at http://ntp.niehs.nih.gov/go/
CFR part 404, as well as for further
SUMMARY: The Interagency Coordinating commprac-2018. Interested individuals
development and evaluation under a
Committee on the Validation of are encouraged to visit this web page to
research collaboration.
Alternative Methods (ICCVAM) stay abreast of the most current webinar
Potential Commercial Applications: announces a public webinar ‘‘Machine information. Registrants will receive
• Transmission blocking malaria Learning in Toxicology: Fundamentals instructions on how to access and
vaccine of Application and Interpretation.’’ The participate in the webinar in an email
webinar is organized on behalf of sent shortly before the webinar.
Competitive Advantages: ICCVAM by the National Toxicology Individuals with disabilities who
• Transmission blocking of Program Interagency Center for the need accommodation to participate in
Plasmodium Evaluation of Alternative Toxicological this event should contact Elizabeth
Methods (NICEATM). Interested persons Maull at phone: (984) 287–3157 or
• Transmission blocking activity based
may participate via WebEx. Time will email: maull@niehs.nih.gov. TTY users
on recruiting the mosquito immune
be allotted for questions from the should contact the Federal TTY Relay
system to kill Plasmodium parasites
audience. Service at (800) 877–8339. Requests
by blocking Plasmodium immune
should be made at least five business
evasion DATES: Webinar: January 23, 2018, 1:00
days in advance of the event.
p.m. to approximately 2:30 p.m. Eastern
Development Stage: Background Information on ICCVAM
Standard Time (EST). Registration for
and NICEATM: ICCVAM is an
• Early-stage the Webinar: December 18, 2017, until
interagency committee composed of
• In vitro data available 2:30 p.m. on January 23, 2018.
representatives from 16 federal
ADDRESSES: Webinar web page: http://
• In vivo data available (animal) regulatory and research agencies that
ntp.niehs.nih.gov/go/commprac-2018. require, use, generate, or disseminate
Inventors: Carolina Veronica Barillas- FOR FURTHER INFORMATION CONTACT: Dr. toxicological and safety testing
Mury, Alvaro Molina-Cruz, Gaspar Warren Casey, Director, NICEATM; information. ICCVAM conducts
Exequiel Canepa, all of NIAID. telephone: (984) 287–3118; email: technical evaluations of new, revised,
Publications: warren.casey@nih.gov. and alternative safety testing methods
Intellectual Property: HHS Reference SUPPLEMENTARY INFORMATION: and integrated testing strategies with
No. E–294–2016/0—U.S. Provisional Background: ICCVAM promotes the regulatory applicability and promotes
Application No. 62/463,011, filed development and validation of toxicity the scientific validation and regulatory
February 24, 2017. testing methods that protect human acceptance of testing methods that more
Licensing Contact: Peter Tung, 240– health and the environment while accurately assess the safety and hazards
669–5483; peter.tung@nih.gov. replacing, reducing, or refining animal of chemicals and products and replace,
use. ICCVAM also provides guidance to reduce, or refine (enhance animal well-
Collaborative Research Opportunity: being and lessen or avoid pain and
test method developers and facilitates
The National Institute of Allergy and distress) animal use.
collaborations that promote the
Infectious Diseases is seeking statements
development of new test methods. To The ICCVAM Authorization Act of
of capability or interest from parties
address these goals, ICCVAM will hold 2000 (42 U.S.C. 285l–3) establishes
interested in collaborative research to
a Communities of Practice webinar on ICCVAM as a permanent interagency
further develop, evaluate or
‘‘Machine Learning in Toxicology: committee of the National Institute of
commercialize P47 protein fragments as
Fundamentals of Application and Environmental Health Sciences and
a transmission blocking vaccine. For
Interpretation.’’ provides the authority for ICCVAM
collaboration opportunities, please
The ICCVAM webinar will explore involvement in activities relevant to the
contact Peter Tung at 240–669–5483;
the fundamentals of machine learning development of alternative test
peter.tung@nih.gov.
approaches, including how they work, methods. ICCVAM acts to ensure that
sradovich on DSK3GMQ082PROD with NOTICES
Dated: December 13, 2017. how they are interpreted, and new and revised test methods are
Suzanne Frisbie, precautions that should be taken when validated to meet the needs of federal
Deputy Director, Technology Transfer and evaluating their output. It will feature agencies, increase the efficiency and
Intellectual Property Office, National Institute presentations by two experts in use of effectiveness of federal agency test
of Allergy and Infectious Diseases. machine learning in toxicity texting method review, and optimize utilization
[FR Doc. 2018–00121 Filed 1–5–18; 8:45 am] applications that will address issues of scientific expertise outside the federal
BILLING CODE 4140–01–P specific to use of machine learning government. Additional information
VerDate Sep<11>2014 16:29 Jan 05, 2018 Jkt 244001 PO 00000 Frm 00041 Fmt 4703 Sfmt 4703 E:\FR\FM\08JAN1.SGM 08JAN1](https://thefederalregister.org/doc/83_FR_828/page/1.svg)
![824 Federal Register / Vol. 83, No. 5 / Monday, January 8, 2018 / Notices
about ICCVAM can be found at http:// (1) Email. Submit comments to: CBP_ Overview of This Information
ntp.niehs.nih.gov/go/iccvam. PRA@cbp.dhs.gov. Collection
NICEATM administers ICCVAM, (2) Mail. Submit written comments to Title: Application for Allowance in
provides scientific and operational CBP Paperwork Reduction Act Officer, Duties.
support for ICCVAM-related activities, U.S. Customs and Border Protection, OMB Number: 1651–0007.
and conducts and publishes analyses Form Number: CBP Form 4315.
Office of Trade, Regulations and
and evaluations of data from new, Action: CBP proposes to extend the
Rulings, Economic Impact Analysis
revised, and alternative testing expiration date of this information
approaches. NICEATM and ICCVAM Branch, 90 K Street NE, 10th Floor,
Washington, DC 20229–1177. collection with no change to the burden
work collaboratively to evaluate new hours or to Form 4315.
and improved testing approaches FOR FURTHER INFORMATION CONTACT: Type of Review: Extension (without
applicable to the needs of U.S. federal Requests for additional PRA information change).
agencies. NICEATM and ICCVAM should be directed to Seth Renkema, Abstract: CBP Form 4315,
welcome the public nomination of new, Chief, Economic Impact Analysis ‘‘Application for Allowance in Duties,’’
revised, and alternative test methods Branch, U.S. Customs and Border is submitted to CBP in instances of
and strategies for validation studies and Protection, Office of Trade, Regulations claims of damaged or defective
technical evaluations. Additional and Rulings, 90 K Street NE, 10th Floor, imported merchandise on which an
information about NICEATM can be Washington, DC 20229–1177, allowance in duty is made in the
found at http://ntp.niehs.nih.gov/go/ Telephone number (202) 325–0056 or liquidation of the entry. The
niceatm. information on this form is used to
via email CBP_PRA@cbp.dhs.gov. Please
Dated: December 20, 2017. note that the contact information substantiate an importer’s claim for
John R. Bucher, provided here is solely for questions such duty allowances. CBP Form 4315
Associate Director, National Toxicology regarding this notice. Individuals is authorized by 19 U.S.C. 1506 and
Program. seeking information about other CBP provided for by 19 CFR 158.11, 158.13
[FR Doc. 2018–00120 Filed 1–5–18; 8:45 am] programs should contact the CBP and 158.23. This form is accessible at:
BILLING CODE 4140–01–P National Customer Service Center at http://www.cbp.gov/sites/default/files/
documents/CBP%20Form%204315_
877–227–5511, (TTY) 1–800–877–8339,
0.pdf.
or CBP website at https://
Affected Public: Businesses.
DEPARTMENT OF HOMELAND www.cbp.gov/. Estimated Number of Respondents:
SECURITY SUPPLEMENTARY INFORMATION: CBP 12,000.
invites the general public and other Estimated Number of Total Annual
U.S. Customs and Border Protection Responses: 12,000.
Federal agencies to comment on the
[1651–0007] proposed and/or continuing information Estimated Time per Response: 8
collections pursuant to the Paperwork minutes.
Agency Information Collection Reduction Act of 1995 (44 U.S.C. 3501 Estimated Annual Burden Hours:
Activities: Application for Allowance in et seq.). This process is conducted in 1,600.
Duties accordance with 5 CFR 1320.8. Written Dated: January 2, 2018.
AGENCY: U.S. Customs and Border comments and suggestions from the Seth Renkema,
Protection (CBP), Department of public and affected agencies should Branch Chief, Economic Impact Analysis
address one or more of the following Branch, U.S. Customs and Border Protection.
Homeland Security.
four points: (1) Whether the proposed [FR Doc. 2018–00071 Filed 1–5–18; 8:45 am]
ACTION: 60-Day notice and request for
comments; extension of an existing collection of information is necessary BILLING CODE 9111–14–P
collection of information. for the proper performance of the
functions of the agency, including
SUMMARY: The Department of Homeland whether the information will have DEPARTMENT OF HOMELAND
Security, U.S. Customs and Border practical utility; (2) the accuracy of the SECURITY
Protection will be submitting the agency’s estimate of the burden of the U.S. Customs and Border Protection
following information collection request proposed collection of information,
to the Office of Management and Budget including the validity of the [1651–0127]
(OMB) for review and approval in methodology and assumptions used; (3)
accordance with the Paperwork Agency Information Collection
suggestions to enhance the quality,
Reduction Act of 1995 (PRA). The Activities: Guarantee of Payment
utility, and clarity of the information to
information collection is published in be collected; and (4) suggestions to AGENCY: U.S. Customs and Border
the Federal Register to obtain comments minimize the burden of the collection of Protection (CBP), Department of
from the public and affected agencies. information on those who are to Homeland Security.
Comments are encouraged and will be respond, including through the use of ACTION: 60-Day notice and request for
accepted (no later than March 9, 2018)
appropriate automated, electronic, comments; extension of an existing
to be assured of consideration.
mechanical, or other technological collection of information.
ADDRESSES: Written comments and/or
sradovich on DSK3GMQ082PROD with NOTICES
collection techniques or other forms of
suggestions regarding the item(s) information technology, e.g., permitting SUMMARY: The Department of Homeland
contained in this notice must include electronic submission of responses. The Security, U.S. Customs and Border
the OMB Control Number 1651–0007 in Protection will be submitting the
comments that are submitted will be
the subject line and the agency name. following information collection request
summarized and included in the request
To avoid duplicate submissions, please to the Office of Management and Budget
for approval. All comments will become
use only one of the following methods (OMB) for review and approval in
to submit comments: a matter of public record. accordance with the Paperwork
VerDate Sep<11>2014 16:29 Jan 05, 2018 Jkt 244001 PO 00000 Frm 00042 Fmt 4703 Sfmt 4703 E:\FR\FM\08JAN1.SGM 08JAN1](https://thefederalregister.org/doc/83_FR_828/page/2.svg)
Document Created: 2018-01-06 02:32:02
Document Modified: 2018-01-06 02:32:02
| Category | Regulatory Information | |
| Collection | Federal Register | |
| sudoc Class | AE 2.7: GS 4.107: AE 2.106: | |
| Publisher | Office of the Federal Register, National Archives and Records Administration | |
| Section | Notices | |
| Action | Notice. | |
| Dates | Webinar: January 23, 2018, 1:00 p.m. to approximately 2:30 p.m. Eastern Standard Time (EST). Registration for the Webinar: December 18, 2017, until 2:30 p.m. on January 23, 2018. | |
| Contact | Dr. Warren Casey, Director, NICEATM; telephone: (984) 287-3118; email: [email protected] | |
| FR Citation | 83 FR 823 |
2024 Federal Register | Disclaimer | Privacy Policy
USC | CFR | eCFR